Controversies in Acral Lentiginous Melanoma

Stalkup, Jennifer R.; Orengo, Ida; Katta, Rajani

doi:10.1097/00042728-200211000-00015

Cited by 14 publications

(34 citation statements)

References 66 publications

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“…Concerning the epidemiological data, ALM occurred in older people according to all previously reported studies [4,5,[17][18][19] and no difference in sex distribution was found with an equal preponderance of females to males like in our overall melanoma population [13]. Although some conflicting results have been found in the literature, a slight female preponderance has more often been published but in populations where men predominate [4,5,17].…”

Section: Discussionmentioning

confidence: 45%

“…Acral lentiginous melanoma (ALM) is a distinct subtype of melanoma that characteristically occurs on the palms, soles, or beneath the nail plate [2][3][4]. The pathogenesis remains unknown but, mainly due to the anatomical location on weight-bearing areas, trauma involvement has been suggested, and previous trauma has been reported to vary from 13 to 55% [5][6][7].…”

mentioning

confidence: 99%

“…The role of previous melanocytic precursors has been evaluated with non-conclusive results, although this subtype occurs within nevus remnants at a lower rate than the other subtypes [5,6]. Besides, ALM appears to be unrelated to sun exposure-patient phenotype interaction, since it is the predominant subtype in darkskinned populations albeit with the same incidence as in white-skinned populations [2,4,7]. Additionally, a distinct genetic profile has been recently demonstrated [9][10][11][12].…”

mentioning

confidence: 99%

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Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility

Nagore

Pereda

Botella‐Estrada

et al. 2008

Cancer Causes Control

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Our results, from a clinical and epidemiological point of view, support recent data on genetic characterization of melanomas. In comparison with the other frequent variants we have shown that ALM has some important differences which emphasize that it is a distinct entity more probably related to certain cancer susceptibility but unrelated to familial melanoma, tendency to developing nevus or sun exposure.

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Section: Discussionmentioning

confidence: 45%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility

Nagore

Pereda

Botella‐Estrada

et al. 2008

Cancer Causes Control

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show abstract

“…In many melanomas, the intra-dermal component is atypical, but cases in which the intra-dermal component in melanoma is nevoid can occur [137]. We have seen a few cases in which the intra-dermal component of melanoma was barely distinguishable from a nevus.…”

Section: Acral Nevi Vs Acral Melanomamentioning

confidence: 72%

Melanocytic nevi simulant of melanoma with medicolegal relevance

Massi

2007

Virchows Arch

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A group of melanocytic benign nevi are prone to be misdiagnosed as nodular or superficial spreading melanoma. This review illustrates the most frequent forms of these nevi in direct comparison with their malignant morphologic counterparts. The nevi are: hyper-cellular form of common nevus to be distinguished from nevoid melanoma, Spitz nevus (vs spitzoid melanoma), Reed nevus (vs melanoma with features of Reed nevus), cellular atypical blue nevus (vs melanoma on blue nevus), acral nevus (vs acral melanoma), Clark dysplastic nevus (vs superficial spreading melanoma), desmoplastic nevi (vs desmoplastic melanoma), benign proliferative nodules in congenital nevi (vs melanoma on congenital nevi), epithelioid blue nevus (vs animal type melanoma) and regressed nevus (vs regressed melanoma). For each single 'pair' of morphological look-alikes, a specific set of morphological, immunohistochemical and genetic criteria is provided.

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“…Am sensitivsten in der Paraffinhistologie gelten Anti-Protein-S100-Antikörper (95%), gefolgt von Anti-HMB45-Antikörpern (80%) und Anti-Mart1/Melan-A-Antikör-pern (79%; [26,31]). …”

Section: Introductionunclassified

Operative Therapie von akral lokalisierten Melanomen

Möhrle¹,

Lichte²,

Breuninger³

2011

Hautarzt

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Acral lentiginous melanomas (ALM) represent 4-10% of cutaneous melanomas in white populations. Patients with ALM seem to have a poor prognosis, often due to late diagnosis. Micrographic surgery (3D-histology) is not seen as surgical procedure but more as histopathological technique. With micrographic surgery, continuously spreading ALM can be excised with smaller excision margins and good functional and cosmetic outcomes. In a recent study, 244 patients with ALM were compared using conventional histology versus 3D-histology. Clinical and surgical risk factors influence the prognosis of ALM. Tumor thickness and ulceration are the most important prognostic factors. 3D-histology with paraffin technique (optionally combined with immunohistological methods) can reduce excision margins and avoid local recurrences. Subungual melanomas represent only 2-3% of cutaneous melanomas in Caucasian and 20% in African or Asian skin type and are often clinically misdiagnosed. They are often localized on the thumb or great toe, which are most important for the function of the affected limb. The excision of subungual melanoma with 3D-histology and tumor-free excision margins including the nail matrix can be seen as a safe surgical strategy, which does not hazard the prognosis of the patient. Function and cosmesis of the finger or toe are preserved. Amputation in subungual melanoma is not recommended and should be reserved only for infiltrating melanomas with affection of the bone or joint.

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Controversies in Acral Lentiginous Melanoma

Cited by 14 publications

References 66 publications

Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility

Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility

Melanocytic nevi simulant of melanoma with medicolegal relevance

Operative Therapie von akral lokalisierten Melanomen

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