Convenient Approaches to the Synthesis of Oligonucleotide Macrocycles Containing Non-nucleotide Linkers

Ефимов, В. А.; Buryakova, A. A.; Kalinkina, A. L.; Choob, M. V.; Chakhmakhcheva, O. G.; Ojwang, Joshua O.; Rando, Robert F.

doi:10.1080/07328319808005185

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Linear Solid Supports For 3 -Carboxyalkylation1

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“…Thus, oligonucleotides assembled on a solid support 90 (Fig. 3.1.10) were released with 0.2 M NaOH in 60% aqueous dioxane for 15 min at room temperature (Chakhmakhcheva et al, 1997;Efimov et al, 1998). Under anhydrous conditions, the release was performed using 0.5 M DBU in THF for 2 hr.…”

Section: Linear Solid Supports For 3 -Carboxyalkylationmentioning

confidence: 99%

Solid‐Phase Supports for Oligonucleotide Synthesis

Guzaev¹

2013

CP Nucleic Acid Chemistry

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This unit attempts to provide a reasonably complete inventory of over 280 solid supports available to oligonucleotide chemists for preparation of natural and 3'-modified oligonucleotides. Emphasis is placed on non-nucleosidic solid supports. The relationship between the structural features of linkers and their behavior in oligonucleotide synthesis and deprotection is discussed wherever the relevant observations are available.

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Section: Linear Solid Supports For 3 -Carboxyalkylationmentioning

confidence: 99%