Conventional clinicopathologic prognostic factors in surgically resected nonsmall cell lung carcinoma

Suzuki, Kenji; Nagai, Kanji; Yoshida, Junji; Nishimura, Mitsuyo; Takahashi, Kenro; Yokose, Tomoyuki; Nishiwaki, Yutaka

doi:10.1002/(sici)1097-0142(19991115)86:10<1976::aid-cncr14>3.0.co;2-i

Cited by 125 publications

(39 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patient characteristics such as gender, age and 5-year OS were similar in the present study to those of previous reports (11). Moreover, the results of univariate and multivariate analysis regarding the prognostic significance of clinicopathological factors, such as lymph node metastasis and stage of disease, were also in accordance with previous studies.…”

Section: Discussionsupporting

confidence: 91%

Prognostic significance of heat shock protein 105 in lung adenocarcinoma

Oda

Morii²,

Inoue³

et al. 2009

Mol Med Rep

View full text Add to dashboard Cite

Abstract. Heat shock protein 105 (HSP105) is overexpressed in various tumors and is known to protect cells from cytotoxic stimuli. The prognostic significance of HSP105 expression in cancer has not been fully evaluated. Here, HSP105 expression in lung adenocarcinoma was immunohistochemically examined in 116 patients: 68 males and 48 females with ages ranging from 38-81 (median 63) years. Tumor stage was I in 64, II in 16 and III in 36 patients. In non-cancerous tissues, HSP105 was expressed in the ciliated cells of bronchi. Tumor cells were constantly positive for HSP105, with varying intensities. The HSP105 score in each case was determined based on the staining intensity of the tumor cells occupying the widest area of cancerous tissue as follows: cases with tumor cells showing an intensity weaker than, comparable to and stronger than the bronchial epithelium were assigned a score of 1, 2 and 3, and numbered 84, 19 and 13 cases, respectively. HSP105 score was significantly correlated with the rate of recurrence and the stage of the disease. Univariate analysis showed that lymph node metastasis, disease stage and HSP105 score were unfavorable prognostic factors. Multivariate analysis revealed that lymph node metastasis and HSP105 score were independent prognostic factors for overall and disease-free survival. HSP105 expression is useful for the prediction of prognosis in patients with lung adenocarcinoma.

show abstract

Section: Discussionsupporting

confidence: 91%

Prognostic significance of heat shock protein 105 in lung adenocarcinoma

Oda

Morii²,

Inoue³

et al. 2009

Mol Med Rep

View full text Add to dashboard Cite

show abstract

“…37 In addition, the uni-and multivariate analyses showed the prognostic significance of clinicopathological factors, including tumor size and stage of disease, as reported previously. 37 These findings indicate that the results obtained from the present clinical cases are commonly applicable.…”

Section: Discussionsupporting

confidence: 72%

Tumorigenic Role of Orphan Nuclear Receptor NR0B1 in Lung Adenocarcinoma

Oda

Tian

Inoue

et al. 2009

The American Journal of Pathology

View full text Add to dashboard Cite

Cancer stem cells are a limited population of tumor cells that are thought to reconstitute whole tumors. The Hoechst dye exclusion assay revealed that tumors are composed of both a main population and a side population of cells, which are rich in cancer stem cells. NR0B1 is an orphan nuclear receptor that is expressed to a greater extent in the side population, as compared with the main population, of a lung adenocarcinoma cell line. In this study, we investigated the role of NR0B1 in lung adenocarcinoma cells. Reduction of NR0B1expression levels in lung adenocarcinoma cell lines resulted in vulnerability to anticancer drugs and decreased abilities for invasion, in vitro colony formation, and tumorigenicity in nonobese diabetic/severe compromised immunodeficient mice. When 193 cases of lung adenocarcinoma were immunohistochemically examined, higher levels of NR0B1 expression correlated with higher rates of lymph node metastasis and recurrence. Multivariate analysis revealed high NR0B1 expression levels, stage of the disease, and size of tumor to be independent unfavorable prognostic factors for overall and disease-free survival rates. In clinical samples, NR0B1 expression levels inversely correlated to the proportion of methylated CpG sequences around the transcription initiation site of the NR0B1 gene, suggesting the epigenetic control of NR0B1 transcription in lung adenocarcinoma. In conclusion, NR0B1 might play a role in the malignant potential of lung adenocarcinoma. (Am J

show abstract

“…1 Lymph node metastasis specifically is recognized as an important prognostic factor. 2 Lymphatic invasion and blood vessel invasion are additional indicators of disease recurrence or poor overall survival. 3,4 However, the mechanism of lymphatic spread remains unclear.…”

mentioning

confidence: 99%

Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma

Arinaga

Noguchi

Takeno

et al. 2003

Cancer

141

103

View full text Add to dashboard Cite

A temperature‐sensitive polymer, poly(N‐isopropylacrylamide) [poly(NIPAM)], was tested to flocculate kaolinite clay suspensions. Settling tests at both room temperature and 40°C were carried out. The results show that settling at 40°C resulted in significantly higher settling rates and smaller sediment volumes. This behavior indicates that the polymer molecules changed from a stretched structure to a coil‐like conformation with increasing temperature. It is the change in conformation that induced more compacted flocs, thus resulting in faster settling. To understand the role of temperature in the flocculation, the long‐range interaction and adhesion forces between kaolinite clay particles in the polymer solutions at both room temperature and 40°C were measured using an atomic force microscope (AFM). The measured adhesion forces correlated well with the settling characteristics: a stronger adhesion led to a higher initial settling rate. The retraction force profiles obtained at different temperatures confirmed the conformational change of the polymer with temperature. © 2006 American Institute of Chemical Engineers AIChE J, 2007.

show abstract

Conventional clinicopathologic prognostic factors in surgically resected nonsmall cell lung carcinoma

Cited by 125 publications

References 55 publications

Prognostic significance of heat shock protein 105 in lung adenocarcinoma

Prognostic significance of heat shock protein 105 in lung adenocarcinoma

Tumorigenic Role of Orphan Nuclear Receptor NR0B1 in Lung Adenocarcinoma

Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma

Contact Info

Product

Resources

About