2015
DOI: 10.1002/mrm.25901
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Conventions and nomenclature for double diffusion encoding NMR and MRI

Abstract: Stejskal and Tanner's ingenious pulsed field gradient design from 1965 has made diffusion NMR and MRI the mainstay of most studies seeking to resolve microstructural information in porous systems in general and biological systems in particular. Methods extending beyond Stejskal and Tanner's design, such as double diffusion encoding (DDE) NMR and MRI, may provide novel quantifiable metrics that are less easily inferred from conventional diffusion acquisitions. Despite the growing interest on the topic, the term… Show more

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Cited by 171 publications
(209 citation statements)
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“…Even though these limitations have been known for over 20 years, there have been no improvements to the model due to the mathematical intractability of the problem. AXR imaging (Lasič et al, 2011; has recently been introduced as an alternative to estimating τ i via Kärger model; however it requires specialised double diffusion encoding imaging sequences (DDE) (Shemesh et al, 2016) and it again relies on strong assumptions about the compartmentation of water into a 'fast' and 'slow' pool. The estimated AXR parameter also conflates τ i with intra-axonal volume fraction f, making it difficult to disentangle the origin of any measured change.…”
Section: Introductionmentioning
confidence: 99%
“…Even though these limitations have been known for over 20 years, there have been no improvements to the model due to the mathematical intractability of the problem. AXR imaging (Lasič et al, 2011; has recently been introduced as an alternative to estimating τ i via Kärger model; however it requires specialised double diffusion encoding imaging sequences (DDE) (Shemesh et al, 2016) and it again relies on strong assumptions about the compartmentation of water into a 'fast' and 'slow' pool. The estimated AXR parameter also conflates τ i with intra-axonal volume fraction f, making it difficult to disentangle the origin of any measured change.…”
Section: Introductionmentioning
confidence: 99%
“…Diffusion Δ1 and Δ2 are the times between the diffusion gradient pulses in q (1) and q (2) , respectively. and are the corresponding gradient strengths.…”
Section: Methodsmentioning
confidence: 99%
“…Homospoil gradient pulse during longitudinal storage shown in solid black. All diffusion gradients (G (1) and G (2) ) have equal duration and are trapezoidal in shape.…”
Section: Methodsmentioning
confidence: 99%
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