Convergence of olfactory and gustatory connections onto the endopiriform nucleus in the rat

Fu, Wei; Sugai, Tokio; Yoshimura, Hiroshi; Onoda, Norihiko

doi:10.1016/j.neuroscience.2004.03.041

Cited by 34 publications

(29 citation statements)

References 38 publications

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“…2d). Retrogradely labelled cell bodies were found in relay areas of the olfactory system, which have been shown to receive inputs from the OB2324. Labelled cells were detected in the piriform cortex (5.5 ± 2.8% of DAPI-positive cells showed detectable levels of retroBead, n = 3 mice), dorsal endopiriform nucleus (11.4 ± 4.5% retrogradely traced cell bodies, n = 3 mice) and anterior olfactory area (14 and 2% retroBead-positive cells, 2 mice; Fig.…”

Section: Resultsmentioning

confidence: 93%

Organization of prefrontal network activity by respiration-related oscillations

Biskamp

Bartos

Sauer

2017

Sci Rep

178

206

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The medial prefrontal cortex (mPFC) integrates information from cortical and sub-cortical areas and contributes to the planning and initiation of behaviour. A potential mechanism for signal integration in the mPFC lies in the synchronization of neuronal discharges by theta (6–12 Hz) activity patterns. Here we show, using in vivo local field potential (LFP) and single-unit recordings from awake mice, that prominent oscillations in the sub-theta frequency band (1–5 Hz) emerge during awake immobility in the mPFC. These oscillation patterns are distinct from but phase-locked to hippocampal theta activity and occur synchronized with nasal respiration (hence termed prefrontal respiration rhythm [PRR]). PRR activity modulates the amplitude of prefrontal gamma rhythms with greater efficacy than theta oscillations. Furthermore, single-unit discharges of putative pyramidal cells and GABAergic interneurons are entrained by prefrontal PRR and nasal respiration. Our data thus suggest that PRR activity contributes to information processing in the prefrontal neuronal network.

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Section: Resultsmentioning

confidence: 93%

Organization of prefrontal network activity by respiration-related oscillations

Biskamp

Bartos

Sauer

2017

Sci Rep

178

206

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“…In fact, NPS receptors are also expressed in lower layers of the PC, indicating that they may form a functional NPS-responsive unit with the EPN/PC area. The previously observed involvement of the EPN in the integration of olfactory and gustatory information has led to the suggestion that it may via its efferent connections to the amygdala be involved in food selection and – more generally – in emotional reactions related to chemical sensation [17]. Moreover, the EPN is well known for its role in epileptogenic properties, and kindling-induced epileptiform potentials in PC slices were shown to originate in the EPN [18], [19].…”

Section: Discussionmentioning

confidence: 99%

Identification of a Neuropeptide S Responsive Circuitry Shaping Amygdala Activity via the Endopiriform Nucleus

et al. 2008

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Neuropeptide S (NPS) and its receptor are thought to define a set of specific brain circuits involved in fear and anxiety. Here we provide evidence for a novel, NPS-responsive circuit that shapes neural activity in the mouse basolateral amygdala (BLA) via the endopiriform nucleus (EPN). Using slice preparations, we demonstrate that NPS directly activates an inward current in 20% of EPN neurons and evokes an increase of glutamatergic excitation in this nucleus. Excitation of the EPN is responsible for a modulation of BLA activity through NPS, characterized by a general increase of GABAergic inhibition and enhancement of spike activity in a subset of BLA projection neurons. Finally, local injection of NPS to the EPN interferes with the expression of contextual, but not auditory cued fear memory. Together, these data suggest the existence of a specific NPS-responsive circuitry between EPN and BLA, likely involved in contextual aspects of fear memory.

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“…and to the central and lateral amygdaloid nuclei, but not to the insular cortex (Nakashima et al, 2000). Integrated olfactory and gustatory information may be also conveyed to APir by the endopiriform nucleus (Fu et al, 2004) and the anterior cortical and anterior basomedial nuclei (Petrovich et al, 1996).…”

Section: Functional Considerationsmentioning

confidence: 99%

Afferent connections of the amygdalopiriform transition area in the rat

Santiago

Shammah‐Lagnado

2005

J of Comparative Neurology

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The amygdalopiriform transition area (APir) is often considered part of the lateral entorhinal cortex (Entl). However, in contrast to Entl, APir densely innervates the central extended amygdala (EAc) and does not project to the dentate gyrus. In order to gain a more comprehensive understanding of these territories, the afferent connections of APir were examined in the rat with retrograde (cholera toxin B subunit or FluoroGold) and anterograde tracers (Phaseolus vulgaris leucoagglutinin) and compared to those of the neighboring Entl. The results suggest that APir and Entl are interconnected and receive topographically organized hippocampal projections. Both are targeted by the olfactory bulb, the piriform, posterior agranular insular and perirhinal cortices, the ventral tegmental area, dorsal raphe nucleus, and locus coeruleus. Most importantly, the data reveal that APir and Entl also have specific inputs and should be viewed as separate anatomical entities. The APir receives robust projections from structures affiliated with the EAc, including the anterior basomedial and posterior basolateral amygdaloid nuclei, the gustatory thalamic region, parasubthalamic nucleus, and parabrachial area. The Entl is a major recipient for amygdaloid projections from the medial part of the lateral nucleus and the caudomedial part of the basolateral nucleus. Moreover, the medial septum, subicular complex, nucleus reuniens, supramammillary region, and nucleus incertus, which are associated with the hippocampal system, preferentially innervate the Entl. These data underscore that APir processes olfactory and gustatory information and is tightly linked to EAc operations, suggesting that it may play a role in reward mechanisms, particularly in hedonic aspects of feeding.

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Convergence of olfactory and gustatory connections onto the endopiriform nucleus in the rat

Cited by 34 publications

References 38 publications

Organization of prefrontal network activity by respiration-related oscillations

Organization of prefrontal network activity by respiration-related oscillations

Identification of a Neuropeptide S Responsive Circuitry Shaping Amygdala Activity via the Endopiriform Nucleus

Afferent connections of the amygdalopiriform transition area in the rat

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