Convergence of Dissipation and Impedance Analysis of Quartz Crystal Microbalance Studies

Zhang, Yaozhong; Du, Binyang; Chen, Xinan; Ma, Hongwei

doi:10.1021/ac8019762

Cited by 38 publications

(34 citation statements)

References 44 publications

(106 reference statements)

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“…In that model, the thickness of layer II (also called the "solidified liquid layer", Scheme 1) was determined by the thickness of a swollen biomolecule layer, such as the thickness of immobilized proteins, DNA or polymer chains. The measured frequency change was fitted [23] according to eq. (1) to separate mass-induced and viscoelasticity induced f, and then the mass-induced f was converted to mass change according to eq.…”

Section: Introductionmentioning

confidence: 99%

The change in thickness of the solidified liquid layer rather than the immobilized mass determines the frequency response of a quartz crystal microbalance

Fang

et al. 2011

Sci. China Chem.

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The "solidified liquid layer" model has been examined using a quartz crystal microbalance (QCM) with a polymeric matrix. The model is shown to give a reasonable explanation for the following experimental observations: (i) The opposite response of the QCM and surface plasmon resonance (SPR) for the activation process; (ii) the marked difference in the responses for IgG/anti-IgG interaction between QCM and SPR. Theoretical analysis and experimental results indicated that QCM is sensitive to the thickness change of the "solidified liquid layer" but not the mass of captured biomolecules (i.e., the immobilized mass), implying caution must be taken in interpreting QCM results. quartz crystal microbalance, solidified liquid layer, matrix, biosensor

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Section: Introductionmentioning

confidence: 99%

The change in thickness of the solidified liquid layer rather than the immobilized mass determines the frequency response of a quartz crystal microbalance

Fang

et al. 2011

Sci. China Chem.

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“…2a), (2) the surface-initiated polymerization (SIP) to prepare the finely tuned polymer brushes12 (Fig. 2b) and (3) the quartz crystal microbalance (QCM) that is sensitive to interfacial changes131415 (Fig. 3a).…”

Section: Resultsmentioning

confidence: 99%

A proton shelter inspired by the sugar coating of acidophilic archaea

Wang

Cai

et al. 2012

Sci Rep

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The acidophilic archaeons are a group of single-celled microorganisms that flourish in hot acid springs (usually pH < 3) but maintain their internal pH near neutral. Although there is a lack of direct evidence, the abundance of sugar modifications on the cell surface has been suggested to provide the acidophiles with protection against proton invasion. In this study, a hydroxyl (OH)-rich polymer brush layer was prepared to mimic the OH-rich sugar coating. Using a novel pH-sensitive dithioacetal molecule as a probe, we studied the proton-resisting property and found that a 10-nm-thick polymer layer was able to raise the pH from 1.0 to > 5.0, indicating that the densely packed OH-rich layer is a proton shelter. As strong evidence for the role of sugar coatings as proton barriers, this biomimetic study provides insight into evolutionary biology, and the results also could be expanded for the development of biocompatible anti-acid materials.

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“…34 Furthermore, convergence relationships of dissipation analysis and the analysis based on f and HBHW, have also been reported. 35 The proposed method described here gives not only information about f r and , but also the wide-bandwidth transfer function of the resonator (with a much simpler setup than a network analyzer). Potentially, this could offer more useful information than just relying on the f r and .…”

Section: Theoretical Underpinnings and Simulation Resultsmentioning

confidence: 99%

A new method for wideband characterization of resonator-based sensing platforms

Munir

Wathen

Hunt

2011

Review of Scientific Instruments

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A new approach to the electronic instrumentation for extracting data from resonator-based sensing devices (e.g., microelectromechanical, piezoelectric, electrochemical, and acoustic) is suggested and demonstrated here. Traditionally, oscillator-based circuitry is employed to monitor shift in the resonance frequency of the resonator. These circuits give a single point measurement at the frequency where the oscillation criterion is met. However, the resonator response itself is broadband and contains much more information than a single point measurement. Here, we present a method for the broadband characterization of a resonator using white noise as an excitation signal. The resonator is used in a two-port filter configuration, and the resonator output is subjected to frequency spectrum analysis. The result is a wideband spectral map analogous to the magnitude of the S21 parameters of a conventional filter. Compared to other sources for broadband excitation (e.g., frequency chirp, multisine, or narrow time domain pulse), the white noise source requires no design of the input signal and is readily available for very wide bandwidths (1 MHz-3 GHz). Moreover, it offers simplicity in circuit design as it does not require precise impedance matching; whereas such requirements are very strict for oscillator-based circuit systems, and can be difficult to fulfill. This results in a measurement system that does not require calibration, which is a significant advantage over oscillator circuits. Simulation results are first presented for verification of the proposed system, followed by measurement results with a prototype implementation. A 434 MHz surface acoustic wave (SAW) resonator and a 5 MHz quartz crystal microbalance (QCM) are measured using the proposed method, and the results are compared to measurements taken by a conventional bench-top network analyzer. Maximum relative differences in the measured resonance frequencies of the SAW and QCM resonators are 0.0004% and 0.002%, respectively. The ability to track a changing sensor response is demonstrated by inducing temperature variations and measuring resonance frequency simultaneously using the proposed technique in parallel with a network analyzer. The relative difference between the two measurements is about 5.53 ppm, highlighting the impressive accuracy of the proposed system. Using commercially available digital signal processors (DSPs), we believe that this technique can be implemented as a system-on-a-chip solution resulting in a very low cost, easy to use, portable, and customizable sensing system. In addition, given the simplicity of the signal and circuit design, and its immunity to other common interface concerns (injection locking, oscillator interference, and drift, etc.), this method is better suited to accommodating array-based systems.

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Convergence of Dissipation and Impedance Analysis of Quartz Crystal Microbalance Studies

Cited by 38 publications

References 44 publications

The change in thickness of the solidified liquid layer rather than the immobilized mass determines the frequency response of a quartz crystal microbalance

The change in thickness of the solidified liquid layer rather than the immobilized mass determines the frequency response of a quartz crystal microbalance

A proton shelter inspired by the sugar coating of acidophilic archaea

A new method for wideband characterization of resonator-based sensing platforms

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