Controlling the dissolution of iron through the development of nanostructured Fe-Mg for biomedical applications

Khan, Muhammad Mudasser; Deen, Kashif Mairaj; Shabib, Ishraq; Asselin, Edouard; Haider, Waseem

doi:10.1016/j.actbio.2020.06.014

Cited by 19 publications

(8 citation statements)

References 105 publications

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“…The FFT results presented a number of explicit diffraction points in pairs rather than indefinite halo rings, indicating a typical crystal characterization. 27 The interplanar spacing was obtained by measuring the lattice fringes in different directions. In particular, the γ-austenite plane (111) with a crystal plane spacing of 0.211 nm and the ε-martensite plane (103) with a crystal plane spacing of 0.123 nm were observed in region 1.…”

Section: Resultsmentioning

confidence: 73%

“…To further inquire into the lattice structure, two regions in Figure c were selected to process the fast Fourier transform (FFT), filtered FFT, and inverse FFT (Figure d–i). The FFT results presented a number of explicit diffraction points in pairs rather than indefinite halo rings, indicating a typical crystal characterization . The interplanar spacing was obtained by measuring the lattice fringes in different directions.…”

Section: Resultsmentioning

confidence: 99%

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Stress-Induced Dual-Phase Structure to Accelerate Degradation of the Fe Implant

Shuai

Zhong

Dong

et al. 2022

ACS Biomater. Sci. Eng.

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Fe is considered as a potential candidate for implant materials, but its application is impeded by the low degradation rate. Herein, a dual-phase Fe30Mn6Si alloy was prepared by mechanical alloying (MA). During MA, the motion of dislocations driven by the impact stress promoted the solid solution of Mn in Fe, which transformed α-ferrite into γ-austenite since Mn was an austenite-stabilizing element. Meanwhile, the incorporation of Si decreased the stacking fault energy inside austenite grains, which tangled dislocations into stacking faults and acted as nucleation sites for ε-martensite. Resultantly, Fe30Mn6Si powder had a dualphase structure composed of 53% γ-austenite and 47% εmartensite. Afterward, the powders were prepared into implants by selective laser melting. The Fe30Mn6Si alloy had a more negative corrosion potential of −0.76 ± 0.09 V and a higher corrosion current of 30.61 ± 0.41 μA/cm 2 than Fe and Fe30Mn. Besides, the long-term weight loss tests also proved that Fe30Mn6Si had the optimal degradation rate (0.25 ± 0.02 mm/year).

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Section: Resultsmentioning

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Stress-Induced Dual-Phase Structure to Accelerate Degradation of the Fe Implant

Shuai

Zhong

Dong

et al. 2022

ACS Biomater. Sci. Eng.

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show abstract

“…It is worth noting that the specific values of hardness and elastic modulus for the PIL were clearly the smallest compared to traditional biomedical implants, PDL [ 60 ] and chitosan [ 61 ] (Figure 4b), whereas the stiffness of the PIL is almost the same as that of human bone. However, the energy‐dissipative properties of traditional biomedical implants with high elastic moduli are prone to degenerate gradually because of their lower energy dissipation, such as Carbon–Ti, [ 62 ] Fe–Mg, [ 63 ] Ti6Al4V, [ 64 ] NiTi, [ 64 ] titanium, Ti–Zr–Nb–Mo, [ 65 ] Ti–Nb–Mg, [ 66 ] Ti–Nb–Zr–Ta, [ 67 ] Ti–24Nb–4Zr, [ 68 ] and Ti–Nb–Zr–Co. [ 68 ] However, owing to the periodontium‐mimetic architecture of the current polymer‐infiltrated amorphous titania‐nanotube‐array, the PIL could simultaneously enhance the osteointegration and energy‐dissipation.…”

Section: Resultsmentioning

confidence: 99%

An Amorphous Peri‐Implant Ligament with Combined Osteointegration and Energy‐Dissipation

et al. 2021

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Progress toward developing metal implants as permanent hard‐tissue substitutes requires both osteointegration to achieve load‐bearing support, and energy‐dissipation to prevent overload‐induced bone resorption. However, in existing implants these two properties can only be achieved separately. Optimized by natural evolution, tooth‐periodontal‐ligaments with fiber‐bundle structures can efficiently orchestrate load‐bearing and energy dissipation, which make tooth–bone complexes survive extremely high occlusion loads (>300 N) for prolonged lifetimes. Here, a bioinspired peri‐implant ligament with simultaneously enhanced osteointegration and energy‐dissipation is presented, which is based on the periodontium‐mimetic architecture of a polymer‐infiltrated, amorphous, titania nanotube array. The artificial ligament not only provides exceptional osteoinductivity owing to its nanotopography and beneficial ingredients, but also produces periodontium‐similar energy dissipation due to the complexity of the force transmission modes and interface sliding. The ligament increases bone–implant contact by more than 18% and simultaneously reduces the effective stress transfer from implant to peri‐implant bone by ≈30% as compared to titanium implants, which as far as is known has not previously been achieved. It is anticipated that the concept of an artificial ligament will open new possibilities for developing high‐performance implanted materials with increased lifespans.

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“…Biodegradable metals (BMs), represented by magnesium-, zinc-, and iron-based alloys, are expected to degrade or corrode gradually in vivo after performing their supportive assisting functions during tissue healing or disease diagnosis, under the influence of appropriate host responses. Compared with their polymeric counterparts, BMs possess higher mechanical strength and show better performance as cardiovascular stents and bone implants [ [1] , [2] , [3] ]. Several reviews have presented the state-of-the-art technologies in developing BMs-based degradable biomedical implants [ [4] , [5] , [6] , [7] ].…”

Section: Introductionmentioning

confidence: 99%

Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials

Jiang

Gao

et al. 2022

Bioactive Materials

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Over the past two decades, biodegradable metals (BMs) have emerged as promising materials to fabricate temporary biomedical devices, with the purpose of avoiding potential side effects of permanent implants. In this review, we first surveyed the current status of BMs in neuroscience, and briefly summarized the representative stents for treating vascular stenosis. Then, inspired by the convincing clinical evidence on the in vivo safety of Mg alloys as cardiovascular stents, we analyzed the possibility of producing biodegradable cerebrovascular Mg alloy stents for treating ischemic stroke. For these novel applications, some key factors should also be considered in designing BM brain stents, including the anatomic features of the cerebral vasculature, hemodynamic influences, neuro-cytocompatibility and selection of alloying elements. This work may provide insights into the future design and fabrication of BM neurological devices, especially for brain stents.

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Controlling the dissolution of iron through the development of nanostructured Fe-Mg for biomedical applications

Cited by 19 publications

References 105 publications

Stress-Induced Dual-Phase Structure to Accelerate Degradation of the Fe Implant

Stress-Induced Dual-Phase Structure to Accelerate Degradation of the Fe Implant

An Amorphous Peri‐Implant Ligament with Combined Osteointegration and Energy‐Dissipation

Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials

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