Controlling Systemic Inflammation by Careful Formulation of Topical Skin Care Products: Our Bodies Didn’t Evolve With All the Current Chemicals in Skin Care Products

Abstract

Although man is still rapidly evolving, he has not co-evolved with all of the modern chemicals made by man, including those in cosmetic products. Care must be taken when formulating products so that commonly used ingredients, such as polyethylene glycol, can be substituted with safer ingredients to which man has adapted and that will not cause irritation and inflammation. This is especially important given that induction of skin inflammation will cause systemic inflammation. A review of the literature and of commercially available products was made to highlight techniques and products that remediate inflammation or induce inflammation. Many skin care products contain chemicals that induce irritation and inflammation that may lead to chronic, systemic inflammation. Well studied natural products, especially skin identical chemicals, may offer an advantage compared to recent man-made chemicals in cosmetic and topical formulations and help to reduce skin inflammation as well as skin derived systemic chronic inflammation.

Better Preventing and Mitigating the Effects of Covid-19

“…While humans continue to genetically and epigenetically coadapt with our planet, increasing population, rapid and extensive interactions with fellow humans and other organisms, including zoonotic viruses, means that adaptation in humans will not occur as rapidly as that of other biological entities, such as some viruses, which can internally coevolve their subunits in few passages [85]. Nor will humans adapt rapidly enough to remain healthy in an ever changing and expanding exposome, including the newly made more than 2000 chemicals created every year [86]. To better live with the rapidly changing environment being created, new therapeutic strategies must emerge, for example, using systems therapeutics for physiological renormalization [87,88] to bring our bodies into a state of allostasis [89], where the immune system components are in balance to fight infection, and inflammation can be properly resolved.…”