A HVAC (Heat Ventilation Air Condition) system of passenger seat in autonomous bus is used for heating and cooling of the seat. The compressor of the HVAC system generates the operating noise, and the noise makes passengers annoyance. Frequency spectrum of the compressor noise composes of operating frequency and its harmonics components. Frequency band of operating frequency is low, and that of harmonic frequencies is high. Active noise control (ANC) has been used for reduction of low frequency noise while a passive method using absorption material has been used for attenuation of high frequency harmonic noise. However, some part of harmonic components at low frequency band among harmonic components is not able to reduce by using absorption materials. In this paper, a new ANC method is proposed for the reduction of noise level of low frequency harmonic components based on harmonic flited x-LMS (HFX-LMS) algorithm. The novel method is successfully applied to the noise control of compressor of HVAC system of passenger seat in autonomous bus.