Controlling Nutritional Status (CONUT) Score as a New Indicator of Prognosis in Patients With Hilar Cholangiocarcinoma Is Superior to NLR and PNI: A Single-Center Retrospective Study

Wang, Ankang; He, Zhenxing; Peng, Cong; Qu, Yueyu; Hu, Tao; Cai, Yu; Sun, Bo; Hao, Chunyan; Fu, Wenguang; Peng, Yong

doi:10.3389/fonc.2020.593452

Cited by 28 publications

(38 citation statements)

References 54 publications

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“…Our findings align with previous studies exploring the predictive role of the CONUT score in the setting of hepatic (10,(25)(26)(27), thoracic, urological, and gastrointestinal oncological surgery (28)(29)(30)(31)(32). A study from China (N = 94) showed that pre-operative CONUT was the best predictor of overall and recurrence-free survivals in patients resected for hilar cholangiocarcinoma (10).…”

Section: Discussionsupporting

confidence: 90%

“…The CONUT score was calculated according to the original descriptions (9)(10)(11)(12). The CONUT score is based on serum albumin, cholesterol, and total lymphocyte count.…”

Section: Definitionsmentioning

confidence: 99%

“…Malnutrition and immunological status can influence treatment outcomes, with various studies weighing their impact after surgery (6)(7)(8). The Controlling Nutritional Status (CONUT) score has been developed to measure both aspects and has been trialed in different settings, including cancer surgery and oncologic treatments (9)(10)(11)(12). The CONUT score has been tested with the intent to predict overall survival and hepatocellular cancer (HCC) recurrence after LT and post-operative complications in pancreatic, esophageal, gastrointestinal, and orthopedic surgery (13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

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CONUT Score Predicts Early Morbidity After Liver Transplantation: A Collaborative Study

et al. 2022

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Introduction: Liver transplantation (LT) is burdened by the risk of post-operative morbidity. Identifying patients at higher risk of developing complications can help allocate resources in the perioperative phase. Controlling Nutritional Status (CONUT) score, based on lymphocyte count, serum albumin, and cholesterol levels, has been applied to various surgical specialties, proving reliable in predicting complications and prognosis. Our study aims to investigate the role of the CONUT score in predicting the development of early complications (within 90 days) after LT.Methods: This is a retrospective analysis of 209 patients with a calculable CONUT score within 2 months before LT. The ability of the CONUT score to predict severe complications, defined as a Comprehensive Complication Index (CCI) ≥42.1, was examined. Inverse Probability Treatment Weighting was used to balance the study population against potential confounders.Results: Patients with a CCI ≥42.1 had higher CONUT score values (median: 7 vs. 5, P-value < 0.0001). The CONUT score showed a good diagnostic ability regarding post-LT morbidity, with an AUC = 0.72 (95.0%CI = 0.64–0.79; P-value < 0.0001). The CONUT score was the only independent risk factor identified for a complicated post-LT course, with an odds ratio = 1.39 (P-value < 0.0001). The 90-day survival rate was 98.8% and 87.5% for patients with a CONUT score <8 and ≥8, respectively.Conclusions: Pre-operative CONUT score is a helpful tool to identify patients at increased post-LT morbidity risk. Further refinements in the score composition, specific to the LT population, could be obtained with prospective studies.

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Section: Discussionsupporting

confidence: 90%

“…The CONUT score was calculated according to the original descriptions (9)(10)(11)(12). The CONUT score is based on serum albumin, cholesterol, and total lymphocyte count.…”

Section: Definitionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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CONUT Score Predicts Early Morbidity After Liver Transplantation: A Collaborative Study

et al. 2022

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“…Prognostic nutritional index (PNI) is a comprehensive and novel biomarker of inflammation based on albumin levels and lymphocytes 20‐22 . The PNI was initially used for prognostic assessment of patients with cancer 22,23 ; however, at present, it is thought to better reflect the inflammatory status and nutritional status of patients 24,25 . The role of PNI in the prognoses of patients with sepsis remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…20 , 21 , 22 The PNI was initially used for prognostic assessment of patients with cancer 22 , 23 ; however, at present, it is thought to better reflect the inflammatory status and nutritional status of patients. 24 , 25 The role of PNI in the prognoses of patients with sepsis remains unclear. Thus, we reasonably hypothesized that a high PNI would indicate higher mortality in sepsis patients, given their enhanced levels of inflammation and poorer nutritional statuses.…”

Section: Introductionmentioning

confidence: 99%

Prognostic nutrition index is associated with the all‐cause mortality in sepsis patients: A retrospective cohort study

Zhou

Kong

et al. 2022

Clinical Laboratory Analysis

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Sepsis is caused by an aberrant regulatory host response toward an infection. It is linked to acute organ dysfunction and associated with high mortality. 1,2 Despite advances in care and treatment, sepsis remains the costliest disease to treat, with over $20 billion (5.2%) being spent annually in the United States. 3 The number of hospitalizations for sepsis cases in the United States even exceeds those for stroke and myocardial infarctions. 4 According to the statistics, 5 the incidence of sepsis is 500 per 100,000 cases and is on the rise. Globally, there are over 31 million sepsis cases; among them, 19.4 million cases are of severe sepsis associated with a mortality

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Risk factors of postoperative bile leakage after liver resection: A systematic review and meta‐analysis

et al. 2023

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ObjectivePostoperative bile leakage (POBL) is one of the most common complications after liver resection. However, current studies on the risk factors for POBL and their impacts on surgical outcomes need to be more consistent. This study aims to conduct a meta‐analysis to analyze the risk factors for POBL after hepatectomy.MethodsWe incorporated all eligible studies from Embase, PubMed, and the Web of Science database (until July 2022) into this study. RevMan and STATA software were used to analyze the extracted data.ResultsA total of 39 studies, including 43,824 patients, were included in this meta‐analysis. We found that gender, partial hepatectomy, repeat of hepatectomy, extended hepatectomy, abdominal drain, diabetes, Child≥B, solitary tumor, and chemotherapy are the factors of grade B and C POBL. Some recognized risk factors were considered potential risk factors for grade B and C bile leakage because no subgroup analysis was performed, like HCC, cholangiocarcinoma, major resection, posterior sectionectomy, bi‐segmentectomy, S4 involved, S8 involved, central hepatectomy, and bile duct resection/reconstruction. Meanwhile, cirrhosis, benign diseases, left hepatectomy, and Segment 1 resection were not significant for grade B and C bile leakage. The influence of lateral sectionectomy, anterior sectionectomy, S1 involved, S3 involved, high‐risk procedure, laparoscope, and blood loss>1000 mL on POBL of ISGLS needs further research. Meanwhile, POBL significantly influenced overall survival (OS) after liver resection.ConclusionsWe identified several risk factors for POBL after hepatectomy, which could prompt the clinician to decrease POBL rates and make more beneficial decisions for patients who underwent the hepatectomy.

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Controlling Nutritional Status (CONUT) Score as a New Indicator of Prognosis in Patients With Hilar Cholangiocarcinoma Is Superior to NLR and PNI: A Single-Center Retrospective Study

Cited by 28 publications

References 54 publications

CONUT Score Predicts Early Morbidity After Liver Transplantation: A Collaborative Study

CONUT Score Predicts Early Morbidity After Liver Transplantation: A Collaborative Study

Prognostic nutrition index is associated with the all‐cause mortality in sepsis patients: A retrospective cohort study

Risk factors of postoperative bile leakage after liver resection: A systematic review and meta‐analysis

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