Controlled study of withdrawal symptoms and rebound anxiety after six week course of diazepam for generalised anxiety.

Power, Kevin; Jerrom, D. W. A.; Simpson, Richard; Mitchell, M. J.

doi:10.1136/bmj.290.6477.1246

Cited by 73 publications

(22 citation statements)

References 13 publications

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“…These medications were shown to have undesirable effects including amnesia, ataxia, tiredness, nausea, hypotension, leucopenia, hostility, confusion and depression [34], tolerance and dependence [35,36]. Benzodiazepines are still in use today for the treatment of insomnia.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Bovine Alpha S1-Casein Tryptic Hydrolysate (CTH) on Sleep Disorder in Japanese General Population

Saint-Hilaire¹,

Messaoudi²,

Desor³

et al. 2009

TOSLPJ

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This study describes the effect of bovine alpha-S1 casein tryptic hydrolysate (CTH) in a representative sample of day-time workers from the general population of Japan with the occurrence of insomnia during the preceding six months. To investigate this issue, 32 subjects, aged between 25 and 40 years, were examined for the subjective sleep quality using the Japanese Pittsburg Sleep Quality Index (PSQI-J).CTH significantly improves the PSQI total score of the treated subjects. It particularly improves the sleep quality after two weeks of treatment, decreases the sleep latency and the daytime dysfunction after four weeks of treatment.Given the antistress properties of CTH, it seems possible to relate the detected improvement of sleep aspects to a reduction of stress following its' chronic administration.In conclusion, being given its beneficial effects and its absence of negative side effects, it would be advantageous to use the CTH to improve chronic insomnia in the Japanese general population. However, further studies will be necessary in order to clarify the essential aspect of CTH properties in the sleep problems.

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Section: Introductionmentioning

confidence: 99%

Effects of a Bovine Alpha S1-Casein Tryptic Hydrolysate (CTH) on Sleep Disorder in Japanese General Population

Saint-Hilaire¹,

Messaoudi²,

Desor³

et al. 2009

TOSLPJ

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show abstract

“…D'ailleurs, un syndrome de sevrage peut apparaître après un traitement continue de 6 semaines avec une benzodiazépine (Power et al, 1985). De plus, les études montrent que l'usage d'une benzodiazépine pendant plus de huit mois à des doses élevées est en relation avec la sévérité des symptômes de sevrage et l'un des facteurs de risque favorisant l'échec du sevrage (Rickels et al, 1983 ;Rickels et al, 1990 ;Murphy et Tyrer, 1991).…”

Section: Durée Du Traitement En Coursunclassified

Conseils cliniques pour faciliter le sevrage des benzodiazépines

Landry¹,

Mainguy²

2004

smq

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Résumé Cet article résume une approche clinique visant à faciliter le sevrage des benzodiazépines. Les auteurs soulignent l’importance d’une évaluation médicale afin de préciser les raisons qui ont mené à l’utilisation et au maintien d’un traitement pharmacologique et de bien comprendre les raisons et la motivation du patient voulant cesser sa médication. Lors de cette évaluation, il est important d’informer le patient de cesser la médication graduellement afin de réduire la sévérité des effets secondaires à prévoir durant le sevrage. Une approche par étape où le patient participe activement aux décisions est proposée à la fois pour réduire l’anxiété du patient, mais aussi pour éviter que ce dernier ne prenne des initiatives sans en discuter avec le médecin ce qui irait à l’encontre d’une approche visant à optimiser la réussite du sevrage. Quelques vignettes cliniques sont présentées afin de démontrer les étapes du sevrage, mais aussi pour illustrer des situations où la diminution et même l’arrêt de la médication s’avèrent difficiles.

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“…This is not generally agreed but after stopping regular treatment after four to six weeks there is unequivocal symptomatic change indicative of a withdrawal reaction (Power et al, 1985). Symptoms of withdrawal normally begin within 24 hours of stopping short-acting benzodiazepines and up to six days after stopping a long-acting one.…”

Section: Risksmentioning

confidence: 99%

Pharmacotherapy for anxiety disorders: using the available drugs

Tyrer¹

1997

Adv. psychiatr. treat

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The treatment of anxiety is one of the more contentious issues in therapeutics. It is also one of the most important, as pathological anxiety is such a common symptom in the population. The recent Office of Population Censuses and Surveys survey of psychiatric morbidity indicated that one in eight of all those interviewed had an anxiety disorder of sufficient severity to receive a formal diagnostic label in the week before interview (Meltzer et al, 1994). Clearly, only a proportion of these should be treated with drugs, and selection for pharmacotherapy is one of the more difficult issues in clinical practice. It is a matter of some concern that changes in the National Health Service are increasingly shifting the onus of responsibility for treatment from the psychiatrist to the general practitioner. As a consequence, it behoves both disciplines to keep liaison active, so that best practice can be maintained from whatever source it is being provided.

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Controlled study of withdrawal symptoms and rebound anxiety after six week course of diazepam for generalised anxiety.

Cited by 73 publications

References 13 publications

Effects of a Bovine Alpha S1-Casein Tryptic Hydrolysate (CTH) on Sleep Disorder in Japanese General Population

Effects of a Bovine Alpha S1-Casein Tryptic Hydrolysate (CTH) on Sleep Disorder in Japanese General Population

Conseils cliniques pour faciliter le sevrage des benzodiazépines

Pharmacotherapy for anxiety disorders: using the available drugs

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