Convenient approach for the synthesis of ONO-LB-457, a potent leukotriene B4 receptor antagonist

Hamri, Salha; Jouha, Jabrane; Oumessaoud, Asmaa; Pujol, Maria Dolors; Khouili, Mostafà; Guillaumet, Gérald

doi:10.1016/j.tet.2020.131740

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…etc.). QPSs were obtained using this method from triphenylphosphine for n = 1 [39,40], 2 , 3 [39,40,45,47,[60][61][62][63][64][65][66][67][68][69][70], 4 [40,44,47,62,65,[71][72][73][74][75][76][77][78][79][80][81][82][83][84], 5 [45,55,61,62,65,67,[85][86][87][88][89][90][91][92][93][94]…”

Section: Introductionmentioning

confidence: 99%

Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties

et al. 2021

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It has been shown for a wide range of epoxy compounds that their interaction with triphenylphosphonium triflate occurs with a high chemoselectivity and leads to the formation of (2-hydroxypropyl)triphenylphosphonium triflates 3 substituted in the 3-position with an alkoxy, alkylcarboxyl group, or halogen, which were isolated in a high yield. Using the methodology for the disclosure of epichlorohydrin with alcohols in the presence of boron trifluoride etherate, followed by the substitution of iodine for chlorine and treatment with triphenylphosphine, 2-hydroxypropyltriphenylphosphonium iodides 4 were also obtained. The molecular and supramolecular structure of the obtained phosphonium salts was established, and their high antitumor activity was revealed in relation to duodenal adenocarcinoma. The formation of liposomal systems based on phosphonium salt 3 and L-α-phosphatidylcholine (PC) was employed for improving the bioavailability and reducing the toxicity. They were produced by the thin film rehydration method and exhibited cytotoxic properties. This rational design of phosphonium salts 3 and 4 has promising potential of new vectors for targeted delivery into mitochondria of tumor cells.

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Section: Introductionmentioning

confidence: 99%

Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties

et al. 2021

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New and promising type of leukotriene B4 (LTB4) antagonists based on the 1,4-benzodioxine structure

Bouissane

Khouili

Coudert

et al. 2023

European Journal of Medicinal Chemistry

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Pathogenesis of allergic diseases and implications for therapeutic interventions

Wang

Zhou

Zhang

et al. 2023

Sig Transduct Target Ther

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Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD), food allergy (FA), and eczema are systemic diseases caused by an impaired immune system. Accompanied by high recurrence rates, the steadily rising incidence rates of these diseases are attracting increasing attention. The pathogenesis of allergic diseases is complex and involves many factors, including maternal-fetal environment, living environment, genetics, epigenetics, and the body’s immune status. The pathogenesis of allergic diseases exhibits a marked heterogeneity, with phenotype and endotype defining visible features and associated molecular mechanisms, respectively. With the rapid development of immunology, molecular biology, and biotechnology, many new biological drugs have been designed for the treatment of allergic diseases, including anti-immunoglobulin E (IgE), anti-interleukin (IL)-5, and anti-thymic stromal lymphopoietin (TSLP)/IL-4, to control symptoms. For doctors and scientists, it is becoming more and more important to understand the influencing factors, pathogenesis, and treatment progress of allergic diseases. This review aimed to assess the epidemiology, pathogenesis, and therapeutic interventions of allergic diseases, including AR, AAS, AD, and FA. We hope to help doctors and scientists understand allergic diseases systematically.

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Convenient approach for the synthesis of ONO-LB-457, a potent leukotriene B4 receptor antagonist

Cited by 3 publications

References 38 publications

Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties

Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties

New and promising type of leukotriene B4 (LTB4) antagonists based on the 1,4-benzodioxine structure

Pathogenesis of allergic diseases and implications for therapeutic interventions

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