Since the end of 2019, we have been combating the health challenges caused by the multiple waves of COVID-19 (coronavirus disease 2019) pandemic caused by the mutated variants of concern of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The key to successfully combating the COVID-19 pandemic remains prevention by vaccination, rapid as well as timely detection and diagnosis, with proper treatment of infection cases. The previously used and standardized viral diagnostics and therapeutics have not been effective in combating the SARS-CoV-2 virus as observed during this ongoing COVID-19 pandemic. Nanotechnology and it's applications in nanomedicine have been very effective and valuable as applied in drug delivery, vaccines and nanosensor technology in various diseases. In the last three years, nanotechnology, nanoparticles and nanomedicine have played a very significant role in the prevention, diagnostics, treatment options and vaccination associated with the COVID-19 infection. In this concise review, the most recent developments on the role played by nanotechnology, nanoparticles and nanomedicine in the diagnostics, vaccination and treatment options for COVID-19 have been highlighted. .