Controlled Study of Androgen Therapy in Anemia of Patients on Maintenance Hemodialysis

Hendler, Ernesto D.; Goffinet, John A.; Ross, Stephen C.; Longnecker, Robert E.; Bakovic, Vjera

doi:10.1056/nejm197411142912002

Cited by 93 publications

(26 citation statements)

References 21 publications

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“…The use of androgens in conjunction with replacement iron therapy has been recommended [25,26]. Our studies also support the clinical value of androgen therapy, both with oral and parenteral iron.…”

Section: Discussionsupporting

confidence: 78%

Therapy of Iron Deficiency Anemia in Patients on Maintenance Dialysis

Parker¹,

Izard²,

Maher³

1979

Nephron

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A controlled, prospective study compared the effectiveness of oral ferrous sulfate to intravenous iron dextran, each with and without concurrent intramuscular androgen for therapy of iron deficiency anemia in patients with chronic renal failure treated with maintenance hemodialysis. During the 12-week period of therapy, the patients who received oral ferrous sulfate and androgens showed an increment in their mean hematocrit of 16.3% and those who received oral ferrous sulfate alone had an increase of 8.3%. Patients treated with intravenous iron dextran and androgens showed an increment in their mean hematocrit of 9.4% and those given iron dextran alone showed an increase of 3.5%. Serum ferritin levels increased with iron repletion but correlated inversely with the erythropoietic response. The serum ferritin assay provides a simple and reliable method to demonstrate iron repletion, and oral ferrous sulfate is the preferred method of iron repletion in compliant patients.

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Section: Discussionsupporting

confidence: 78%

Therapy of Iron Deficiency Anemia in Patients on Maintenance Dialysis

Parker¹,

Izard²,

Maher³

1979

Nephron

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“…These investigators conclude that more efficient hemodialysis with proper supplementation of iron and protein-rich foods and selective use of androgens was a much more successful therapy in their studies of 129 pa tients with anemia of terminal renal failure. Androgens have been widely used for the treatment of anemia of renal disease with some definite increases in red cell mass [36,77] but their deleterious side effects makes them less desirable for the treatment of this anemia. Some investigators have found that the responsiveness of the bone marrow of uremic animals [8] and patients [18,72] to erythropoietin is re duced.…”

Section: Clinical Implications Of Ep For the Treatment Of The Anemia mentioning

confidence: 99%

Mechanism of the Anemia of Chronic Renal Failure

Fisher¹

1980

Nephron

105

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“…Therapy with 17a-alkylated androgens [4], testosterone esters [5][6][7] and non-17a-alkylated androgens [8] appears to be efficacious for the treatment of the anemia of renal insufficiency in non iron-deficient patients. These steroids stimulate erythropoietin production in man and animals [4,9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Nandrolone Decanoate on the Anemia of Chronic Hemodialysis Patients

Buchwald¹,

Argyres²,

Easterling³

et al. 1977

Nephron

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A double-blind cross-over study was conducted on 21 patients on maintenance hemodialysis to determine if changes in serum erythropoietin level, packed cell volume, red cell mass, hemoglobin concentration and 2,3-diphosphoglycerate content of red cells follow administration of nandrolone decanoate. There was a rise in mean serum erythropoietin level, packed cell volume, red cell mass and hemoglobin concentration. No alteration in mean 2,3-diphosphoglycerate content of red blood cells was found.

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Controlled Study of Androgen Therapy in Anemia of Patients on Maintenance Hemodialysis

Cited by 93 publications

References 21 publications

Therapy of Iron Deficiency Anemia in Patients on Maintenance Dialysis

Therapy of Iron Deficiency Anemia in Patients on Maintenance Dialysis

Mechanism of the Anemia of Chronic Renal Failure

Effect of Nandrolone Decanoate on the Anemia of Chronic Hemodialysis Patients

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