Conventional Primary Central Chondrosarcoma of the Pelvis

Bus, Michaël P. A.; Campanacci, Domenico Andrea; Albergo, José I.; Leithner, Andreas; Sande, Michiel A. J. van de; Gaston, Czar Louie; Caff, Giuseppe; Mettelsiefen, Jan; Capanna, Rodolfo; Tunn, Per‐Ulf; Jeys, Lee; Dijkstra, P. D. Sander

doi:10.2106/jbjs.17.00105

Cited by 74 publications

(52 citation statements)

References 46 publications

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“…Malignant pelvic bone tumors are among the most challenging problems in orthopedic oncology 9. It’s difficult to achieve wide marginal resection due the complex anatomy of the pelvis, potentially rendering a high risk of local recurrence and vital structures injury.…”

Section: Discussionmentioning

confidence: 99%

Improved virtual surgical planning with 3D-multimodality image for malignant giant pelvic tumors

Fang

Xiong

et al. 2018

CMAR

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We sought to assess the early clinical outcome of 3D-multimodality image (3DMMI)based virtual surgical planning for resection and reconstruction of malignant giant pelvic tumors. Patients and methods: In this retrospective case-control study, surgery was planned and performed with 3DMMI-based patient-specific instruments (PSI) in 13 patients with giant pelvic malignancy and without 3DMMI-based PSI in the other 13 patients. In the 3DMMI group, 3DMMI was utilized, taking advantages of computed tomography (CT), contrast-enhanced CT angiography (CTA), contrast-enhanced magnetic resonance imaging (MRI), contrast-enhanced magnetic resonance neurography (MRN), which could reveal the whole tumor and all adjacent vital structures. Based on these 3DMMI, virtual surgical planning was conducted and the corresponding PSI was then designed. The median follow-up was 8 (3-24) months. The median age at operation was 37.5 (17-64) years. The mean tumor size in maximum diameter was 13.3 cm. Surgical margins, intraoperative and postoperative complications, duration of surgery, and intra-operative blood loss were analyzed. Results: In the non-3DMMI group, the margins were wide in six patients (6/13), marginal in four (4/13), wide-contaminated in two (2/13), and intralesional in one (1/13). In the 3DMMI group, the margins were wide in 10 patients (10/13), marginal in three (3/13), and there were no wide-contaminated or intralesional margins. The 3DMMI group achieved shorter duration of surgery (P=0.354) and lower intraoperative blood loss (P=0.044) than the non-3DMMI group. Conclusion: The 3DMMI-based technique is advantageous to obtain negative surgical margin and decrease surgical complications related to critical structures injury for malignant giant pelvic tumor.

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Section: Discussionmentioning

confidence: 99%

Improved virtual surgical planning with 3D-multimodality image for malignant giant pelvic tumors

Fang

Xiong

et al. 2018

CMAR

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“…Zu der intermediären Gruppe gehört aufgrund des lokal aggressiven Wachstumsmusters auch der atypische kartilaginäre Tumor (ACT) der Extremitäten [9]. Während in der WHO-Klassifikation von 2013 der Begriff "Chondrosarkom Grad I" komplett durch "ACT" ersetzt und in die intermediäre Gruppe eingeordnet wurde, werden in der neuen WHO-Klassifikation von 2020 beide Begriffe in Abhängigkeit von der Lokalisation verwendet [6,10]: Bei Lokalisation im Extremitätenskelett (lange und kurze Röhrenknochen) werden die Tumoren als ACT bezeichnet und der intermediären Gruppe zugeordnet; bei Lokalisation im Achsensekelett (einschließlich Becken und Schädelbasis) werden die Tumoren bei gleicher Histologie als Chondrosarkome Grad I bezeichnet und der malignen Gruppe zugeordnet, um das differente biologische Verhalten abzubilden [11,12].…”

Section: Who-klassifikationunclassified

“…Man unterscheidet zwischen den häufigeren konventionellen Chondrosarkomen und selteneren Subtypen (▶ Tab. 3; ▶ Abb 11,12)…”

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Chondrogenic Bone Tumors: The Importance of Imaging Characteristics

