Controversies surrounding current therapies for sepsis syndrome

Cavaillon, Jean‐Marc

doi:10.1016/0020-2452(96)81482-5

Cited by 9 publications

(6 citation statements)

References 147 publications

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“…Eicosapentaenoic acid -enriched phospholipids extracted from sea cucumber Cucumaria frondosa, also has an inhibition effect on the reactive oxygenated species [89,[98][99][100][101][102][103][104][105]. Wu et al [89] remarks that this antioxidant compound alters the metabolic way of the mitochondrial apoptosis [89].…”

Section: Therapy With Antioxidantsmentioning

confidence: 99%

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Bedreag¹,

Rogobete

Sărăndan³

et al. 2015

Anaesthesiol Intensive Ther

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Multiple trauma patients require extremely good management and thus, the trauma team needs to be prepared and to be up to date with the new standards of intensive therapy. Oxidative stress and free radicals represent an extremely aggressive factor to cells, having a direct consequence upon the severity of lung inflammation. Pulmonary tissue is damaged by oxidative stress, leading to biosynthesis of mediators that exacerbate inflammation modulators. The subsequent inflammation spreads throughout the body, leading most of the time to multiple organ dysfunction and death. In this paper, we briefly present an update of biochemical effects of oxidative stress and free radical damage to the pulmonary tissue in patients in critical condition in the intensive care unit. Also, we would like to present a series of active substances that substantially reduce the aggressiveness of free radicals, increasing the chances of survival.

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Section: Therapy With Antioxidantsmentioning

confidence: 99%

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Bedreag¹,

Rogobete

Sărăndan³

et al. 2015

Anaesthesiol Intensive Ther

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“…A closer friendship and collaboration were established between Pasteur and Jacobsen [39] and their laboratories, which initiated “the revanche project” [40, 41] aiming to make better beer than the German's. Pasteur's only son Jean Baptiste was enrolled in the French‐German war in 1870–1871 and injured, and when the Germans prevailed the French army at Sedan and besieged Paris, why the citizens in Paris ousted the government, it had to escape from the city in balloons.…”

Section: The Studies On Beer Production and Its Impact On Success Of ...mentioning

confidence: 99%

“…1, 6, 9, and 10). We thank her also for the gifts of Bruno Latour book from 1994—“Pasteur – une science, un style, un siècle.” My acknowledgement goes also to a third Pasteurian, Jean‐Marc Cavaillon (jean-marc.cavaillon@pasteur.fr), author to a recent review on Pasteur [12] for multiple communications and advices, and for access to his PowerPoint presentation [40]. Finally, my earlier supervisor emeritus docent Thorkild C. Bøg‐Hansen from University of Copenhagen is acknowledged for his comments and proposals to the final article.…”

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confidence: 99%

Louis Pasteur—The life of a controversial scientist with a prepared mind, driven by curiosity, motivation, and competition

Brogren¹

2023

APMIS

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Louis Pasteur, born December 27, 1822 in Dole, France, showed in his childhood and youth great abilities as an artistic painter; however by an age of 19, his interest changed toward science, and he moved to Paris to study chemistry and physics at École Normale Supérieure. During graduation, he initiated research on chiral crystallography and stereochemistry and got his doctorates in 1847 in both chemistry and physics. In 1848, he started as high school teacher in Dijon, but shortly after he became a deputy professor at the University of Strasbourg in chemistry and got married to the rector's daughter Marie Laurent. They had five children, of which only two survived. The family moved to Lille in 1854, where he worked as professor in chemistry and became the dean at the new Faculty of Science at the University of Lille. He initiated his famous research on fermentation in 1855. Louis Pasteur moved back to École Normale Supérieure in 1857, where a major part of his innovative research on fermentation took place ending up with the development of pasteurization in 1864. Through genius experiments, he disputed the spontaneous genesis theory and founded the basis for the germ theory, later confirmed by his enemy Robert Koch and several other research teams, which he for lifetime competed with on the cure and prevention against infectious disease causes by both bacteria such as cholera, anthrax, and virus‐induced infections as yellow fever and rabies. However, most of his experiments were done on animals since Pasteur and his colleagues at École Normale Superiére were not physicians but scientists. The first successful attenuated vaccine used in humans against rabies was, when the 9‐year‐old Joseph Meister was cured or prevented from rabies in 1885 after 13 vaccine injections done by the young pediatrician Joseph Grancher. This worldwide known intervention is both world famous and ethically criticized and disputed. The Pasteur Institute was inaugurated in 1888—now an international prestigious research institute—which has been expanded since in a network of affiliated Pasteur institutes over the whole world. There were multiple links to Danish scientists of the 19th century and to the Danish brewery industry. Most well known is the strong friendship between Louis Pasteur and the Carlsberg brewery and especially to its founder Jacob Christian Jacobsen, who was a great believer on a scientific approach to a cleaner fermentation process and better beer quality. Louis Pasteur stands as a milestone example of the fruitful outcome of scientific competition and collaboration and should therefore be remembered as an inspiration for present and future scientists.

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“…These risks and limitations could theoretically be overcome with MAbs of human origin (156), but despite intense efforts (12,20,43,60), human MAbs from hybridomas and lymphocyte cell lines have proven too difficult to generate easily. Finally and perhaps most importantly, the failures of clinical trials of the anti-LPS mouse IgM E5 MAb from Xoma (Berkeley, CA, USA) (completed between 1992 and 1993) and the human IgM HA-1A from Stanford/Centocor (Leiden, The Netherlands) for septic shock (27) combined to dampen interest in MAbs as therapeutic drugs.…”

Section: Introductionmentioning

confidence: 99%

Antibody Engineering at the Millennium

2000

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It has been almost 100 years since von Behring and Kitasato received the first Nobel prize for the discovery of passive immunotherapy and nearly 25 years since Köhler and Milstein first reported hybridoma technology. In the 15 years since Mullis and co-workers described PCR, a number of discoveries and technologies have converged to produce a renaissance in antibody therapeutics. Our vision of antibodies as tools for research--useful for the prevention, detection and treatment of disease--has been revolutionized by these recent advances. This review specifically focuses on what is now called antibody engineering and includes chimeric and humanized antibodies, immunoglobulin fragments, antibody libraries, antibody fusion proteins and transgenic organisms as bioreactors. As a consequence of refinements in antibody technology, the field of genetically engineered immunoglobulins has matured into an elegant and important drug and reagent development platform.

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Controversies surrounding current therapies for sepsis syndrome

Cited by 9 publications

References 147 publications

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Louis Pasteur—The life of a controversial scientist with a prepared mind, driven by curiosity, motivation, and competition

Antibody Engineering at the Millennium

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