Controlling the phase and morphology of amorphous Se nanoparticles: their prolonged stabilization and anticancer efficacy

Guleria, Apurav; Chakraborty, S.P.; Neogy, S.; Adhikari, Sushil

doi:10.1039/c8cc05375h

Cited by 19 publications

(26 citation statements)

References 40 publications

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“…ABTS free radical scavenging activity for the as synthesized NPs was experimentally determined according to the method reported in literature. 30 0.70-0.80 at 734 nm. The NPs stock solution prepared had concentration 12.74 mg/ml (6.37 mg of NPs dispersed in 0.5 ml nanopure water).…”

Section: Antioxidant Studies By Abts Radical Scavenging Assaymentioning

confidence: 98%

Nontoxic photoluminescent tin oxide nanoparticles for cell imaging: deep eutectic solvent mediated synthesis, tuning and mechanism

et al. 2021

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Section: Antioxidant Studies By Abts Radical Scavenging Assaymentioning

confidence: 98%

Nontoxic photoluminescent tin oxide nanoparticles for cell imaging: deep eutectic solvent mediated synthesis, tuning and mechanism

et al. 2021

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“…Thus, co-metabolic degradation of phenol is more feasible at higher pH (7-8), and the efficiency of phenol degradation is almost doubled. Additionally, the reduction of selenite in the co-culture system produces Se(0) nanoparticles, which has potential anticancer effect, antimicrobial activity and has several applications in the field of pharmaceutical, medical and environmental sciences (Guleria et al 2018). PAH containing wastewater also contains toxic metal ions like Cr 2+ , Cd 2+ , Zn 2+ , As 3+ , As 5+ , Hg 2+ (Liu et al 2017) which may affect the selenite reducing capacity of the co-culture.…”

Section: Practical Applicationsmentioning

confidence: 99%

Biovalorisation of liquid and gaseous effluents of oil refinery and petrochemical industry

Chakraborty¹

2021

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The simultaneous removal of phenol and selenite from synthetic wastewater was investigated by adopting two different co-culturing techniques using the fungus Phanerochaete chrysosporium and the bacterium Delftia lacustris. Separately grown biomass of the fungus and the bacterium (suspended co-culture) was incubated with different concentrations of phenol (0-1200 mg/L) and selenite (10 mg/L). The selenite ions were biologically reduced to extracellular Se(0) nanoparticles (3.58 nm diameter) with the simultaneous degradation of up to 800 mg/L of phenol. Upon growing the fungus and the bacterium together using an attached growth co-culture, the bacterium grew as a biofilm onto the fungus. The extracellularly produced Se(0) in the attached growth co-culture had a minimum diameter of 58.5 nm. This co-culture was able to degrade completely 50 mg/L phenol, but was completely inhibited at a phenol concentration of 200 mg/L.

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“…11 Selenium nanoparticles (SeNPs) are considered of low or no cytotoxicity compared to other Se forms, with interesting biological activity and bioavailability as elemental SeNPs possess high selenium density that allows local delivery of high doses into the site of action. [12][13][14][15][16][17][18][19] SeNPs show promising prospects because of their widespread biomedical applications, including anticancer, [20][21][22] anti-inflammatory, 10 antioxidant, 19,23,24 and antimicrobial activity, 23,25,26 treatment of arthritis, 27 cerebral strokes, 28 and psoriasis. 29 Applications of SeNPs are attributed to their antioxidant-mediated anti-inflammatory properties; they could downregulate the inflammatory mediators, 30 improve the oxidative stress-mediated inflammation, and enhance the antioxidant defense.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Different Surface Coating Agents for Selenium Nanoparticles: Enhanced Anti-Inflammatory Activity and Drug Loading Capacity

Mekkawy¹,

Fathy²,

Mohamed³

2022

DDDT

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Background: Inflammation is the keystone in the disease's pathological process in response to any damaging stimuli. Therefore, any agent that inhibits the inflammatory response is under focus, either a drug or a bioactive compound. Selenium nanoparticles have drawn attention in various biomedical applications, including the anti-inflammatory activity. Purpose: In the current study, we aimed to evaluate the capacity of different surface coating materials (soybean lecithin, PEG 6000, and β-cyclodextrin) to enhance the anti-inflammatory activity of the synthesized selenium nanoparticles (SeNPs). The capability of the coated SeNPs to adsorb indomethacin (IND) on their surfaces compared to the uncoated SeNPs was also evaluated. Methods: SeNPs were synthesized, coated with different materials, and characterized in vitro using X-ray diffraction, UV-Vis spectrophotometer, FTIR, SEM, TEM, and particle size and zeta potential measurements. The in vivo anti-inflammatory activity of the uncoated/coated SeNPs loaded into hydrogel was evaluated using a carrageenan-induced paw edema rat model. The effect of SeNPs surface coatings was further evaluated for IND loading capacity. Results: Our findings proved the superior anti-inflammatory activity of all coated SeNPs compared to the uncoated SeNPs, especially with β-cyclodextrin surface coating. Regarding the IND loading capacity of the prepared uncoated/coated SeNPs, the amount of drug loaded was 0.12, 1.12, 0.3, and 0.14 µg IND/µg SeNPs for the uncoated, lecithin-, PEG-and β-CD-coated SeNPs, respectively. Conclusion: Surface functionalization of SeNPs can provide a synergistic therapeutic activity. Our results are promising for further investigation of the in vivo anti-inflammatory synergistic activity of the IND-loaded surface-coated SeNPs.

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Controlling the phase and morphology of amorphous Se nanoparticles: their prolonged stabilization and anticancer efficacy

Cited by 19 publications

References 40 publications

Nontoxic photoluminescent tin oxide nanoparticles for cell imaging: deep eutectic solvent mediated synthesis, tuning and mechanism

Nontoxic photoluminescent tin oxide nanoparticles for cell imaging: deep eutectic solvent mediated synthesis, tuning and mechanism

Biovalorisation of liquid and gaseous effluents of oil refinery and petrochemical industry

Evaluation of Different Surface Coating Agents for Selenium Nanoparticles: Enhanced Anti-Inflammatory Activity and Drug Loading Capacity

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