Controlling catalyst activity, chemoselectivity and stereoselectivity with the mechanical bond

Heard, Andrew W.; Suárez, Jorge Meijide; Goldup, Stephen M.

doi:10.1038/s41570-021-00348-4

Cited by 79 publications

(56 citation statements)

References 102 publications

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“…Besides the use of new types of interlocked struts, one of the main objectives is to increase the structural complexity of the MIM ligands to prepare metal-organic materials having enhanced properties. For example, the utilization of interlocked catalysts [159][160][161][162][163] as ligands of MOFs would open new possibilities in heterogeneous catalysis. 11 Very likely, recent developments on the preparation of enantiopure MIMs incorporating novel chirality motifs [164][165][166] would allow significant advances in the construction of coherent chiral MOFs which can be employed in asymmetric catalysis.…”

Section: Discussionmentioning

confidence: 99%

Mechanically interlocked molecules in metal–organic frameworks

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Mechanically interlocked molecules in metal–organic frameworks

et al. 2022

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“…In the last decades the synthesis and application of mechanically interlocked molecules (MIMs), such as catenanes and rotaxanes, has gained more and more attention [ 1 – 4 ]. MIMs offer conceptually new possibilities through their unique structure, with applications as molecular switches, muscles, and motors [ 5 – 11 ], as novel materials [ 12 ], as medically active compounds [ 13 – 14 ], as catalysts [ 15 – 19 ], as chemosensors [ 20 – 24 ], and many more [ 25 ]. In view of their template-based synthesis and the importance of noncovalent interactions between the subcomponents, MIMs have established themselves as an important subdiscipline of supramolecular chemistry.…”

Section: Introductionmentioning

confidence: 99%

BINOL as a chiral element in mechanically interlocked molecules

Krajnc¹,

Niemeyer²

2022

Beilstein J. Org. Chem.

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In this minireview we present the use of the axially chiral 1,1'-binaphthyl-2,2'-diol (BINOL) unit as a stereogenic element in mechanically interlocked molecules (MIMs). We describe the synthesis and properties of such BINOL-based chiral MIMs, together with their use in further diastereoselective modifications, their application in asymmetric catalysis, and their use in stereoselective chemosensing. Given the growing importance of mechanically interlocked molecules and the key advantages of the privileged chiral BINOL backbone, we believe that this research area will continue to grow and deliver many useful applications in the future.

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“…Different research groups have disclosed different mechanized systems as either organocatalysts 2 or ligands in metal-catalysed transformations, 3 including their use in asymmetric processes. 4,5 In rotaxane-based catalysts, the possibility of controlling the ring position along the thread by the application of an input enables the design of switchable rotaxane-based catalysts. The bulky macrocycle conceals or exposes the active sites placed at the thread, altering their catalytic capability in terms of activity (ON/OFF), 6 enantio- or diastereoselectivity switching 7 or election between activation modes.…”

Section: Introductionmentioning

confidence: 99%