Controlling dielectric loss of biodegradable black phosphorus nanosheets by iron-ion-modification for imaging-guided microwave thermoacoustic therapy

Chen, Xiaoyu; Zhang, Shanxiang; Liu, Jiaqian; Ren, Mingyang; Liang, Guohai; Qin, Huan

doi:10.1016/j.biomaterials.2022.121662

Cited by 11 publications

(10 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microwave can also activate the nanomaterials to generate nanobubbles or local toxic molecules in the targeted biological cells; and thereby TA effect has potential application as non-invasive medical therapy technology. Chen et al proposed to control the dielectric loss of biodegradable black phosphorus (BP) nanosheets for imaging-guided microwave TA therapy (Figure 7b) [37]. Iron ions adsorbed with the lone pair electrons of BP, increasing the permanent electric dipole.…”

Section: Bioimaging and Therapymentioning

confidence: 99%

“…Chen et al. proposed to control the dielectric loss of biodegradable black phosphorus (BP) nanosheets for imaging‐guided microwave TA therapy (Figure 7b) [37]. Iron ions adsorbed with the lone pair electrons of BP, increasing the permanent electric dipole.…”

Section: Dielectrics Materials In Biologymentioning

confidence: 99%

Section: Dielectrics Materials In Biologymentioning

confidence: 99%

See 2 more Smart Citations

Dielectric, piezoelectric, and ferroelectric nanomaterials in the biomedical applications

Wang,

Huang,

Zhang

et al. 2023

IET Nanodielectrics

View full text Add to dashboard Cite

We have witnessed the flourish of bioelectronics, brain–computer interface, and brain science programme in recent decades. In this review, the up‐to‐date advances of dielectric, piezoelectric, and ferroelectric nanomaterials in the biomedical applications are summarised. Biomolecular detection methods have been developed, including dielectric‐gated field‐effect transistor, dielectrophoresis, non‐linear dielectric response, and optical tweezer. Endogenous bioelectricity is a crucial in cell proliferation, migration, differentiation, intracellular communication, neuronal activity, tissue growth. Piezoelectric and ferroelectric materials can be utilised as energy transducer to monitor physiological signal, such as blood pressure or respiration, and directly stimulate cell differentiation, neuronal regeneration, tissue repairment etc. They can also catalyse the electrochemical reaction of organisms through piezoelectricity. The intrinsic relevance between neuronal and ferroelectric polarisation signals inspires the application of the ferroelectrics in the modern intelligent bioelectronics like the artificial retina.

show abstract

Section: Bioimaging and Therapymentioning

confidence: 99%

Section: Dielectrics Materials In Biologymentioning

confidence: 99%

See 1 more Smart Citation

Dielectric, piezoelectric, and ferroelectric nanomaterials in the biomedical applications

Wang,

Huang,

Zhang

et al. 2023

IET Nanodielectrics

View full text Add to dashboard Cite

show abstract

“…22 With MW irradiation , BPNs can absorb electromagnetic waves and convert into thermal energy through dielectric loss. 23 BPNs have good biocompatibility and biodegradability, through which they can degrade into nontoxic phosphate salts in vivo. Encapsulating BPNs into bone repair scaffolds can degrade to PO 4 3− at the site of bone damage and capture existing calcium ions in the body to promote biomineralization of bone defect tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Black phosphorus nanosheets (BPNs), a kind of dielectric material, are exfoliated from black phosphorus (BP) . With MW irradiation , BPNs can absorb electromagnetic waves and convert into thermal energy through dielectric loss . BPNs have good biocompatibility and biodegradability, through which they can degrade into nontoxic phosphate salts in vivo .…”

Section: Introductionmentioning

confidence: 99%

Dielectric and Magnetic Composites of Fe₃O₄@APNs for Superior Microwave Thermal Effect

