Conventional Synthesis of Amphiphilic Block Copolymer Utilized for Polymeric Micelle by Mechanochemical Solid-State Polymerization

The mechanochemical synthesis of polymers

“…125,138 Continuing studies by Oprea in the 1980s and by Kuzuya in the 1990s covered many of the vinyl monomers known to undergo polymerisation (Scheme 1). 18 The adopted strategy was used to convert (meth)acrylates, 19,130,[139][140][141][142][143][144][145] (meth)acrylamides, 125,126,141,146 styrenes, 128,141,[147][148][149][150] and other structurally diverse vinyl monomers [149][150][151][152] into the corresponding polymers under solvent-free ball-milling conditions. Moreover, the copolymerisation of these monomers has also been investigated, 125,130,140,149,[153][154][155] as is discussed below.…”

“…Kuzuya and coworkers also used the macroradical formation and concurrent polymerisation of solid-state monomers to produce amphiphilic polymers. Specifically, the ball milling of polymethacrylate, 142,144 poly(4-vinylpyridine), 170,176 or cellulose 168 produced the corresponding macroradicals that initiated the radical polymerisation of solid-state monomers to afford block copolymers of various compositions.…”

Novel pH-Responsive Polymeric Micelles Prepared through Self-assembly of Amphiphilic Block Copolymer with Poly-4-vinylpyridine Block Synthesized by Mechanochemical Solid-State Polymerization

“…[10][11][12][13] We previously reported the synthesis and drug release profiles of various polymeric prodrugs prepared by mechanochemical solid-state polymerization carried out through vibratory ball-milling of solid monomers in a metallic vessel under anaerobic conditions. [14][15][16][17][18][19][20][21][22][23][24][25][26] A series of studies revealed that this method is applicable to the preparation of a wide variety of vinyl monomers of important classes of bioactive compounds with different physicochemical properties. The method also provides a simple, novel means of synthesizing functionalized polymers in a totally dry process.…”

“…We have also studied the conventional synthesis and drug release profiles of polymeric micelles formed from amphiphilic block copolymers via mechanochemical polymerization. 26) In a previous study, we used mechanochemical solid-state polymerization to synthesize a novel amphiphilic copolymer containing basic and hydrophobic blocks.…”

Characterization of Novel pH-Sensitive Polymeric Micelles Prepared by the Self-Assembly of Amphiphilic Block Copolymer with Poly-4-vinylpyridine Block Synthesized by Mechanochemical Solid-State Polymerization

“…[14][15][16][17][18][19][20][21][22][23][24][25][26] The mechanochemical solid-state polymerizations was conducted by vibratory ballmilling of a solid monomer in a metallic container under anaerobic conditions. There are several advantages to mechanochemical solid-state polymerization: the reaction proceeds in dry conditions and quantitatively yields polymers with a narrow molecular weight distribution, thereby reducing work-up such as purification and separation.…”