Convenient and green synthesis of novel 1,2,5-trisubstituted benzimidazole compounds and their antibacterial activity evaluation

Liu, Kejun; Luo, Rui; Fu, Jiaxu; Bao, Lijian; Xue, Yafei; Gu, Qiang; Lin, Feng

doi:10.1007/s13738-022-02736-z

Cited by 2 publications

(2 citation statements)

References 44 publications

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“…Antibacterial Activity Assays: According to the literature, [53,54] Mycobacteria smegmatis MC 2 155 strain was selected as model organisms for the determination of the minimum inhibitory concentrations (MICs) of the synthesized compounds 1,4-bis((3arylisoxazol-5-yl)methyl)piperazines (6a-6l). The MIC was determined by the microdilution method.…”

Section: Discussionmentioning

confidence: 99%

Effective Synthesis and Anti‐Mycobacterial Activity of Isoxazole‐Substituted Piperazine Derivatives

Chen

Xue

et al. 2023

ChemistrySelect

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A series of piperazine derivatives containing bis‐isoxazole were successfully synthesized by the reaction between piperazine and substituted isoxazole derivatives under the optimal reaction condition. The structures of all products were confirmed by IR, HRMS, 1H and 13C NMR. The antibacterial activities of all products against Mycobacteria smegmatis in vitro were tested using rifampin as a positive control. Two compounds presented wonderful anti‐mycobacterium activity, and their minimum inhibitory concentrations were respectively 2.60±1.11 μmol/mL and 4.35±0.00 μmol/mL, which indicated that they can be regarded as candidates for development of anti‐TB drugs.

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Section: Discussionmentioning

confidence: 99%

Effective Synthesis and Anti‐Mycobacterial Activity of Isoxazole‐Substituted Piperazine Derivatives

Chen

Xue

et al. 2023

ChemistrySelect

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“…According to the literature, [33,34] Mycobacteria smegmatis MC 2 155 strain was selected as model organisms for the determination of the minimum inhibitory concentrations (MICs) of the synthesized 3-methyl-4-(hetero) arylmethylene isoxazole-5(4H)-ones. Through measuring the growth of Mycobacteria smegmatis MC 2 155 at different concentrations of synthesized compounds, the MIC values of these 16 compounds were obtained by using rifampicin as a reference.…”

Section: Antibacterial Activity Assaysmentioning

confidence: 99%

Na₂S₂O₃ Catalyzed Three‐Component Synthesis and Anti‐Bacterial Activity of 3‐Methyl‐4‐(hetero)arylmethylene isoxazole‐5(4H)‐ones

Bi,

Wang,

Bian

et al. 2024

Chemistry & Biodiversity

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An efficient and green method for synthesizing 3‐methyl‐4‐(hetero)arylmethylene isoxazole‐5(4H)‐ones was developed using a recyclable and environmental‐friendly catalyst, Na2S2O3, and 16 target compounds were successfully synthesized under the obtained optimal reaction condition. Using rifampicin as a positive control, the antibacterial activity of all synthesized compounds was tested by micro dilution method, among them, 3‐methyl‐4‐ [(2,4‐dimethoxyphenyl) methylene] ‐ isoxazole‐5‐one (4m) presented wonderful antimicrobial activity, which may contribute to the development of anti‐tuberculosis drugs.

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Convenient and green synthesis of novel 1,2,5-trisubstituted benzimidazole compounds and their antibacterial activity evaluation

Cited by 2 publications

References 44 publications

Effective Synthesis and Anti‐Mycobacterial Activity of Isoxazole‐Substituted Piperazine Derivatives

Effective Synthesis and Anti‐Mycobacterial Activity of Isoxazole‐Substituted Piperazine Derivatives

Na₂S₂O₃ Catalyzed Three‐Component Synthesis and Anti‐Bacterial Activity of 3‐Methyl‐4‐(hetero)arylmethylene isoxazole‐5(4H)‐ones

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Convenient and green synthesis of novel 1,2,5-trisubstituted benzimidazole compounds and their antibacterial activity evaluation

Cited by 2 publications

References 44 publications

Effective Synthesis and Anti‐Mycobacterial Activity of Isoxazole‐Substituted Piperazine Derivatives

Effective Synthesis and Anti‐Mycobacterial Activity of Isoxazole‐Substituted Piperazine Derivatives

Na2S2O3 Catalyzed Three‐Component Synthesis and Anti‐Bacterial Activity of 3‐Methyl‐4‐(hetero)arylmethylene isoxazole‐5(4H)‐ones

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Na₂S₂O₃ Catalyzed Three‐Component Synthesis and Anti‐Bacterial Activity of 3‐Methyl‐4‐(hetero)arylmethylene isoxazole‐5(4H)‐ones