Zhan,

Wen,

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

As for the deep tissue infections of chronic osteomyelitis, antibiotics are hard to deliver into the infected bone tissue, which makes it difficult to be cured completely in clinic. Microwave has strong penetration, and the medium can produce a good bactericidal effect through the microwave thermal effect (MTE). Here, a new microwave sensitizer (Fe 3 O 4 @APNs) was prepared and evaluated. Black phosphorus nanosheets modified with phytic acid dodecasodium (APNs) were fabricated by a liquid-phase exfoliation method that exhibited good water oxygen stability. A complex with Fe 3 O 4 compound and APNs (Fe 3 O 4 @APNs) was formed by an ultrasonic mixing process, which showed excellent MTE (quickly increased to 53.5 °C in 5 min at 2.45 GHz, 10 W/cm 2 ) via dielectric versus magnetic loss (reflect loss value of −5.94 dB at 2.45 GHz). The Fe 3 O 4 @APNs microwave sensitizer developed in this study has an outstanding in vitro antibacterial effect and might show promise for the treatment of chronic osteomyelitis enabled by local tissue heating via the MTE.

show abstract

Targeting Nanomotor with Near‐Infrared/Ultrasound Triggered‐Transformation for Polystage‐Propelled Cascade Thrombolysis and Multimodal Imaging Diagnosis

Ruan,

Chen,

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Nowadays, cardiovascular and cerebrovascular diseases caused by venous thromboembolism become main causes of mortality around the world. The current thrombolytic strategies in clinics are confined primarily due to poor penetration of nanoplatforms, limited thrombolytic efficiency, and extremely‐low imaging accuracy. Herein, a novel nanomotor (NM) is engineered by combining iron oxide/perfluorohexane (PFH)/urokinase (UK) into liposome nanovesicle, which exhibits near‐infrared/ultrasound (NIR/US) triggered transformation, achieves non‐invasive vein thrombolysis, and realizes multimodal imaging diagnosis altogether. Interestingly, a three‐step propelled cascade thrombolytic therapy is revealed from such intelligent NM. First, the NM is effectively herded at the thrombus site under guidance of a magnetic field. Afterwards, stimulations of NIR/US propel phase transition of PFH, which intensifies penetration of the NM toward deep thrombus dependent on cavitation effect. Ultimately, UK is released from the collapsed NM and achieves pharmaceutical thrombolysis in a synergistic way. After an intravenous injection of NM in vivo, the whole thrombolytic process is monitored in real‐time through multimodal photoacoustic, ultrasonic, and color Doppler ultrasonic imagings. Overall, such advanced nanoplatform provides a brand‐new strategy for time‐critical vein thrombolytic therapy through efficient thrombolysis and multimodal imaging diagnosis.

show abstract

Controlling dielectric loss of biodegradable black phosphorus nanosheets by iron-ion-modification for imaging-guided microwave thermoacoustic therapy

Cited by 11 publications

References 53 publications

Dielectric, piezoelectric, and ferroelectric nanomaterials in the biomedical applications

Dielectric, piezoelectric, and ferroelectric nanomaterials in the biomedical applications

Dielectric and Magnetic Composites of Fe₃O₄@APNs for Superior Microwave Thermal Effect

Targeting Nanomotor with Near‐Infrared/Ultrasound Triggered‐Transformation for Polystage‐Propelled Cascade Thrombolysis and Multimodal Imaging Diagnosis

Contact Info

Product

Resources

About

Controlling dielectric loss of biodegradable black phosphorus nanosheets by iron-ion-modification for imaging-guided microwave thermoacoustic therapy

Cited by 11 publications

References 53 publications

Dielectric, piezoelectric, and ferroelectric nanomaterials in the biomedical applications

Dielectric, piezoelectric, and ferroelectric nanomaterials in the biomedical applications

Dielectric and Magnetic Composites of Fe3O4@APNs for Superior Microwave Thermal Effect

Targeting Nanomotor with Near‐Infrared/Ultrasound Triggered‐Transformation for Polystage‐Propelled Cascade Thrombolysis and Multimodal Imaging Diagnosis

Contact Info

Product

Resources

About

Dielectric and Magnetic Composites of Fe₃O₄@APNs for Superior Microwave Thermal Effect