Convenient Synthesis of 7,8‐Dimethoxytetralin‐2‐one.

Gorka, Álmos; Czuczai, B.; Szoleczky, P.; Hazai, László; Háda, Viktor; Szantay, Cs.

doi:10.1002/chin.200604090

Cited by 2 publications

(3 citation statements)

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“…Supervisor: László Hazai e-mail: lhazai@mail.bme.hu 2-Tetralones containing hydroxy and/or methoxy substituent(s) on the aromatic ring are known as important sources of synthetic precursors of a wide range of compounds, including steroids, heterocycles and pharmaceuticals [9]. The synthesis of 7,8-dimethoxytetralin-2-one (1) is described in the literature [2], most of the elaborated methods, however, use starting materials and reagents [3][4][5] that are not easily accessible and inconvenient, respectively.…”

Section: New Synthesis Of 78-dimethoxy-tetralin-2-one áLmos Gorka Dementioning

confidence: 99%

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Abstracts of PhD conference 2006

László¹

2007

Per. Pol. Chem. Eng.

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Sn was added to a 1% Rh/Al 2 O 3 catalyst (D=75%) by controlled surface reaction (CSR) [1, 2] of Sn(n-C 4 H 9) 4 in amounts corresponding nominally to 1/4, 1/2, 1 and 2 monolayers. The Sn-Rh catalysts were characterized by hydrogen chemisorption, TEM, CO-FTIR, Mössbauer spectroscopy [3] and in test reaction of methylcyclopentane (MCP) [4]. Three different Sn phases were found after reduction (Table): SnO 2 , Sn-rich and Sn-poor RhSn alloy [5]. Tin transformed entirely to SnO 2 upon oxidation. The effect of oxidation (373 K) and reduction (at 473 K) appeared to be reversible. The 1 monolayer Sn-Rh sample behaved in MCP transformation similarly to a catalyst with small Rh ensembles while the product pattern of other Sn-Rh catalysts was similar to that produced by larger Rh ensembles (Table). The suggested model is as follows: Sn was deposited selectively on low-Miller-index microfacets of Rh when its introduced amount was lower than 1 monolayer. Increasing the introduced amount of Sn led to its deposition also on high-Millerindex sites (random deposition).

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Section: New Synthesis Of 78-dimethoxy-tetralin-2-one áLmos Gorka Dementioning

confidence: 99%

“…In my lecture I report an efficient methodology to synthesize the title compound (1) using simple reaction steps, commercially available starting materials and reagents [9]. Most of the reaction steps were carried out in 10-30 g quantities.…”

Section: New Synthesis Of 78-dimethoxy-tetralin-2-one áLmos Gorka Dementioning

confidence: 99%

Abstracts of PhD conference 2006

László¹

2007

Per. Pol. Chem. Eng.

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“…The compound 2, has recently been synthesised 2 as an intermediate in the preparation of biologically active of compounds. Compounds 3 and 4 are potential intermediates for the synthesis of morphine 3 and quinone lomandrone 4,5 respectively.…”

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confidence: 99%