Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex

Aabedi, Alexander A; Kakaizada, Sofia; Young, Jacob S; Kaur, Jasleen; Wiese, Olivia; Valdivia, Claudia; Krishna, Saritha; Weyer-Jamora, Christina; Berger, Mitchel S.; Weissman, Daniel H.; Brang, David; Hervey-Jumper, Shawn L.

doi:10.1038/s41598-021-85802-5

Cited by 10 publications

(15 citation statements)

References 80 publications

(38 reference statements)

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“…In natural speech, visual articulations typically occur before the onset of speech-related sounds (typically within 40 - 200 ms of speech onset (33)). Because of this pre-articulatory visual information, visemes evoked increased beta suppression beginning before the expected phoneme onset time (−250 to 0 ms) [ t (5) = 2.78, p = .039, d = 1.13]. This is consistent with past research (15) and indicative of possible lateral(34) or feedback inputs (35–37) into the auditory system.…”

Section: Resultssupporting

confidence: 86%

“…Visual speech improves auditory speech perception during face-to-face conversations (1, 2). These benefits are strongest in noisy situations (3) and in individuals with hearing loss due to healthy aging (4), intrinsic brain tumor (5), stroke (6, 7), concussion (8, 9), or cochlear implants (10). However, there is limited understanding of how the brain enables vision to facilitate hearing processes.…”

Section: Introductionmentioning

confidence: 99%

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Auditory cortex encodes lipreading information through spatially distributed activity

Ganesan

Cao

Demidenko

et al. 2022

Preprint

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Face-to-face communication improves the quality and accuracy of heard speech, particularly in noisy environments. Silent lipreading modulates activity in auditory regions, which has been hypothesized to reflect the transformation and encoding of multiple forms of visual speech information used to support hearing processes. Evidence suggests visual timing information as one such signal encoded in auditory areas: seeing when a speaker's lips come together between words can help listeners parse word-level boundaries. However, it remains unclear how lipreading alters activity in the auditory system to improve speech perception at the single word-level. Using fMRI and intracranial electrodes in patients, here we show that silently lipread words can be classified from neural activity in auditory areas based on distributed spatial information. Lipread words evoked similar representations to the corresponding heard words, consistent with the prediction that automatic lipreading refines the tuning of auditory representations. Similar to heard words, lipread words varied in the distinctiveness of their neural representations in auditory cortex: e.g., the lipread words DIG and GIG evoked more similar neural activity in auditory cortex relative to the more perceptually distinct word FIG, suggesting that lipreading activity reflects probabilistic distributions as opposed to the unique identity of the lipread word. Notably, while visual speech has both excitatory and suppressive effects on auditory firing rates, classification was observed in both neural populations, consistent with the prediction that lipreading contributes to phoneme population tuning by both activating the corresponding representation and suppressing incorrect phonemic representations. These results support a model in which the auditory system combines the joint neural distributions evoked by heard and lipread words to generate a more precise estimate of what was said, particularly during noisy speech.

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Section: Resultssupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Auditory cortex encodes lipreading information through spatially distributed activity

Ganesan

Cao

Demidenko

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

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“…A variety of different methods have previously been used to isolate brain regions essential to naming, including lesion deficit mapping, [9][10][11][12][13] functional imaging, [14][15][16] and noninvasive electroencephalography (EEG). 17 More recently, studies using invasive electrocorticography (ECoG) have yielded a more precise delineation of the neurophysiological basis of word production.…”

Section: Introductionmentioning

confidence: 99%

Critical role of the ventral temporal lobe in naming

et al. 2023

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Objective Lexical retrieval deficits are characteristic of a variety of different neurological disorders. However, the exact substrates responsible for this are not known. We studied a large cohort of patients undergoing surgery in the dominant temporal lobe for medically intractable epilepsy (n = 95) to localize brain regions that were associated with anomia. Methods We performed a multivariate voxel‐based lesion–symptom mapping analysis to correlate surgical lesions within the temporal lobe with changes in naming ability. Additionally, we used a surface‐based mixed‐effects multilevel analysis to estimate group‐level broadband gamma activity during naming across a subset of patients with electrocorticographic recordings and integrated these results with lesion–deficit findings. Results We observed that ventral temporal regions, centered around the middle fusiform gyrus, were significantly associated with a decline in naming. Furthermore, we found that the ventral aspect of temporal lobectomies was linearly correlated to a decline in naming, with a clinically significant decline occurring once the resection extended 6 cm from the anterior tip of the temporal lobe on the ventral surface. On electrocorticography, the majority of these cortical regions were functionally active following visual processing. These loci coincide with the sites of susceptibility artifacts during echoplanar imaging, which may explain why this region has been previously underappreciated as the locus responsible for postoperative naming deficits. Significance Taken together, these data highlight the crucial contribution of the ventral temporal cortex in naming and its important role in the pathophysiology of anomia following temporal lobe resections. As such, surgical strategies should attempt to preserve this region to mitigate postoperative language deficits.

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“…The main attributing factor to the finding could be an influence of left frontal DLGG on the WM fibers. It has been established that IFOF, SLF‐II and AF played a crucial role in language function 34,35 . Particularly, according to the ‘dual stream’ theory of language processing, the IFOF, ILF and UF integrate information within the ventral stream where semantic and syntactic analyses predominate, whereas the SLF and AF belong to the dorsal stream where phonological and articulatory processing occur 36 .…”

Section: Discussionmentioning

confidence: 99%

Multiparametric mapping of white matter reorganizations in patients with frontal glioma‐related epilepsy

et al. 2023

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Aims: Epilepsy is a common symptom in diffuse lower-grade glioma (DLGG). The specific role of white matter (WM) alteration in patients with glioma-related epilepsy (GRE) is largely unknown. This study aims to investigate the reorganization of WM tracts and changes in structural networks related to GRE. Methods: Diffusion-weighted images were collected from 70 patients with left frontal DLGG (GRE = 33, non-GRE = 37) and 41 healthy controls (HC). Tractometry with TractSeg was applied to segment tracts and quantify fractional anisotropy (FA) along each tract. Structural network was constructed using constrained spherical deconvolution and probabilistic tractography. FA and network properties were compared among three groups. Results: Compared with HC, both GRE and non-GRE showed decreased FA in contralateral inferior fronto-occipital fasciculus, superior longitudinal fasciculus II and arcuate fasciculus, increased nodal efficiency in contralateral nodes of frontal-parietal and limbic networks, whereas decreased degree centrality and betweenness centrality in nodes of dorsal temporal lobe and rostral middle frontal gyrus (rMFG). Additionally, when compared GRE with non-GRE, increased FA in contralateral corticospinal tract (CST) and lower betweenness centrality in paracentral lobule (PCL) in GRE (all p < 0.05 after Bonferroni correction). Conclusion: This study indicates that patients with left frontal DLGG exhibit complex WM reorganization, and the altered regions mainly concentrated in the language, frontal-parietal and limbic networks. Moreover, the preserved integrity in | 2367 ZHANG et al.

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Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex

Cited by 10 publications

References 80 publications

Auditory cortex encodes lipreading information through spatially distributed activity

Auditory cortex encodes lipreading information through spatially distributed activity

Critical role of the ventral temporal lobe in naming

Multiparametric mapping of white matter reorganizations in patients with frontal glioma‐related epilepsy

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