Convergence of plasmid-mediated Colistin and Tigecycline resistance in Klebsiella pneumoniae
Yujie Zhao,
Changrui Qian,
Jianzhong Ye
et al.
Abstract:ObjectiveThe co-occurrence of colistin and tigecycline resistance genes in Klebsiella pneumoniae poses a serious public health problem. This study aimed to characterize a K. pneumoniae strain, K82, co-harboring a colistin resistance gene (CoRG) and tigecycline resistance gene (TRG), and, importantly, investigate the genetic characteristics of the plasmid with CoRG or TRG in GenBank.MethodsK. pneumoniae strain K82 was subjected to antimicrobial susceptibility testing, conjugation assay, and whole-genome sequenc… Show more
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