Controlling a Mivacurium Infusion Using an Artificial Neural Network

Geldner, Goetz; Schwarz, Urs; Romeiser, Hans-Joachim; Lendel, M.; Ruoff, Marcel; Georgieff, Michael

doi:10.1097/00000542-199809170-00029

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1999

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“…Ein neuronales Netzwerk[4,12] kann sich nach einer Trainingsphase sehr rasch auch auf die Bedürfnisse anderer unbekannter Patienten anpassen und wäre somit geeignet für die Regelung einer Mivacuriuminfusion.Ziel dieser Studie war es, den Einsatz eines neuronalen Netzwerks[3,4,12] (NNW) zur Regelung einer Mivacuriuminfusion[13] zu erproben und danach das somit entwickelte System klinisch zu validieren. Bisher konnte nur eine Regelung, basierend auf ein Kompartimentmodell, eine Mivacuriuminfusion regeln.…”

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Entwicklung eines neuen Closed-Loop Systems Regelung einer Mivacurium-induzierten neuromuskulären Blockade

et al. 1999

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A closed-loop system for control of a mivacurium infusion could be established. The system proofed to be reliable for a closed-loop infusion of mivacurium in order to maintain a predefined degree of neuromuscular blockade of 95% during routine surgery. The performance of the described controller is comparable to all recent attempts and could therefore be useful for scientific studies. It should be further validated and established for other muscle relaxants, as well.

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