Controlled Trial of the Effect of Cinnamon Extract on Helicobacter pylori

Abstract

We concluded that cinnamon extract, at a concentration of 80 mg /day as a single agent, is ineffective in eradicating H. pylori. Combination of cinnamon with other antimicrobials, or cinnamon extract at a higher concentration, however, may prove useful.

Anti-inflammatory Effect of Cinnamaldehyde in Helicobacter pylori Induced Gastric Inflammation

“…20) However, controlled clinical trials of Cinnamon extracts had failed to eradicate H. pylori, and few other herbs were only able to improve H. pyloriassociated symptoms. 41) Hence, in our view, herbs such as C. cassia might have more potential as an anti-inflammatory rather than anti-H. pylori agent. In this study we report nonbactericidal concentration of CM (≤250 µM).…”

Immunomodulatory activity ofCinnamomum zeylanicumbark

“…Apart from its use as spice, it is shown to possess a wide range of pharmacological effects such as antidiabetic (Khan et al, 2003), hypolipidemic (Kamath et al, 2003;Usta et al, 2003), antibacterial (Nir et al, 2000), and antifungal activities (Ranasinghe et al, 2002). Further, it is widely believed in India that cinnamon is a potent immune system booster and consumption of cinnamon with honey strengthens the immune system.…”

In Vitro Activity of Olive Oil Polyphenols against Helicobacter pylori

“…However, in vivo studies with garlic (19), jalapeño peppers (20), cinnamon extract (21), broccoli (22), and cranberry juice (23) failed to eradicate H. pylori infection in spite of the wellreported antibacterial data obtained from in vitro experiments. With this concern in mind, researchers have recommended the consumption of these natural foods as chemopreventive agents (6) or in combination with antibiotics to eradicate the bacterial infection (24).…”