“…Future progress in this field, linked to the bioinformatic analysis of the growing number of reported microRNAs and long non-coding RNAs, could help better identify high-risk patients 13 . Finally, the availability of expert healthcare professionals to ensure not only adherence regarding selection and data collection but also to provide comprehensive smoking cessation counselling, adequate patient information and care when uncertainty is generated, as well as expertise in diagnosis and treatment when early lung cancer is detected, also determine the quality of a screening program 14 .…”