Convenient approach to synthesize tertiary α-hydroxy cyclic phosphonates catalyzed by potassium carbonate under solvent-free conditions

Abstract

A new environmentally benign, convenient, and easy method for the synthesis of tertiary α-hydroxy cyclic phosphonates was developed. In the presence of potassium carbonate, aromatic/heteroaromatic ketones and base-sensitive ketones can react with phosphite to form tertiary α-hydroxyphosphonates under solvent-free and mild conditions.