Optical chiral metamaterials have recently attracted considerable attention because they offer new and exciting opportunities for fundamental research and practical applications. Through pragmatic designs, the chiroptical response of chiral metamaterials can be several orders of magnitude higher than that of natural chiral materials. Meanwhile, the local chiral fields can be enhanced by plasmonic resonances to drive a wide range of physical and chemical processes in both linear and nonlinear regimes. In this review, we will discuss the fundamental principles of chiral metamaterials, various optical chiral metamaterials realized by different nanofabrication approaches, and the applications and future prospects of this emerging field.