Conventional IVF revisited: Is ICSI better for non-male factor infertility? Randomized controlled double blind study

Işıkoğlu, Mete; Avci̇, Aysenur; Cevi̇ren, Ayse Kendi̇rci̇; Aydınuraz, Batu; Ata, Barış

doi:10.1016/j.jogoh.2020.101990

Cited by 20 publications

(29 citation statements)

References 28 publications

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“…They found in their cohort of ICSI (advanced age, history of poor fertilization, repetitive implantation failure, endometriomas, low oocyte quality, and low oocyte yield; n = 142) that the TFF did not vary, but normal FR rate did improve with ICSI (83.4% and 79.1%, p = 0.04, respectively) [12]. Most recently, a 2020 RCT assessing NMF with sibling oocytes did find a slightly higher TFF in IVF cases (10 cases); however, they did not analyze LBR [13]. Please see Table 1.…”

Section: Unselected Patientmentioning

confidence: 97%

The Impact of Intracytoplasmic Sperm Injection in Non-Male Factor Infertility—A Critical Review

Glenn

Kotlyar

Seifer

2021

JCM

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Intracytoplasmic sperm injection (ICSI) was originally designed to overcome barriers due to male factor infertility. However, a surveillance study found that ICSI use in non-male factor infertility increased from 15.4% to 66.9% between 1996 and 2012. Numerous studies have investigated fertilization rate, total fertilization failure, and live birth rate per cycle (LBR), comparing the use of ICSI versus conventional in vitro fertilization (IVF) for non-male factor infertility. The overwhelming conclusion shows no increase in fertilization rate or LBR per cycle with the use of ICSI for non-male factor infertility. The overuse of ICSI is likely related to the desire to avoid a higher rate of total fertilization failure in IVF. However, data supporting the benefit of using ICSI for non-male factor infertility is lacking, and 33 couples would need to be treated with ICSI unnecessarily to avoid one case of total fertilization failure. Such practice increases the cost to the patient, increases the burden on embryologist’s time, and is a misapplication of resources. Additionally, there remains conflicting data regarding the safety of offspring conceived by ICSI and potential damage to the oocyte. Thus, the use of ICSI should be limited to those with male factor infertility or a history of total fertilization factor infertility due to uncertainties of potential adverse impact and lack of proven benefit in non-male factor infertility.

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Section: Unselected Patientmentioning

confidence: 97%

The Impact of Intracytoplasmic Sperm Injection in Non-Male Factor Infertility—A Critical Review

Glenn

Kotlyar

Seifer

2021

JCM

View full text Add to dashboard Cite

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“…Given the relatively recent surge in the safety and success of frozen embryo transfers, studies that compare ICSI with conventional insemination have not used this metric extensively. However, several studies have concluded that the per oocyte fertilization rate is higher with ICSI, which would lend support to the argument of higher usable embryos (25,112). Usable embryos, either transferred or frozen, should be a metric used in studies moving forward.…”

Section: Intracytoplasmic Sperm Injection For Few (Continued)mentioning

confidence: 98%

Intracytoplasmic sperm injection for all or for a few?

Franasiak

Polyzos

Neves

et al. 2022

Fertility and Sterility

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“…Ovarian stimulation, fertilisation, embryo transfer and pregnancy assessment: Ovarian stimulation, fertilisation, embryo transfer and pregnancy assessment were done as described elsewhere (Isikoglu et al, 2020). Brie y, initial daily gonadotropin dose was de ned as 225-300 IU/day depending on the body mass index and the previous history of the patients.…”

Section: Study Populationmentioning

confidence: 99%

“…Hence, it is crucial to clarify the rational fundamentals of choosing the right insemination technique. Recently, we published our results comparing the laboratory and clinical outcome of ICSI with those of C-IVF in all non-male factor cases (Isikoglu et al, 2020). Since we found similar outcome for both C-IVF and ICSI in the mentioned randomized controlled study, we decided to further analyse our clinical results for a particular subgroup of patients with poor ovarian response (POR) in order to clarify if lower number of oocytes is a drawback for proceeding to C-IVF.…”

Section: Introductionmentioning

confidence: 99%

Comparison of ICSI and conventional IVF in non-male factor patients with less than four oocytes

Işıkoğlu

Cevi̇ren

Çetin

et al. 2022

Arch Gynecol Obstet

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Background: We aimed to analyse our clinical results for a particular subgroup of patients with poor ovarian response (POR) in order to clarify if lower number of oocytes is a drawback for proceeding to C-IVF Materials and methods: In this retrospective study, patient les of all couples (#1733) who underwent oocyte retrieval between January 2017 and December 2019 were reviewed and 191 cases diagnosed with non-male factor infertility in which ≤3 cumulus-oocyte-complexes available for fertilisation were analysed. Exclusion criteria were: woman age>42, patients with a history of previous ART trial, prenatal genetic testing cycles and couples undergoing total cryopreservation for any indication. Three groups were constructed depending on the method of fertilisation and on semen quality as follows: IVF non-male factor (Group 1,n=77); ICSI non-male factor (Group 2, n=65); ICSI male factor-ICSI/MF n=49 according to WHO reference values. Main outcome parameters were: fertilisation rate, implantation rate and live birth rate.Results: Fertilisation rate per collected COC was signi cantly higher in group 1 compared to the other two groups (85,68%, 72,58%, 73,33% respectively, p=0,004). FR per inseminated oocyte also tended to be higher in group 1 but not reaching a statistically signi cant level. Both techniques yielded similar implantation rates (20,42%, 28,49%, 23,33% respectively, p=0,407) and live birth rates (26,8%, 30,6%, 31,1% respectively, p=0.643).Conclusions: In the presence of normal semen parameters, low egg number is not an indication to perform ICSI. The choice of fertilisation method should be based primarily on semen quality, in combination with the patient's previous history regardless of the ovarian reserve.

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Conventional IVF revisited: Is ICSI better for non-male factor infertility? Randomized controlled double blind study

Cited by 20 publications

References 28 publications

The Impact of Intracytoplasmic Sperm Injection in Non-Male Factor Infertility—A Critical Review

The Impact of Intracytoplasmic Sperm Injection in Non-Male Factor Infertility—A Critical Review

Intracytoplasmic sperm injection for all or for a few?

Comparison of ICSI and conventional IVF in non-male factor patients with less than four oocytes

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