This paper is the first part of a two-part paper, with the second part being [1], presenting a bottom-up description of electromagnetic chirality, which occurs in materials composed of particles with structural handedness 1. This part deals with the microscopic perspective of chirality. First, it highlights the three fundamental concepts related to chirality-mirror asymmetry, polarization rotation and magnetodielectric coupling-and points out the nontrivial interdependencies existing between them. Then, it lists a number of assumptions that pertain to the overall document. Next, it argues that metamaterials represent the most promising technology for chiral applications, and discusses their geometrical parameters, dipolar responses and electromagnetic polarizabilities. The following part compares two representative metaparticles that are complementarily related to chirality, namely the planar Omega particle and the twisted Omega, or helix, particle, shows that only the latter is mirrorasymmetric, and hence chiral, deduces from the mirror asymmetry criterion that chirality requires a voluminal geometry, and infers the magnetoelectric properties of the planar Omega and helix particles from their geometry. Finally, it recalls how to convert the microscopic dipole moments and polarizabilies into macroscopic polarization densities and susceptibilities to obtain a medium representation of a (meta)material structure. Upon this basis, the second part of the paper presents a macroscopic perspective of electromagnetic chirality and chiral materials.