Controlling diabetes with the aid of medicinal herbs: a critical compilation of a decade of research

Siddiqui, Shahida Anusha; Khan, Sipper; Wani, Sajad Ahmad

doi:10.1080/10408398.2022.2103088

Cited by 6 publications

(4 citation statements)

References 108 publications

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“…The increasing prevalence of type 2 diabetes, insulin resistance and obesity has become a public health problem and increased the economic burden for the global healthcare system [ 30 ]. The control and treatment of type 2 diabetes is imminent, and there are quite a few international guidelines and institutions for the improvement of diabetes [ 31 , 32 , 33 ]. The efficacy of medicinal herbs and medical plant compounds on T2DM treatment have been highlighted in multiple studies [ 34 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology Analysis, Molecular Docking Integrated Experimental Verification Reveal the Mechanism of Gynostemma pentaphyllum in the Treatment of Type II Diabetes by Regulating the IRS1/PI3K/Akt Signaling Pathway

Yang,

Zhao,

et al. 2024

CIMB

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Gynostemma pentaphyllum (Thunb.) Makino (GP), a plant with homology of medicine and food, as a traditional Chinese medicine, possesses promising biological activities in the prevention and treatment of type 2 diabetes mellitus (T2DM). However, the material basis and the mechanism of action of GP in the treatment of T2DM have not been fully elucidated. This study aimed to clarify the active components, potential targets and signaling pathways of GP in treating T2DM. The chemical ingredients of GP were collected by combining UPLC-HRMS analysis and literature research. Network pharmacology revealed that GP had 32 components and 326 potential targets in treating T2DM. The results showed that GP affected T2DM by mediating the insulin resistance signaling pathway, PI3K/Akt signaling pathway and FoxO1 signaling pathway, which had a close relationship with T2DM. Molecular docking results showed that STAT3, PIK3CA, AKT1, EGFR, VEGFA and INSR had high affinity with the active compounds of GP. In vitro, GP extracts obviously increased the glucose uptake and glucose consumption in IR-HepG2 cells. GP extracts increased the levels of PI3K, p-AKT, p-GSK3β and p-FoxO1 and decreased the expression of p-IRS1, p-GS, PEPCK and G6Pase, which indicated that GP could promote glycogen synthesis and inhibit gluconeogenesis by regulating the IRS1/PI3K/Akt signaling pathway. The results demonstrated that GP could improve insulin resistance by promoting glucose uptake and glycogen synthesis and inhibiting gluconeogenesis through regulating the IRS1/PI3K/Akt signaling pathway, which might be a potential alternative therapy for T2DM.

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Section: Discussionmentioning

confidence: 99%

Network Pharmacology Analysis, Molecular Docking Integrated Experimental Verification Reveal the Mechanism of Gynostemma pentaphyllum in the Treatment of Type II Diabetes by Regulating the IRS1/PI3K/Akt Signaling Pathway

Yang,

Zhao,

et al. 2024

CIMB

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“…For pharmaceutical companies, this is a chance to increase profits and gain new market shares. From the point of view of medicine, generics have a similar composition, and while preserving the properties of the original drugs, their cost is significantly lower, which means that more patients will be able to receive the necessary treatment [18][19][20].…”

Section: The State Of the Russian Pharmaceutical Market From The Poin...mentioning

confidence: 99%

Socio-Demographic and Economic Factors of the Pharmaceutical Market Development in Russia

Ismailov¹,

Lazareva²,

Родионова³

et al. 2022

Pharmacophore

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“…In addition, orthorexia is supposed to be introduced into ICD 10. Orthorexia is a disordered eating, which is characterized by an obsessive desire for healthy and proper nutrition, which leads to significant restrictions in the choice of food [8][9][10][11].…”

Section: International Classifier Of Diseasesmentioning

confidence: 99%

Eating Disorders in Accordance with the International Classification of Diseases

Salgirieva¹,

Stepanyan²,

Voitleva³

et al. 2022

Pharmacophore

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In recent years, there have been more and more cases of eating disorders in the world. Such cases are especially common among teenagers and young people. The fashion for slender bodies and attempts to be like their idol often force teenage girls around the world to go on strict diets, exhaust themselves with heavy workouts, and use medicines for weight loss. On the other hand, constant stress and bullying, misunderstandings in the family -these factors lead to uncontrolled appetite and attempts to "jam" stress, which subsequently exerts even greater psychological pressure on a person. The International Classification of Diseases of the 10th revision identifies the following types of eating disorders: anorexia nervosa, bulimia nervosa, compulsive overeating, vomiting associated with various psychological disorders, etc. Eating disorders affect at least 9% of the world's population and often end in death. Unfortunately, people rarely turn to specialists at the first symptoms that allow them to diagnose eating disorders, so most often correction requires a whole range of measures. Several specialists are necessarily involved in the process, including a psychiatrist. The article presents a description and symptoms of the main types of eating disorders describes in detail the principles of psychotherapy for these diseases and also presents some methods of psychotherapeutic assistance for eating disorders.

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Controlling diabetes with the aid of medicinal herbs: a critical compilation of a decade of research

Cited by 6 publications

References 108 publications

Network Pharmacology Analysis, Molecular Docking Integrated Experimental Verification Reveal the Mechanism of Gynostemma pentaphyllum in the Treatment of Type II Diabetes by Regulating the IRS1/PI3K/Akt Signaling Pathway

Network Pharmacology Analysis, Molecular Docking Integrated Experimental Verification Reveal the Mechanism of Gynostemma pentaphyllum in the Treatment of Type II Diabetes by Regulating the IRS1/PI3K/Akt Signaling Pathway

Socio-Demographic and Economic Factors of the Pharmaceutical Market Development in Russia

Eating Disorders in Accordance with the International Classification of Diseases

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