Conventional and Microwave Synthesis and Antioxidant Evaluation of Benzothiazole Substituted 4-Thiazolidinones

Shetty, Chaithra R.; Bhat, Ishwar K.; Kumar, Abhishek; Merugumolu, Vijay Kumar; Bc, Revanasidappa; Gatphoh, Banylla Felicity Dkhar

doi:10.53879/id.57.10.12175

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Besides the previously described antioxidant properties of Compound 10d (Figures 5 and 17), this derivative demonstrated dose dependent anticancer activity against Ehrlich ascites carcinoma (EAC) induced peritoneal ascites in mice. The outcomes were comparable to standard 5-fluorouracil [23].…”

mentioning

confidence: 77%

“…Other derivatives showed less antioxidant activity than standard ascorbic acid (IC50 values of 22.88 µg/mL for DPPH assay and 12.61 µg/mL for NO test). Shetty et al synthesized thiazolidin-4-one-benzothiazole hybrids (10a-10f) and conducted their evaluation for antioxidant activity (Figure 5) [23]. For evaluation of antioxidant activity three different models (DPPH, nitric oxide and superoxide anion radical scavenging assays) were used.…”

Section: Biological Activities Of Thiazolidin-4-ones 21 Antioxidant Activitymentioning

confidence: 99%

“…The compound PPIT inhibited MAO-A isoform in none of the tested concentrations. Shetty et al synthesized thiazolidin-4-one-benzothiazole hybrids (10a-10f) and conducted their evaluation for antioxidant activity (Figure 5) [23]. For evaluation of antioxidant activity three different models (DPPH, nitric oxide and superoxide anion radical scavenging assays) were used.…”

Section: Biological Activities Of Thiazolidin-4-ones 21 Antioxidant Activitymentioning

confidence: 99%

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The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies

Mech

Kurowska

Trotsko

2021

IJMS

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Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a privileged scaffold in medicinal chemistry. This review is focused on the latest scientific reports regarding biological activities of thiazolidin-4-ones published in 2020 and 2021. The review covers recent information about antioxidant, anticancer, anti-inflammatory, analgesic, anticonvulsant, antidiabetic, antiparasitic, antimicrobial, antitubercular and antiviral properties of thiazolidin-4-ones. Additionally, the influence of different substituents in molecules on their biological activity was discussed in this paper. Thus, this study may help to optimize the structure of thiazolidin-4-one derivatives as more efficient drug agents. Presented information may be used as a practical hint for rational design of new small molecules with biological activity, especially among thiazolidin-4-ones.

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confidence: 77%

Section: Biological Activities Of Thiazolidin-4-ones 21 Antioxidant Activitymentioning

confidence: 99%

Section: Biological Activities Of Thiazolidin-4-ones 21 Antioxidant Activitymentioning

confidence: 99%

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The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies

Mech

Kurowska

Trotsko

2021

IJMS

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Boosting the antimicrobial performance based on new fused spirothiazolidine framework analogs

et al. 2022

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New spiro[cyclohexane-1,2'-thiazolo[4,5-b]pyridine derivatives (3–23) were investigated. Then there is in vitro antimicrobial potency against possible organisms Staphylococcus aurous ATCC-47,077, Bacillus cereus ATCC-12228, Escherichia coli ATCC-25922, Salmonella typhiATCC-15566, and Candida albicans ATCC-10231 were tested utilizing commercially available antibiotics ampicillin as a reference drug. A preliminary antimicrobial test represented that derivatives: (Aldoses) 3'-(4-fluorophenyl)-5'-(methyleneamino)-7'-(p-tolyl)-3'H-spiro[cyclohexane-1,2'-thiazolo[4,5-b]pyridine]-6'-carbonitrile (16–19) and (Acetyl aldoses) 3'-(4-fluorophenyl)-5'-(methyleneamino)-7'-(p-tolyl)-3'H-spiro [cyclohexane-1,2'-thiazolo[4,5-b]pyridine]-6'-carbonitrile (20–23) exhibited higher antifungal, and antibacterial performance with minimum inhibitory concentrations values of (39–67 µg/ml) toward all pathogenic strains compared to common reference drug ampicillin.

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Catalyzed syntheses of novel series of spiro thiazolidinone derivatives with nano Fe2O3: spectroscopic, X-ray, Hirshfeld surface, DFT, biological and docking evaluations

Abbass,

El-Rayyes,

Khalil Ali

et al. 2024

Sci Rep

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Twelve spiro thiazolidinone compounds ( A–L ) were synthesized via either conventional thermal or ultrasonication techniques using Fe 2 O 3 nanoparticles. The modification of the traditional procedure by using Fe 2 O 3 nanoparticles led to enhancement of the yield of the desired candidates to 78–93% in approximately half reaction time compared with 58–79% without catalyst. The products were fully characterized using different analytical and spectroscopic techniques. The structure of the two derivatives 4-phenyl-1-thia-4-azaspirodecan-3-one ( A ) and 4-(p-tolyl)-1-thia-4-azaspirodecan-3-one ( B ) were also determined using single crystal X-ray diffraction and Hirshfeld surface analysis. The two compounds ( A and B ) were crystallized in the orthorhombic system with Pbca and P2 1 2 1 2 1 space groups, respectively. In addition, the crystal packing of compounds revealed the formation of supramolecular array with a net of intermolecular hydrogen bonding interactions. The energy optimized geometries of some selected derivatives were performed by density functional theory (DFT/B3LYP). The reactivity descriptors were also calculated and correlated with their biological properties. All the reported compounds were screened for antimicrobial inhibitions. The two derivatives, F and J , exhibited the highest levels of bacterial inhibition with an inhibition zone of 10–17 mm. Also, the two derivatives, F and J , displayed the most potent fungal inhibition with an inhibition zone of 15–23 mm. Molecular docking investigations of some selected derivatives were performed using a B-DNA (PDB: 1BNA) as a macromolecular target. Structure and activity relationship of the reported compounds were correlated with the data of antimicrobial activities and the computed reactivity parameters.

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Conventional and Microwave Synthesis and Antioxidant Evaluation of Benzothiazole Substituted 4-Thiazolidinones

Cited by 3 publications

References 10 publications

The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies

The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies

Boosting the antimicrobial performance based on new fused spirothiazolidine framework analogs

Catalyzed syntheses of novel series of spiro thiazolidinone derivatives with nano Fe2O3: spectroscopic, X-ray, Hirshfeld surface, DFT, biological and docking evaluations

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