Controlling solid lipid nanoparticle adhesion by polyelectrolyte multilayer surface modifications

Finke, Jan Henrik; Schmolke, Hannah; Klages, Claus‐Peter; Müller‐Goymann, Christel C.

doi:10.1016/j.ijpharm.2013.03.061

Cited by 12 publications

(7 citation statements)

References 45 publications

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“…This approach can be repeated many times to form multiple layers around a colloidal particle. The LbL approach has previously been used to coat lipid droplets (Guzey and McClements ), SLNs (Finke and others ), liposomes (Laye and others ; Chun and others ), and microgels (Zhao and others ). Other coating approaches include complex coacervation and Pickering stabilization.…”

Section: Overview Of Colloidal Delivery Systemsmentioning

confidence: 99%

Delivery by Design (DbD): A Standardized Approach to the Development of Efficacious Nanoparticle‐ and Microparticle‐Based Delivery Systems

McClements

2017

Comp Rev Food Sci Food Safe

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The design and development of nanoparticle‐ and microparticle‐based delivery systems for the encapsulation, protection, and controlled release of active agents has grown considerably in the agrochemical, cosmetic, food, personal care, and pharmaceutical industries. These colloidal delivery systems can be utilized to overcome problems such as poor solubility, low activity, and chemical instability of active agents, as well as to create novel functional attributes such as controlled or targeted delivery. The purpose of this article is to develop a systematic approach, referred to as “delivery‐by‐design” (DbD), to make the design and fabrication process more efficient and effective. Initially, a brief review of some of the challenges associated with incorporating active agents into commercial products is given, and then an overview of different kinds of simple and complex colloidal delivery systems is given. The DbD approach is then presented as a series of stages: (1) definition of the molecular and physicochemical properties of the active agent; (2) definition of the required physicochemical, sensory, and functional attributes of the end‐product; (3) specification of the required attributes of the colloidal delivery system; (4) specification of particle properties and delivery system selection; (5) optimization of delivery system manufacturing process; (6) establishment and implementation of delivery system testing protocol; and (7) optimization of delivery system performance. Utilization of the DbD approach may lead to more rapid design of efficacious and economically viable colloidal delivery systems for commercial applications.

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Section: Overview Of Colloidal Delivery Systemsmentioning

confidence: 99%

Delivery by Design (DbD): A Standardized Approach to the Development of Efficacious Nanoparticle‐ and Microparticle‐Based Delivery Systems

McClements

2017

Comp Rev Food Sci Food Safe

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“…Previous work of our group showed that, due to a negative zeta potential, lipid nanoparticles adsorbed to steel surfaces coated with positively charged polyelectrolytes. 42 Molecular Pharmaceutics As poly-D-lysine also represents a positively charged polyelectrolyte, nanocarriers might adsorb to the coated glass surfaces. However, this effect is negligible due to the same coating for well plates and microchannels with the additional subtraction of intercellular fluorescence from intracellular fluorescence.…”

Section: Discussionmentioning

confidence: 99%

Cellular Uptake of Coumarin-6 under Microfluidic Conditions into HCE-T Cells from Nanoscale Formulations

et al. 2014

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Intact SLN were not incorporated into the cells, i.e., C-6 was passively redistributed from SLN to lipophilic cellular compartments. C-6 was enriched up to a given limit in HCE-T cells within 5 min of contact with the dispersions both under static and under flow conditions. The C-6 delivery rate from liposomes was superior to that from SLN whereby the suspension exhibited the lowest rate. C-6 release rates were comparable for static and flow conditions. Alternate flushing with formulations and buffer revealed that cells accumulated C-6. The results suggest that combining microfluidics with live cell imaging provides a valuable option for in vitro studies of ocular drug delivery.

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“…As previously mentioned, SLNs and NLCs present several advantages for topical administration of ophthalmic drugs, such as (3,14,15,25,26,29,40,41,58,(81)(82)(83)(84)(85)(86)(87): the ability to entrap lipophilic drugs, which extend their residence time and slow drainage, when compared to the conventional ophthalmic formulations; protection of the drugs from eye enzymatic degradation; adhesion to the ocular surface and interaction with the epithelium, depending on the nanoparticles size, shape and surface charge; lipid components might interact with the lipid layer of the tear film, enhancing the transcorneal drug delivery and prolonging the pre-corneal retention in the conjunctiva sac, which increases the ocular bioavailability of drugs.…”

Section: Lipid Nanoparticlesmentioning

confidence: 99%

“…Nanoparticles coated, dissolved or suspended in mucoadhesive polymers or in situ gelling (i.e. stimuli-responsive) polymers increase pre-corneal residence time and promote drug absorption (5,6,11,16,29,(32)(33)(34)(35)(36)(37)(38)(39)(40).…”

Section: Introductionmentioning

confidence: 99%

Applications of Polymeric and Lipid Nanoparticles in Ophthalmic Pharmaceutical Formulations: Present and Future Considerations

et al. 2014

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The unique properties and characteristics of ocular tissues and the whole set of defence mechanisms of the ocular globe make the instillation of ocular drugs into a difficult task with a low rate of therapeutic response. One of the challenges for the new generation of ophthalmic pharmaceutical formulations is to increase the bioavailability of drugs administered by the ocular route and, therefore, their therapeutic efficacy. This can be achieved with the use of some strategies that provide an increase in the formulation pre-corneal residence time, mucoadhesion and penetration across the eye tissues. Colloidal carrier systems have been very successfully used for the selective and targeted delivery of drugs for several routes of administration. In this context, nanoparticles prepared with specific polymers or lipids and coated, dispersed or suspended in polymer solutions with mucoadhesion properties or in situ gelling properties will be an excellent strategy that deserves attention and further research. In this review, the characteristics and main properties of polymeric and lipid nanoparticles are discussed and examples and advantages of the application of these colloidal carrier systems for the ophthalmic administration of drugs are presented. The future directions of the research required in this specific field are also presented.

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Controlling solid lipid nanoparticle adhesion by polyelectrolyte multilayer surface modifications

Cited by 12 publications

References 45 publications

Delivery by Design (DbD): A Standardized Approach to the Development of Efficacious Nanoparticle‐ and Microparticle‐Based Delivery Systems

Delivery by Design (DbD): A Standardized Approach to the Development of Efficacious Nanoparticle‐ and Microparticle‐Based Delivery Systems

Cellular Uptake of Coumarin-6 under Microfluidic Conditions into HCE-T Cells from Nanoscale Formulations

Applications of Polymeric and Lipid Nanoparticles in Ophthalmic Pharmaceutical Formulations: Present and Future Considerations

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