Engel

Herget

Füllgraf

et al. 2020

Rofo

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Background Chondrogenic tumors are the most frequent primary bone tumors. Malignant chondrogenic tumors represent about one quarter of malignant bone tumors. Benign chondrogenic bone tumors are frequent incidental findings at imaging. Radiological parameters may be helpful for identification, characterization, and differential diagnosis. Methods Systematic PubMed literature research. Identification and review of studies analyzing and describing imaging characteristics of chondrogenic bone tumors. Results and conclusions The 2020 World Health Organization (WHO) classification system differentiates between benign, intermediate (locally aggressive or rarely metastasizing), and malignant chondrogenic tumors. On imaging, typical findings of differentiated chondrogenic tumors are lobulated patterns with a high signal on T2-weighted magnetic resonance imaging (MRI) and ring- and arc-like calcifications on conventional radiography and computed tomography (CT). Depending on the entity, the prevalence of this chondrogenic pattern differs. While high grade tumors may be identified due to aggressive imaging patterns, the differentiation between benign and intermediate grade chondrogenic tumors is challenging, even in an interdisciplinary approach. Key Points: Citation Format

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“…According to the literature, the local recurrence rate of pelvic CS is 18–45% [ 7 – 9 , 15 , 20 – 23 ]. In this study, the local recurrence rate of the primary and secondary CS group were 37.0 and 34.6%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the prognosis of patients in the secondary CS group was significantly better than that in the primary group, with a 5-year survival rate of 91.6 and 57% ( P = 0.003), respectively, which is consistent with the results of Ozaki et al [ 19 ]. Although it has been reported that the prognosis of CS is related to surgical resection margin [ 15 , 20 , 21 ], tumor size [ 20 ], age [ 22 ], local recurrence [ 22 ], surgical type [ 9 ], tumor stage [ 15 ], and tumor location [ 9 , 21 ]. However, in this study, we conducted a multivariate analysis of all patients with pelvic CS and found that pathological tumor grade, but not tumor type (primary and secondary), was an independent risk factor for prognosis (Table 5 ).…”

Section: Discussionmentioning

confidence: 99%

Differences in clinical characteristics and tumor prognosis between primary and secondary conventional pelvic chondrosarcoma

et al. 2020

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Background Chondrosarcoma (CS) most commonly involves the pelvis. This study aimed to analyze differences in clinical characteristics and prognostic factors between primary and secondary conventional pelvic CS, and provide reference for clinical diagnosis and treatment. Methods Eighty patients (54 primary cases and 26 secondary cases) with pelvic CS were included in this retrospective study. The tumor site, Enneking stage, soft tissue mass, margin, initial tumor grade, incidence of local recurrence and distant metastasis were evaluated. Kaplan-Meier method was used to calculate the overall survival rate. X2 test and log-rank test were used for univariate analysis, and Cox test was used in multivariate analysis. Results The average age of patients with secondary CS was significantly younger than that of patients with primary CS (P < 0.001). The soft tissue mass of patients with secondary CS was significantly larger than that of patients with primary CS (P = 0.002). There was a significant difference in initial tumor pathologic grade between the two groups (P = 0.002). No statistically significant difference was observed in the local recurrence rate between the two groups. The median recurrence time of patients with primary CS after the first treatment was significantly shorter than that of patients with secondary CS (P < 0.001). The overall survival rate of patients with secondary CS was much higher than that of patients with primary CS (P = 0.003). Cox regression analysis showed that the initial tumor grade was an independent factor in the overall survival rate of patients with CS. Conclusion There were significant differences in age, soft tissue mass, initial tumor grade, and overall survival rate between the two groups. The overall survival rate of pelvic CS was related to the initial tumor grade of CS.

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Conventional Primary Central Chondrosarcoma of the Pelvis

Abstract: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Cited by 74 publications

References 46 publications

Improved virtual surgical planning with 3D-multimodality image for malignant giant pelvic tumors

Improved virtual surgical planning with 3D-multimodality image for malignant giant pelvic tumors

Chondrogenic Bone Tumors: The Importance of Imaging Characteristics

Differences in clinical characteristics and tumor prognosis between primary and secondary conventional pelvic chondrosarcoma

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