Controlling Nutritional Status Score Predicts In-Hospital Mortality in Acute Pulmonary Embolism

Abstract

Objective: This is the first study examining the value of CONUT score in assessing malnutrition among acute pulmonary embolism patients. We showed that the presence of malnutrition defined by the CONUT score predicts in-hospital mortality following acute pulmonary embolism.The association between the nutritional status and outcomes in pulmonary embolism is unclear. Therefore, we aimed to assess the association between Controlling Nutritional Status (CONUT) score, and in-hospital mortality in patients with acute pulmonary embolism. Subject and Methods: We retrospectively reviewed the records of all adult patients with acute pulmonary embolism hospitalized through our ED. Demographic, clinical, and laboratory data on admission were recorded. Nutritional status was assessed with the CONUT score, which is calculated by the albumin, total cholesterol, and lymphocyte counts. The primary endpoint of the study was in-hospital mortality. Results: A total of 308 consecutive patients (mean age 68.2 ± 12.9 years, 53.9 % female) were included, and 35 of the patients (11.4%) died during their in-hospital course. Multivariate analysis showed that pulmonary embolism severity index >148 (OR 3.12, 95% CI 1.65-8.81, p< 0.001), presence of heart failure (1.25, 95% CI 1.08-1.78, p= 0.03), and CONUT score> 4 (OR 1.39, 95% CI 1.146-3.424, p= 0.015) were independent predictors of in-hospital mortality. Conclusion: The present study indicates that the presence of malnutrition defined by the CONUT score predicts in-hospital mortality following acute pulmonary embolism.

Prognostic Nutritional Index, Controlling Nutritional Status (CONUT) Score, and Inflammatory Biomarkers as Predictors of Deep Vein Thrombosis, Acute Pulmonary Embolism, and Mortality in COVID-19 Patients

“…In terms of all inflammatory and nutritional markers’ optimal cut-off value regarding the non-COVID APE patients, Efros et al [ 38 ] demonstrated that an NLR > 5.12 (OR:2.82; p < 0.001) and malignancy (OR:1.72; p < 0.001) are predictors of 30-day mortality in 2072 patients with APE. Moreover, Yildirim et al [ 63 ] concluded that a CONUT Score > 4 (OR:1.39; p = 0.01) was an independent predictor of in-hospital mortality, in 308 consecutive non-COVID patients. Also, Hayiroglu et al [ 64 ] demonstrated that PNI > 38 (AUC:0.79; p < 0.001) is an independent prognostic factor for survival in 251 patients with APE.…”

Effect of malnutrition on outcomes of hospitalisations for acute pulmonary embolism: a national inpatient database study

“…There are only a few studies that have assessed the impact of malnutrition in patients with PE 19 20. A previous retrospective study, which assessed nutritional status by the Controlling Nutritional Status score, calculated by the albumin, total cholesterol and lymphocyte counts, reported that up to 56.8% of patients with PE have concurrent malnutrition 19.…”

“…There are only a few studies that have assessed the impact of malnutrition in patients with PE 19 20. A previous retrospective study, which assessed nutritional status by the Controlling Nutritional Status score, calculated by the albumin, total cholesterol and lymphocyte counts, reported that up to 56.8% of patients with PE have concurrent malnutrition 19. In our study, which involved a large patient population from multiple centres in the USA, we observed a much lower prevalence of concurrent malnutrition in PE compared with previous reports, both specifically in PE patients and hospitalised patients in general.…”

Controlling nutritional status score during hospitalization as a predictor of clinical outcome in patients with aneurysmal subarachnoid hemorrhage

“…The CONUT score was developed to screen for undernutrition in hospital populations 12 . Numerous studies have reported an association between short- and/or long-term clinical outcomes and CONUT score in various acute diseases, including heart failure 13 , 14 , coronary syndrome 15 , myocardial infarction 16 , pulmonary embolism 17 and ischemic and hemorrhagic stroke 7 , 18 , 19 . In contrast, few reports have examined the association of changes in CONUT score during hospitalization with clinical outcomes.…”