CONTROLLED TRIAL of INTRAVENOUS AMINOPHYLLINE IN ACUTE CEREBRAL INFARCTION

Immunoinhibitory factors in the sera of stroke patients were studied by an analysis of their capacity to influence the in vitro proliferative response of T cells. The evidence was obtained that the sera from stroke patients exhibited inhibitory activity on T cell proliferation. Although the nature of these inhibitory factors was not analyzed, it was clearly shown that their activity correlated with the degree of neurological defects, indicating that their determination may be of some prognostic value.

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“…Neurological status o f our patients was established by the iden tification o f the neurological score [according to Geismar et al, 1976] …”

Section: Methodsmentioning

confidence: 99%

Serum Immunoinhibitory Factors in Stroke Patients

Kostić¹,

Mostarica-Stojković

Ramić

et al. 1988

Eur Neurol

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“…The immediate improvement of the signs of local cerebral dysfunction, which can be observed after an intravenous bolus injection of aminophylline in some patients suffering from acute stroke (Schiemert 1951 ;Schmidt-Voight 1951 ;Mainzer 1953;Weihs 1954;Olivarius 1970;Geismar et al 1976), may be ascribed to the vasoconstrictory effect of theophylline on non-ischemic brain vasculature thus causing a n "inverse steal" phenomenon (Skinhsj & Paulson 1970).…”

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confidence: 99%

Pharmacokinetics of Theophylline in Ten Elderly Patients

Nielsen‐Kudsk

Magnussen

Jakobsen

1978

Acta Pharmacologica et Toxicologica

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Abstraci:The two-compartment pharmacokinetics of theophylline in ten hospitalized elderly patients with apparently normal renal, hepatic and cardiopulmonary functions was investigated after intravenous administration of the drug. Nine patients suffered from slight hemiparesis and one from Parkinson's disease. Biological theophylline half-lives of 5.49.0 hours and plasma clearence values of 2842 ml kg-'hr-' were found. The apparent volumes of distribution during the P-phase, V,,, were 0.334.43 1 kg-'. It is concluded that a therapeutic concentration of about 10 pg theophylline per ml serum could be established in the investigated group of elderly patients following an intravenous initial loading dose of 3.7 mg theophylline per kg followed by a continuous infusion of 0.35 mg per kg body weight per hour. In the therapeutic use of theophylline monitoring of the serum theophylline concentration is generally advised because of the elsewhere reported variability in the biological half-life of the compound.

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“…Neu rological status both in controls and patients with cerebral infarction was established by the identifica tion of the neurological score [9] upon admission to the hospital; according to this procedure, the lowest value of the score was 4 and the highest 17 points.…”

Section: Methodsmentioning

confidence: 99%

Cerebrospinal Fluid Prostaglandin F<sub>2α</sub> in Stroke Patients: No Relationship to the Degree of Neurological Deficit

Kostić¹,

Djuričić²,

Mršulja³

1984

Eur Neurol

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The concentration of prostaglandin F_2α (PGF_2α) was measured in cerebrospinal fluid (CSF) of 50 patients with recent stroke divided into three groups in respect to the time (up to 24 h) that expired between cerebrovascular insult and CSF sampling. 10 of the additionally studied persons were neurologically normal (control group). None of the investigated subjects were undergoing any therapy at the time of CSF sampling. The estimation of the neurological score revealed that the stroke patients suffered from acute cerebral ischemic attacks of varying severity. No relationship between the CSF PGF_2α level and neurological status was found. Within the first 4 h after the stroke a marked increase in PGF_2α was found, afterwards being diminished but still enhanced in comparison to the controls.

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CONTROLLED TRIAL of INTRAVENOUS AMINOPHYLLINE IN ACUTE CEREBRAL INFARCTION

Cited by 28 publications

References 7 publications

Serum Immunoinhibitory Factors in Stroke Patients

Serum Immunoinhibitory Factors in Stroke Patients

Pharmacokinetics of Theophylline in Ten Elderly Patients

Cerebrospinal Fluid Prostaglandin F<sub>2α</sub> in Stroke Patients: No Relationship to the Degree of Neurological Deficit

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