Convergence of visceral and somatic inputs onto subnucleus reticularis dorsalis neurones in the rat medulla.

Roy, J.C.; Zhu, Bing; Villanueva, Luis; Bars, D. Le

doi:10.1113/jphysiol.1992.sp019415

Cited by 40 publications

(23 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many neurons in the dorsal caudal medulla receive inputs from the spinal cord (Lima, 1990;Villanueva et al, 1991;Raboisson et al, 1996;Wang et al, 1999) and respond to noxious stimuli from wide areas of the body (Villanueva et al, 1988(Villanueva et al, , 1989Roy et al, 1992;Tsuruoka et al, 1997;Almeida et al, 1999). Similarly, the NTS receives inputs from neurons in the spinal cord (Menetrey and Basbaum, 1987;Mtui et al, 1993Mtui et al, , 1995Mifflin, 1994, 2000;Wang et al, 1999;Gamboa-Esteves et al, 2001), projects back to it via the solitariospinal tract (Loewy and Burton, 1978;Mtui et al, 1993Mtui et al, , 1995, and has been implicated in the processing of painful stimuli (Lewis et al, 1987;Aicher and Randich, 1990;Traub et al, 1996).…”

Section: Subnucleus Reticularis Dorsalis and Nucleus Tractus Solitariusmentioning

confidence: 97%

Defining projections from the caudal pressor area of the caudal ventrolateral medulla

Sun

Panneton

2004

J. Comp. Neurol.

View full text Add to dashboard Cite

We previously defined a functional area in the caudal medulla oblongata that elicits an increase in arterial pressure when stimulated (Sun and Panneton [2002] Am. J. Physiol. 283:R768-R778). In the present study, anterograde and retrograde tracing techniques were used to investigate the projections of this caudal pressor area (CPA) to the medulla and pons. Injections of biotinylated dextran amine into the CPA resulted in numerous labeled fibers with varicosities in the ipsilateral subnucleus reticularis dorsalis, commissural subnucleus of the nucleus tractus solitarii, lateral medulla, medial facial nucleus, A5 area, lateral vestibular nucleus, and internal lateral subnucleus of the parabrachial complex. Sparser projections were found ipsilaterally in the pressor and depressor areas of the medulla and the spinal trigeminal nucleus and contralaterally in the CPA. Injections of the retrograde tracer Fluoro-Gold into these areas labeled neurons in the CPA as well as the nearby medullary dorsal horn and reticular formation. However, we conclude that the CPA projects preferentially to the subnucleus reticularis dorsalis, commissural nucleus tractus solitarii, lateral medulla, A5 area, and internal lateral parabrachial nucleus. Weaker projections were seen to the CVLM and RVLM and to the contralateral CPA. The projection to the facial nucleus arises from nearby reticular neurons, whereas projections to the vestibular nucleus arise from the lateral reticular nucleus. Labeled neurons in the CPA consisted mostly of small bipolar and some triangular neurons. The projection to the CVLM, or to A5 area, may provide for the increase in arterial pressure with CPA stimulation. However, most of the projections described herein are to nuclei implicated in the processing of noxious information. This implies a unique role for the CPA in somatoautonomic regulation.

show abstract

Section: Subnucleus Reticularis Dorsalis and Nucleus Tractus Solitariusmentioning

confidence: 97%

Defining projections from the caudal pressor area of the caudal ventrolateral medulla

Sun

Panneton

2004

J. Comp. Neurol.

View full text Add to dashboard Cite

show abstract

“…Ammons et al (1985) showed that viscerocutaneous spinothalamic tract neurons project to the medial thalamus including the parafascicular and centrolateral nuclei and these nuclei receive input from the pronociceptive subnucleus reticularis dorsalis (Villanueva et al, 1998) as does the parabrachial nucleus (Bester et al, 1999). Both of these latter nuclei respond to visceral and cutaneous nociceptive stimulation (Roy et al, 1992;Villanueva et al, 1989). Thus, non-somatotopic, viscerocutaneous nociception in ACC derives from spinal cord, subnucleus reticularis dorsalis and parabrachial nuclei via the MITN.…”

Section: Source and Latency Of Visceral Nociceptive Signalmentioning

confidence: 99%

Distribution and properties of visceral nociceptive neurons in rabbit cingulate cortex

