Controlling Hydrogel Properties by Crystallization of Hydrophobic Domains

Sanabria-DeLong, Naomi; Agrawal, Saumya; Bhatia, Surita R.; Tew, Gregory N.

doi:10.1021/ma052243n

Cited by 54 publications

(51 citation statements)

References 30 publications

(41 reference statements)

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“…57 Two studies on ABA triblocks were reported. 49,58 In the first study, two series of polymers were investigated where the B block was kept constant; EO based, while the A block was varied by being based either on GA and LLA or GA and DLLA. 49 The copolymers of each series possessed different compositions; discussed previously.…”

Section: Effect Of Stereochemistrymentioning

confidence: 99%

“…49 In the second study ABA triblocks copolymers with A and B based on LLA or DLLA and EO, respectively, were studied by visual and rheological tests. 58 According to visual tests, above a certain concentration, the LLA and DLLA based copolymers did and did not gel, respectively. After rheological measurements, the stiffness of the gel reduced with the same order.…”

Section: Effect Of Stereochemistrymentioning

confidence: 99%

“…The crystallinity and the amorphous structure of the of LLA and DLLA based, respectively, were found to be responsible for their differences. 58 In summary, it is not easy to predict how the stereochemistry affects the gelation as this is also associated with the polymer composition but it should be kept in mind that the stereochemistry of the polymer does have an impact and can really influence the gelation and the properties of the gel.…”

Section: Effect Of Stereochemistrymentioning

confidence: 99%

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Tuning the gelation of thermoresponsive gels

Constantinou

Georgiou

2016

European Polymer Journal

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Thermoresponsive gels are exciting polymeric materials with many biomedical applications in medical devices, drug delivery, tissue engineering and bio-printing. Also, they have great potential to be used in 3-D printing and thus in the fabrication of many different devices and materials. As it is crucial for the application of these gels to be able to control and tailor the gelation temperature and concentration this was the main focus and point of discussion of this feature article. Thus, it is discussed in detail how by varying the molar mass, composition, stereochemistry and architecture the thermoresponsive properties of these gels are altered.

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Section: Effect Of Stereochemistrymentioning

confidence: 99%

Section: Effect Of Stereochemistrymentioning

confidence: 99%

Section: Effect Of Stereochemistrymentioning

confidence: 99%

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Tuning the gelation of thermoresponsive gels

Constantinou

Georgiou

2016

European Polymer Journal

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“…Poly(D-lactide) (PDLA) and poly(L-lactide) (PLLA) are isotactic and semicrystalline. Meanwhile, materials formed by atactic poly(D,L-lactide), or racemic poly(R-lactide) (PRLA), are amorphous [45]. This allowed direct control over the crystallinity of the hydrophobic micelle formed by these triblock copolymers.…”

Section: Pla-peo-pla Triblock Copolymers Synthesismentioning

confidence: 99%

“…This includes the ability to varying the stiffness of these hydrogels by manipulating the length of the PLA endblocks [44], by changing the physical cross-links from amorphous to crystalline PLA [45], by varying the synthetic technique [46], by incorporating nanoparticles [47], and by covalently capturing the self-assembled structure [48]. This last approach is particularly intriguing since it combines the advantages of self-assembly with the stability of covalent cross-links.…”

Section: Introductionmentioning

confidence: 99%

PLA–PEO–PLA Hydrogels and Their Mechanical Properties

Tew

Bhatia

2011

Engineering Biomaterials for Regenerative Medicine

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Poly(lactide) -block -poly(ethylene oxide) -block -poly(lactide) [PLA-PEO-PLA] triblock copolymers are known to form physical hydrogels in water, due to the polymer's amphiphilic architecture. Their biodegradability has made them attractive for use as soft tissue scaffolds and other biological applications such as drug delivery. In many cases, their mechanical properties have been poorly investigated and "rules" for tuning their stiffness are missing. Often the network junction points are only physical cross-links, not covalent, and in a highly aqueous environment, these hydrogels will absorb more water, transform from gel to sol, and lose the designed mechanical properties. New insights into the self-assembly of these materials have resulted in new PLA-PEO-PLA gels with novel structural and mechanical properties. Here, we summarize our recent efforts to understand these novel hydrogels and control their mechanical properties. This is highlighted by a new approach in which the system is allowed to self-assemble and then it is covalently cross-linked to capture this self-assembled architecture. This produces hydrogels with permanent cross-links and allows their mechanical properties to be studied in much more detail.

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Stereoisomeric effect on in vitro drug release from injectable poly(lactic acid co castor oil) polyesters

Sokolsky-Papkov

Domb

2008

Polymers for Advanced Techs

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A systematic study on the influence of lactic acid (LA) conformation on polyester properties, degradation, and drug release profiles is reported. Copolyesters based on L‐ or DL‐LA and castor oil (CO) (triglyceride of ricinoleic acid (RA)) were synthesized by melt condensation. Two feed ratios of LA to CO were used. Copolymers with feed ratio of 60:40 and 50:50 LA to CO were synthesized. P(LA/CO)s 60:40 and 50:50 had weight average molecular weights (Mw) of 4700 and 3700, respectively. All polymers are viscous liquids at room temperature. Copolymer composition and LA conformation had direct effect on polymer properties, degradation rate, and drug release profile. Increase in CO content (hydrophobisity) decreased the degradation and release rates of the polymers. Effect of sample size was also different for all polymers. Choosing polymer composition and LA conformation it is possible to choose desired release profile for the tested drug. Copyright © 2008 John Wiley & Sons, Ltd.

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Controlling Hydrogel Properties by Crystallization of Hydrophobic Domains

Cited by 54 publications

References 30 publications

Tuning the gelation of thermoresponsive gels

Tuning the gelation of thermoresponsive gels

PLA–PEO–PLA Hydrogels and Their Mechanical Properties

Stereoisomeric effect on in vitro drug release from injectable poly(lactic acid co castor oil) polyesters

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