Conventional versus fibrin-glue-augmented arterial microanastomosis: An experimental study

Hanneur, Malo Le; Chaves, Camilo; Lauthe, O.; Salabi, Vincent; Bouché, P.-A.; Fitoussi, F.

doi:10.1016/j.hansur.2022.08.006

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…For example, cyanoacrylate adhesives, brands like Dermabond and SurgiSeal, facilitate rapid bonding and microbial protection, though their inherent brittleness and cytotoxicity can pose limitations in vascular contexts [ [95] , [96] , [97] ]. Fibrin sealants, with Tisseel and Evicel leading the pack, emulate the clotting response of the body, offering flexible seals particularly well-suited for internal vascular connections [ [98] , [99] , [100] ]. BioGlue combines bovine serum albumin with glutaraldehyde to form robust bonds, fortifying anastomotic junctions [ [101] , [102] , [103] ].…”

Section: Sutureless Anastomotic Approaches Undergoing Developmentmentioning

confidence: 99%

“…Therefore, it is used solely as a supplemental adhesive. When used as an adjunct, it has been found to reduce bleeding time, substantially increase tensile strength, and decrease the number of required sutures [ [98] , [99] , [100] ]. Recently, Hanneur et al evaluated its effectiveness in end-to-end arterial microvascular anastomosis using minimal sutures.…”

Section: Sutureless Anastomotic Approaches Undergoing Developmentmentioning

confidence: 99%

“…In their study involving eight anastomoses on seven male rats across different arteries, including femoral, iliac, carotid, and subrenal aorta, the augmented anastomoses with fibrin glue proved significantly quicker (by 10.7 ± 3.2 min), resulted in less blood loss (1.3 ± 0.9 g), and achieved higher quality scores (2.6 ± 2.5 points more) than the conventional technique. Patency rates were similar across both techniques, but notably, three out of seven augmented anastomoses in the femoral subgroup were non-permeable [ 100 ].…”

Section: Sutureless Anastomotic Approaches Undergoing Developmentmentioning

confidence: 99%

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Sutureless vascular anastomotic approaches and their potential impacts

Ribaudo,

He,

Madira

et al. 2024

Bioactive Materials

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Section: Sutureless Anastomotic Approaches Undergoing Developmentmentioning

confidence: 99%

Section: Sutureless Anastomotic Approaches Undergoing Developmentmentioning

confidence: 99%

Section: Sutureless Anastomotic Approaches Undergoing Developmentmentioning

confidence: 99%

See 1 more Smart Citation

Sutureless vascular anastomotic approaches and their potential impacts

Ribaudo,

He,

Madira

et al. 2024

Bioactive Materials

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Validation of Novel Microsurgical Vessel Anastomosis Techniques: A Systematic Review

Sadigh,

Mechri,

Jain

et al. 2024

J Reconstr Microsurg

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Introduction: Thorough validation of novel microsurgical techniques is deemed essential before their integration into clinical practice. To achieve proper validation, the design of randomized controlled trials (RCTs) should be undertaken, accompanied by the execution of comprehensive statistical analyses, including confounder adjustment and power analysis. This systematic review aims to provide an encompassing overview of the validation methodologies employed in microsurgical studies, with a specific focus on innovative vessel anastomosis techniques. Methods: A literature search was conducted in PubMed for articles describing the validation of novel microsurgical vessel anastomosis techniques in animal or human subjects. Results: The literature search yielded 6,658 articles. 6,564 articles were excluded based on title and abstract. Ninety-four articles were assessed for full-text eligibility. Forty-eight articles were included in this systematic review. Out of 30 comparative studies, nine studies validated novel modified interrupted suture techniques, six studies modified continuous techniques, six studies modified sleeve anastomosis techniques, one study a modified vesselotomy technique, seven studies sutureless techniques, and one study a modified lymphaticovenular anastomosis technique. Twenty-eight studies contained animals (n=1,998). Fifteen animal studies were RCTs. Two studies contained human/cadaveric subjects (n=29). Statistical power-analysis and confounder adjustment were performed in one animal study. Out of eighteen non-comparative studies, five studies validated novel modified interrupted suture techniques, one study a modified continuous technique, two studies modified sleeve anastomosis techniques, four studies modified vesselotomy techniques, four studies sutureless techniques, and two studies modified lymphaticovenular anastomosis techniques. Ten studies contained animal subjects (n=320), with two RCTs. Eight studies contained human subjects (n=173). Statistical power-analysis and confounder adjustment were performed in none of the animal or human studies. Conclusion: The current methods of microsurgical technique validation should be reconsidered due to poor study design. Statistical analysis including confounder adjustment and power-analysis should be performed as a standard method of novel technique validation.

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Conventional versus fibrin-glue-augmented arterial microanastomosis: An experimental study

Cited by 2 publications

References 22 publications

Sutureless vascular anastomotic approaches and their potential impacts

Sutureless vascular anastomotic approaches and their potential impacts

Validation of Novel Microsurgical Vessel Anastomosis Techniques: A Systematic Review

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