Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trial

Bhattacharya, Siladitya; Hamilton, Mark; Shaaban, Mamdouh M.; Khalaf, Yakoub; Seddler, M.; Ghobara, Tarek; Braude, Peter; Kennedy, Rebekah; Rutherford, Anthony J.; Hartshorne, Geraldine M.; Templeton, Alexander Allan

doi:10.1016/s0140-6736(00)05179-5

Cited by 284 publications

(224 citation statements)

References 24 publications

Supporting

Mentioning

200

Contrasting

Unclassified

Order By: Relevance

“…Though it has been suggested that 6-10 oocytes is the ideal quantity to optimize the number of embryos ultimately transferred [21], retrospective analyses of poor response cycles and subsequent fertilization and pregnancy rates suggest that embryo transfer is still possible in this patient population and cycles should not be cancelled [19,22,23]. While there have been prospective trials to compare IVF outcomes in CI versus ICSI, women with poor ovarian response [24] or previous low responders [25] have had cycles cancelled or have been excluded. In couples without poor response to COH, ICSI has no proven benefit over CI and is a more invasive and expensive technique [24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Should ICSI be recommended routinely in patients with four or fewer oocytes retrieved?

Luna

Bigelow

Duke

et al. 2011

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose To determine if patients with a low response to controlled ovarian hyperstimulation during IVF benefit from intracytoplasmic sperm injection (ICSI) Methods Retrospective analysis of 350 IVF cycles in which four or fewer oocytes were retrieved. Severe male factor cases were excluded from analysis. Conventional insemination (CI) and ICSI were compared, with primary outcome measures of fertilization rate, implantation rate, clinical pregnancy rate per embryo transfer, and pregnancy loss rate. Result(s) Fertilization rates per oocyte retrieved for CI and ICSI were comparable (51.5% vs. 51.8%). Parallel implantation rates (22% vs. 25%), clinical pregnancy rates (32.8% vs. 33.3%), and loss rates (26.7% vs. 39.5%) were also noted. No difference in cancelled cycles was reported. Conclusion(s) Our results demonstrate that in the presence of normal semen parameters, low egg number is not an indication to perform ICSI.

show abstract

Section: Discussionmentioning

confidence: 99%

Should ICSI be recommended routinely in patients with four or fewer oocytes retrieved?

Luna

Bigelow

Duke

et al. 2011

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…This approach is often recommended despite the data that shows that fertilization rate and treatment outcome should be comparable with IVF and ICSI when the semen parameters are in the normal range and ICSI improves fertilization rates only when the semen parameters are borderline or when the morphology is poor [19][20][21][22]. Several studies have reported lower fertilization rates with IVF versus ICSI and a higher risk for complete fertilization failure with IVF among couples with unexplained infertility undergoing IVF following failed IUIs [15][16][17][18]23]. Ruiz et al, on the other hand found no significant difference between IVF and ICSI fertilization rates among women with unexplained infertility in their prospective randomized trial [24].…”

Section: Discussionmentioning

confidence: 99%

The role of hyaluronic acid binding assay in choosing the fertilization method for patients undergoing IVF for unexplained infertility

Kovács

Kováts

Sajgo

et al. 2010

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose Patients with unexplained infertility may have fertilization problems. Split fertilization (ICSI and conventional IVF on sibling oocytes) is often used to avoid poor fertilization. Our aim was to assess the ability of hyaluronic acid binding (HA-binding) assay to predict spontaneous fertilization during IVF. Methods Prospective, blinded, controlled trial. Patients undergoing their first IVF cycle for unexplained infertility were eligible. Split fertilization was used. IVF and ICSI fertilization rates and embryo development based on 3 HAbinding cut-offs (< 60%; 60-80%; >80%) were compared. Results ICSI fertilization was higher than IVF, but none of the HA-binding cut-off levels predicted those cases where IVF was less effective, therefore ICSI only would have lead to improved outcome. Embryo development and morphology were similar in all cut-off groups. Conclusions HA-binding did not predict spontaneous fertilization in patients with unexplained infertility undergoing IVF treatment. When it was used for "screening" it did not help to select the method of fertilization.

show abstract

“…npg In Europe, ICSI is the most frequently used procedure [12], although it offers no advantage over conventional IVF in the absence of sperm dysfunction [13] and there are concerns about the health of the offspring [14]. Here again, the effect of semen quality on the outcome is a continuum.…”

Section: The Probabilistic Nature Of Human Fertilitymentioning

confidence: 99%

Comments on the release of the 5th edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen

Ford¹

2010

Asian J Androl

269

View full text Add to dashboard Cite

The authors of the World Health Organization Semen Analysis Manual are to be congratulated on producing a new edition; it is an essential tool to disseminate good practice in andrology. However, the tests described have poor prognostic power to predict a man's fertility and show little about the underlying causes of sub-fertility. This commentary urges a revival of research into the diagnosis of male fertility. It suggests that fertility should be regarded as a continuum and that the artificial binary division between fertile and infertile should be abandoned. Models to predict a sub-fertile couple's chance of conception in a year should be developed on the basis of prospective data. These models would allow for sophisticated decision making about management. The future lies in the identification of tests to detect underlying pathologies open to specific treatment. Leads such as oxidative stress, defects in the intracellular regulation and the developing field of proteomics should be explored.

show abstract

Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trial

Cited by 284 publications

References 24 publications

Should ICSI be recommended routinely in patients with four or fewer oocytes retrieved?

Should ICSI be recommended routinely in patients with four or fewer oocytes retrieved?

The role of hyaluronic acid binding assay in choosing the fertilization method for patients undergoing IVF for unexplained infertility

Comments on the release of the 5th edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen

Contact Info

Product

Resources

About