Controlling the Size of Vesicles Prepared from Egg Lecithin using a Hydrotrope

Heldt, Nicole; Zhao, Jiawen; Friberg, Stig E.; Zhang, Z.; Slack, Gregory C.; Li, Y.

doi:10.1016/s0040-4020(00)00520-2

Cited by 21 publications

(19 citation statements)

References 10 publications

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“…Each of these techniques has its own unique advantages and, sometimes, limitations. For example, dyanamic light scattering can effectively measure particle size and particle size change in a surfactant system (13,14). However, the technique is not chemical specific.…”

Section: Figure 2 An Illustration Of a Micelle (In Polar Medium) Andmentioning

confidence: 99%

Dynamic NMR in an Advanced Laboratory

Odeh

2007

ACS Symposium Series

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In this experiment, undergraduate students of an advanced laboratory course are introduced to dynamic nuclear magnetic resonance spectrocopy (NMR). The students used pulsed-field gradient methods (PFG-NMR) to measure the diffusion coefficient (D) of components of micelle solutions containing solubilizates (alcohols) with varying alkyl chain length. From the data obtained, the partition coefficient (P) of the alcohols between the aqueous and micelle phases was calculated and the effect of alkyl chain length on Ρ is elucidated. Students used the diffusion coefficients of the micelles to calculate radii and compared the PFG-NMR results with those obtained from dynamic light scattering (DLS) experiments. 190

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Section: Figure 2 An Illustration Of a Micelle (In Polar Medium) Andmentioning

confidence: 99%

Dynamic NMR in an Advanced Laboratory

Odeh

2007

ACS Symposium Series

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“…The points of the characteristic function of the osmometer were calculated from these readings and from the mean activities according to Eq. [6]. These calculated points are plotted against the osmomolality readings in Fig.…”

Section: Figmentioning

confidence: 99%

“…Later, nonionic hydrotropes were also found (3,4). In the past decades, the application of hydrotropes became more and more important in the fields of different technological processes, viz., extraction, distillation, drug formulation, washing, microemulsion-formulation (5)(6)(7)(8)(9)(10)(11)(12)(13). Their practical importance has prompted many attempts to clarify the theoretical basis of hydrotropy during an 80-year time span.…”

Section: Introductionmentioning

confidence: 99%

The Hydrotrope Action of Sodium Xylenesulfonate on the Solubility of Lecithin

Horváth‐Szabó

Yin

Friberg

2001

Journal of Colloid and Interface Science

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“…Furthermore, hydrotrope aggregation is responsible for the increase in aqueous solubility that occurs beyond a certain hydrotrope concentration termed the minimum hydrotrope concentration (MHC), analogous to the critical micelle concentration (CMC) for a surfactant (5). Reviews are now available detailing the progress in hydrotrope research (6)(7)(8)(9)(10)(11).…”

mentioning

confidence: 99%

“…Despite the usefulness of hydrotropes in various applications (5), considerably less attention has been paid to understanding the aggregation behavior of hydrotropic compounds (8)(9)(10). This feature, and the fact that the MHC needed for hydrotropic action is high, suggest that hydrotropes with lower MHC would result in more useful systems hydrotropes.…”

mentioning

confidence: 99%

Additive‐induced association in unconventional systems: A case of the hydrotrope

Kumar

Parveen

Kabir-ud-Din

2005

J Surfact & Detergents

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It is well known that hydrotropes have a very high minimum hydrotrope concentration (MHC), posing a question on their applications. We have found that MHC (obtained by conductivity and surface tension measurements) can be reduced by the addition of foreign materials. The association tendency can be improved by the addition of salts, n-alkanols, and ureas. Urea decreases or increases the MHC depending on whether the urea content is lower or higher (e.g., the increased solubility of sparingly soluble riboflavin corroborates the increase in the hydrotropic properties of the system). In the present work, the association tendencies of sodium salicylate (a well-known hydrotrope), sodium dodecyl sulfate, and sodium bromide were compared. The results have direct implications in the mechanism of protein denaturation and may provide insight into the role of urea in supramolecular assemblies.The word hydrotropy was first used by Neuberg (1). This term is used to describe the phenomenon of increasing aqueous solubility of otherwise sparingly soluble organic compounds in solutions of certain organic salts (2). These salts, called hydrotropes, include sodium, potassium, calcium, and ammonium salts of aromatic acids or phenols. McKee (3) concluded that a rather high content of hydrotrope in water is required for its action to be displayed and that the phenomenon is similar to the salting-in process. Booth and Everson (4) showed that the solubility increase does not occur monotonically with hydrotrope concentration, but displays a sigmoidal character. Furthermore, hydrotrope aggregation is responsible for the increase in aqueous solubility that occurs beyond a certain hydrotrope concentration termed the minimum hydrotrope concentration (MHC), analogous to the critical micelle concentration (CMC) for a surfactant (5). Reviews are now available detailing the progress in hydrotrope research (6-11).The aqueous solubility of surfactants is limited by the formation of a liquid crystalline phase, which can be destabilized in the presence of a typical hydrotrope. The enhanced disorder resulting from the residence of the hydrotrope in the association structure of the condensed phase brings about morphological changes from liquid crystal to oil-in-water and bicontinuous regions (11,12). Guo et al. (11) observed that the addition of vitamin C (a hydrotrope) to a cetyltrimethylammonium bromide/1-pentanol/p-xylene/water system caused the area of micellar and inverse micellar regions to increase and ultimately coalesce, whereas the liquid crystalline region shrank.Many attempts have been made to compare hydrotropes with conventional surfactants over the past 45 years (13-16). Danielsson and Stenius (17) observed the aggregation behavior of sodium carboxylates and reported that octanoate and higher members form micelles whereas lower ones form hydrotropes. Firman et al. (18) concluded that a clear distinction between a simple hydrotropic salt and a conventional surfactant is difficult to make. In most cases, hydrotropes have a strong ionic g...

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Controlling the Size of Vesicles Prepared from Egg Lecithin using a Hydrotrope

Cited by 21 publications

References 10 publications

Dynamic NMR in an Advanced Laboratory

Dynamic NMR in an Advanced Laboratory

The Hydrotrope Action of Sodium Xylenesulfonate on the Solubility of Lecithin

Additive‐induced association in unconventional systems: A case of the hydrotrope

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