Sikes

Vogt

2008

Pain

View full text Add to dashboard Cite

Human imaging localizes most visceral nociceptive responses to anterior cingulate cortex (ACC), however, imaging in conscious subjects cannot completely control anticipatory and reflexive activity or resolve neuron activity. This study overcame these shortcomings by recording individual neuron responses in 12 anesthetized and paralyzed rabbits to define the visceronociceptive response pattern by region and layer. Balloon distension was applied to the colon at innocuous (15 mmHg) or noxious (60 mmHg) intensities, and innocuous and noxious mechanical, thermal and electrical stimuli were applied to the skin. Simultaneous recording from multiple regions assured differences were not due to anesthesia and neuron responses were resolved by spike sorting using principal components analysis. Of the total 346 neurons, 48% were nociceptive; responding to noxious levels of visceral or cutaneous stimulation, or both. Visceronociceptive neurons were most frequent in ACC (39%) and midcingulate cortex (MCC, 36%) and infrequent in retrosplenial cortex (RSC, 12%). In contrast, cutaneous nociceptive units were higher in MCC (MCC, 43%; ACC, 32%; RSC, 23%). Visceralspecific neurons were proportionately more frequent in ACC (37%), while cutaneous-specific units predominated in RSC (62.5%). Visceral nociceptive response durations were longer than those for cutaneous responses. Postmortem analysis of electrode tracks confirmed regional designations, and laminar analysis found inhibitory responses mainly in superficial layers and excitatory in deep layers. Thus, cingulate visceral nociception extends beyond ACC, this is the first report of nociceptive activity in RSC including nociceptive cutaneous responses, and these regional differences require a new model of cingulate nociceptive processing.

show abstract

“…In this new context, it could be interesting to investigate whether noxious visceral inputs conveyed in the lemniscal system to the forebrain arise only from the dorsal column nuclei or from two neighbouring, parallel systems in the dorsal-most aspect of the caudal medulla, viz. the Cu and SRD, since SRD units are also driven by visceral noxious inputs (Roy et al, 1992).…”

Section: Projections From the Cu To The Diencephalon: Functional Consmentioning

confidence: 99%

“…By comparison with other brainstem reticular neurons (for reviews, see Bowsher, 1976;Gebhart, 1982;Villanueva et al, 1996), this population does not respond to visual, auditory or proprioceptive stimuli and encodes the intensity of noxious thermal, mechanical, and visceral stimuli Roy et al, 1992). The A␦-and C-fiber evoked activities of these neurons are depressed by morphine in a dose-related and naloxone-reversible fashion and the spinal pathways responsible for their activation ascend in the ventro-lateral funiculi (Bing et al, 1990).…”

mentioning

confidence: 98%

Organization of diencephalic projections from the medullary subnucleus reticularis dorsalis and the adjacent cuneate nucleus: A retrograde and anterograde tracer study in the rat

et al. 1998

View full text Add to dashboard Cite

The distribution and organization of diencephalic projections from the subnucleus reticularis dorsalis (SRD) and the neighbouring cuneate nucleus (Cu) were studied in the rat by using microinjections of Phaseolus vulgaris leucoagglutinin in SRD and Cu and wheat germ agglutinin-apo horseradish peroxidase-gold in some selected thalamic areas. As previously reported, the efferent projections from the Cu were essentially contralateral and terminated mainly in the ventroposterolateral thalamic nucleus. Less dense terminals from the Cu were also observed in the posterior thalamic group, the ventral aspect of the zona incerta and the caudal and dorsal portion of the reuniens area. Retrograde tracer injections in the medial ventroposterolateral thalamic nucleus labeled numerous cells in the contralateral Cu, with a smaller number in the gracile nucleus. From the SRD, terminals were observed in the lateral aspect of the ventromedial thalamic nucleus, the lateral parafascicular area and, to a lesser extent, in the ventral aspect of the zona incerta and the core of the reuniens area. Retrograde tracer injections in the lateral part of the ventromedial thalamic nucleus labeled cells in the caudal medulla, many of which were located in the dorsal-most aspect of the SRD throughout its caudo-rostral extent. The existence of SRD-thalamic connections reinforces the idea that the caudal reticular formation is an important nociceptive relay to the thalamus. Our data shed new light on old hypotheses suggesting that, in addition to spino-thalamic pathways, spino-reticulo-thalamic pathways may play an important role in distributing pain signals to the forebrain.

show abstract

Convergence of visceral and somatic inputs onto subnucleus reticularis dorsalis neurones in the rat medulla.

Cited by 40 publications

References 35 publications

Defining projections from the caudal pressor area of the caudal ventrolateral medulla

Defining projections from the caudal pressor area of the caudal ventrolateral medulla

Distribution and properties of visceral nociceptive neurons in rabbit cingulate cortex

Organization of diencephalic projections from the medullary subnucleus reticularis dorsalis and the adjacent cuneate nucleus: A retrograde and anterograde tracer study in the rat

Contact Info

Product

Resources

About