Convergent Fabrication of Allicin Loaded Polymeric Nanoparticles for Treatment of In Vitro Squamous Carcinoma Cells and Systemic Toxicity

Fan, Zhixia; Zhang, Jing; Wang, Xin; Miao, Guoying

doi:10.1007/s10876-022-02246-1

Cited by 1 publication

(1 citation statement)

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“…Nanoparticles are nanoscale materials (1–100 nm) with a high surface area and reactivity that can be employed for food delivery to enhance the bioavailability, functionality, quality, and safety of food products by offering high loading capacity and stability, sustained controlled-release properties, and the ability to transport hydrophilic and lipophilic nutrients across cell membranes and biological barriers. , Fan et al prepared allicin-loaded polylactic acid–glycolic acid nanoparticles by a water–oil–water emulsion method with high encapsulation efficiency (EE) and drug loading, as well as a steady controlled-release rate of 75.0 ± 79.20% in an acidic environment and 14.0 ± 67.44% in a neutral environment . Ossama et al prepared allicin-loaded gelatin nanoparticles with poloxamer 188 coating by a double-desolvation method with a particle size of 714 ± 25.21 nm, a PDI of 0.663 ± 0.143, and an EE of 39.32% ± 1.3 .…”

Section: Delivery Systemsmentioning

confidence: 99%

Bioavailability, Health Benefits, and Delivery Systems of Allicin: A Review

Deng,

Ho,

Lan

et al. 2023

J. Agric. Food Chem.

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Garlic has been used worldwide as a spice due to its pungent taste and flavor-enhancing properties. As a main biologically active component of the freshly crushed garlic extracts, allicin (diallyl thiosulfinate) is converted from alliin by alliinase upon damaging the garlic clove, which has been reported to have many potent beneficial biological functions. In this work, allicin formation, stability, bioavailability, and metabolism process are examined and summarized. The biological functions of allicin and potential underlying mechanisms are reviewed and discussed, including antioxidation, anti-inflammation, antidiabetic, cardioprotective, antineurodegenerative, antitumor, and antiobesity effects. Novel delivery systems of allicin with enhanced stability, encapsulation efficiency, and bioavailability are also evaluated, such as nanoparticles, gels, liposomes, and micelles. This study could provide a comprehensive understanding of the physiochemical properties and health benefits of allicin, with great potential for further applications in the food and nutraceutical industries.

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