Controlling wettability of PECVD-deposited dual organosilicon/carboxylic acid films to influence DNA hybridisation assay efficiency

Flynn, Shauna P.; Monaghan, Ruairi; Bogan, J.; McKenna, Milena; Cowley, Aidan; Daniels, Stephen; Hughes, G.; Kelleher, Susan M.

doi:10.1039/c7tb01925d

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…Samples were placed in the diffusion region of the plasma 150 mm from the electrode base. XPS analysis was carried out using a VG Microtech electron spectrometer at a base pressure of 5×10 −10 mbar, following the methods described in our previous work [37]. Film thickness calculations in the XPS were performed using the NIST EAL database programme version 1.3.…”

Section: Instrumentationmentioning

confidence: 99%

Nitrogen reactive ion etch processes for the selective removal of poly-(4-vinylpyridine) in block copolymer films

et al. 2018

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Self-assembling block copolymer (BCP) patterns are one of the main contenders for the fabrication of nanopattern templates in next generation lithography technology. Transforming these templates to hard mark materials is key for pattern transfer and in some cases, involves selectively removing one block from the nanopattern. For poly(styrene)-block-poly(4-vinylpyridine) (PS-b-P4VP), a high χ BCP system which could be potentially incorporated into semiconductor nanofabrication, this selective removal is predominantly done by a wet etch/activation process. Conversely, this process has numerous disadvantages including lack of control and high generation of waste leading to high cost. For these reasons, our motivation was to move away from the wet etch process and optimise a dry etch which would overcome the limitations associated with the activation process. The work presented herein shows the development of a selective plasma etch process for the removal of P4VP cores from PS-b-P4VP nanopatterned film. Results have shown that a nitrogen reactive ion etch plasma has a selectivity for P4VP of 2.2:1 and suggest that the position of the nitrogen in the aromatic ring of P4VP plays a key role in this selectivity. In situ plasma etching and x-ray photoelectron spectrometry measurements were made without breaking vacuum, confirming that the nitrogen plasma has selectivity for removal of P4VP over PS.

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Section: Instrumentationmentioning

confidence: 99%

Nitrogen reactive ion etch processes for the selective removal of poly-(4-vinylpyridine) in block copolymer films

et al. 2018

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“…There are many factors that affect hybridization such as surface coverage, ,− surface topography and chemistry, ,,− target concentration, , solvent status, ,− , spacer, − backfiller, − strand length, ,,, and DNA sequence. ,, Typically, the surface coverage plays a significant role in hybridization processes. It refers to the number of probe molecules immobilized on the microarray surface, which could directly impact the efficiency of the target-probe hybridization.…”

Section: Introductionmentioning

confidence: 99%

Correlated Hybrid DNA Structures Explored by the oxDNA Model

Qiao,

Ren

2023

Langmuir

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Thermodynamically, perfect DNA hybridization can be formed between probes and their corresponding targets due to the favorable energy. However, this is not the case dynamically. Here, we use molecular dynamics (MD) simulations based on the oxDNA model to investigate the process of DNA microarray hybridization. In general, correlated hybrid DNA structures are formed, including one probe associated with several targets as well as one target hybrid with multiple probes leading to the targetmediated hybridization. The formation of these two types of correlated structures largely depends on the surface coverage of the DNA microarray. Moreover, DNA sequence, DNA length, and spacer length have an impact on the structural formation. Our findings shed light on the dynamics of DNA hybridization, which is important for the application of DNA microarray.

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Interplay of electrostatic repulsion and surface grafting density on surface-mediated DNA hybridization

Traeger

Schwartz

2020

Journal of Colloid and Interface Science

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Controlling wettability of PECVD-deposited dual organosilicon/carboxylic acid films to influence DNA hybridisation assay efficiency

Abstract: Plasma oxidation of Zeonor and deposition of TEOS/AA thin film showing dual layer effect on the surface.

Cited by 3 publications

References 43 publications

Nitrogen reactive ion etch processes for the selective removal of poly-(4-vinylpyridine) in block copolymer films

Nitrogen reactive ion etch processes for the selective removal of poly-(4-vinylpyridine) in block copolymer films

Correlated Hybrid DNA Structures Explored by the oxDNA Model

Interplay of electrostatic repulsion and surface grafting density on surface-mediated DNA hybridization

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