Controlling the buckling instability of drying droplets of suspensions through colloidal interactions

Lintingre, Eric; Ducouret, Guylaine; Lequeux, François; Olanier, Ludovic; Périé, Thomas; Talini, Laurence

doi:10.1039/c5sm00283d

Cited by 36 publications

(42 citation statements)

References 20 publications

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“…The effect of the Darcy pressure is to lower the energy barrier to overcome for particles to aggregate. 27 The needed value of the Darcy pressure for aggregation nevertheless remains smaller than its maximum value, calculated for the more drastic conditions provided by strongly charged particles suspended in a low ionic strength electrolyte. Thus, for usual mineral suspensions for which the Hamaker constant is ≈ 10 −20 , a lower value of salt concentration 10 −4 .…”

Section: Shell Buckling and Colloidal Interactionsmentioning

confidence: 90%

“…This set-up was applied to study the drying mechanism of colloidal suspensions with an excellent correlation between Leidenfrost and spray drying results. [25][26][27]: Examples of grains obtained after the drying of a droplet of a nanoparticle suspension using the Leidenfrost effect. 27 The scale bar represents 1mm.…”

Section: Single Droplet Experiments To Mimic Spray Dryingmentioning

confidence: 99%

“…[25][26][27]: Examples of grains obtained after the drying of a droplet of a nanoparticle suspension using the Leidenfrost effect. 27 The scale bar represents 1mm.…”

Section: Single Droplet Experiments To Mimic Spray Dryingmentioning

confidence: 99%

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Control of particle morphology in the spray drying of colloidal suspensions

et al. 2016

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Powders of nanoparticles are volatile, i.e. easily disperse in air, which makes their handling difficult. Granulation of nanoparticle powders provides a solution to that issue, and it is generally performed by spray drying the nanoparticles that have been suspended in a liquid. Spray drying of a colloidal suspension consists of atomising the suspension into droplets by a fast flowing and hot gas. Once the droplets dried, the resulting dry grains/microparticles can be used in a wide range of applications - food, pharmaceutics, fillers, ceramics, etc. It is well known that the grains resulting from spray-drying may be spherical but may also exhibit other diverse morphologies. Although different influencing parameters have been identified, no clear overview can be found in the literature for the driving mechanisms of grain shaping. In the present work, we review the assumptions made in the literature to explain the different morphologies. We analyse the orders of magnitude of the different effects at stake and show that the grain shape does not result from a hydrodynamic instability but is determined by the drying stage. However, we emphasize that neither the drying time nor the associated Péclet number are critical parameters for the determination of shape morphology. In light of those results, we also review and discuss the single droplet experiments developed to mimic spray drying. Generalising our previous works, we further analyse how the control of morphology can be achieved by tuning the colloidal interactions in the suspension. We detail the model we have developed that relates the colloidal interaction potential to a critical pressure exerted by the solvent as it flows, and we provide a quantitative prediction of the grain shape. Finally, we offer perspectives with regard to spray drying of systems such as molecular solutions, widely performed in e.g. the pharmaceutical industry.

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Section: Shell Buckling and Colloidal Interactionsmentioning

confidence: 90%

Section: Single Droplet Experiments To Mimic Spray Dryingmentioning

confidence: 99%

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Control of particle morphology in the spray drying of colloidal suspensions

et al. 2016

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“…The morphology of particles can be strongly influenced by the formation of bubbles in relation to the initial nucleation within the droplets [40]. Various methods to investigate single droplet drying mechanisms have been reported, such as using a glass filament [41], hydrophobic surfaces [34], acoustic levitation [42][43][44], aerodynamic levitation [45] and leidenfrost drop forms [20,46,47]. Herein, hot stage microscopy was employed, wherein a hydrophobic surface was created to investigate the impact of gas bubbles on the morphology of the spray-dried particles.…”

Section: Morphologymentioning

confidence: 99%

“…Such inconsistencies may be attributed to the independent examination of individual properties rather than within the complete system. Nevertheless, the above mentioned studies emphasize the importance of drug carriers engineering in enhancing aerosol performance in DPI [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Combined control of morphology and polymorph in spray drying of mannitol for dry powder inhalation

Lyu

Liu

Zhang

et al. 2017

Journal of Crystal Growth

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The morphology and polymorphism of mannitol particles were controlled during spray drying with the aim of improving the aerosolization properties of inhalable dry powders. The obtained microparticles were characterized using scanning electron microscopy, infrared spectroscopy, differential scanning calorimetry, powder X-ray diffraction and inhaler testing with a next generation impactor. Mannitol particles of varied -mannitol content and surface roughness were prepared via spray drying by manipulating the concentration of NH 4 HCO 3 in the feed solution. The bubbles produced by NH 4 HCO 3 led to the formation of spheroid particles with a rough surface. Further, the fine particle fraction was increased by the rough surface of carriers and the high -mannitol content.Inhalable dry powders with a 29.1 ± 2.4% fine particle fraction were obtained by spray-drying using 5% mannitol (w/v)/2% NH 4 HCO 3 (w/v) as the feed solution, proving that this technique is an effective method to engineer particles for dry powder inhalation.

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Hybrid Inorganic–Organic Luminescent Supraparticle Taggants with Switchable Dual‐Level ID

Miller

Reichstein

Mandel

2022

Advanced Optical Materials

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Tracking and tracing of objects are of paramount importance for realizing a Circular Economy and can be achieved by incorporating micrometer‐scaled luminescent identification (ID) taggants. While established systems are passive, displaying merely an ID feature, for monitoring a products’ life cycle, conscious taggants with stimuli‐triggered switchable ID signals, e.g., to record a recycling step, are desired. Herein, micrometer‐scaled hybrid inorganic–organic taggants with a temperature‐triggered switchable luminescent ID are reported. They are produced by assembling eight different types of organic and inorganic nanoparticles (NPs) via a two‐step spray‐drying process into supraparticles (SPs) with a core–shell structure. This hierarchical structure and well‐balanced mass‐ratios of the utilized nanosized building blocks are key to controlling the occurring coupling effects within SPs, thus, to obtain the switchable ID functionality. Initially, the temperature‐inert inorganic luminescent ID‐level, located in the core, is concealed by a mutable organic ID‐level, emitted by the shell. Upon specific heat treatment, the ID is switched by irreversible quenching of the organic ID‐level, revealing the inorganic ID‐level. Furthermore, both ID‐levels are read out ratiometrically using the same excitation wavelength for their detection. Based on the SPs’ toolbox‐like manufacturing, the ID signals are adjustable to yield the demanded code variety on both ID‐levels.

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Controlling the buckling instability of drying droplets of suspensions through colloidal interactions

Cited by 36 publications

References 20 publications

Control of particle morphology in the spray drying of colloidal suspensions

Control of particle morphology in the spray drying of colloidal suspensions

Combined control of morphology and polymorph in spray drying of mannitol for dry powder inhalation

Hybrid Inorganic–Organic Luminescent Supraparticle Taggants with Switchable Dual‐Level ID

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