Controlled Self-Assembly of a Close-Packed Gold Octahedra Array for SERS Sensing Exosomal MicroRNAs

Kang, Tuli; Zhu, Jingtian; Luo, Xiaojun; Jia, Wenyu; Wu, Ping; Cai, Chenxin

doi:10.1021/acs.analchem.0c04561

Cited by 54 publications

(42 citation statements)

References 51 publications

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“…Zhang et al achieved controlled self-assembly of gold nanoparticles into a 3D hotspot structure by regulating the addition of halogen ions [ 64 ]. Kang et al implemented a bottom-up approach to achieve self-assembly of a close-packed gold octahedral array that exhibited an intense electric field at the edges and sharp corners of the nanostructure [ 65 ]. Ye et al fabricated densely-packed, 2D arrays of plasmonic nanoparticles via nanoparticle self-assembly at the water-oil interface [ 66 ].…”

Section: Applications Of Sers In Drug Detectionmentioning

confidence: 99%

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection

Azimi¹,

Docoslis²

2022

Sensors

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The rapid increase in illicit drug use and its adverse health effects and socio-economic consequences have reached alarming proportions in recent years. Surface-enhanced Raman scattering (SERS) has emerged as a highly sensitive analytical tool for the detection of low dosages of drugs in liquid and solid samples. In the present article, we review the state-of-the-art use of SERS for chemical analysis of illicit drugs in aqueous and complex biological samples, including saliva, urine, and blood. We also include a review of the types of SERS substrates used for this purpose, pointing out recent advancements in substrate fabrication towards quantitative and qualitative detection of illicit drugs. Finally, we conclude by providing our perspective on the field of SERS-based drug detection, including presently faced challenges. Overall, our review provides evidence of the strong potential of SERS to establish itself as both a laboratory and in situ analytical method for fast and sensitive drug detection and identification.

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Section: Applications Of Sers In Drug Detectionmentioning

confidence: 99%

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection

Azimi¹,

Docoslis²

2022

Sensors

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“…Where the gold octahedra in the array stand uniformly on their triangular faces, significantly improving detection sensitivity and uniformity. This model enables let-7a detection with single-base specificity in the presence of a target by detecting the SERS intensity change caused by the conversion of DNA from a hairpin structure to a double-stranded body ( Kang et al, 2021 ). Chen et al (2020) A novel exosome/metal nanohybrid was constructed.…”

Section: Sers Technology For Exosome Detectionmentioning

confidence: 99%

Advances in the Application of Exosomes Identification Using Surface-Enhanced Raman Spectroscopy for the Early Detection of Cancers

Yang

Jia

2022

Front. Bioeng. Biotechnol.

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Exosomes are small nanoscale vesicles with a double-layered lipid membrane structure secreted by cells, and almost all types of cells can secrete exosomes. Exosomes carry a variety of biologically active contents such as nucleic acids and proteins, and play an important role not only in intercellular information exchange and signal transduction, but also in various pathophysiological processes in the human body. Surface-enhanced Raman Spectroscopy (SERS) uses light to interact with nanostructured materials such as gold and silver to produce a strong surface plasmon resonance effect, which can significantly enhance the Raman signal of molecules adsorbed on the surface of nanostructures to obtain a rich fingerprint of the sample itself or Raman probe molecules with ultra-sensitivity. The unique advantages of SERS, such as non-invasive and high sensitivity, good selectivity, fast analysis speed, and low water interference, make it a promising technology for life science and clinical testing applications. In this paper, we briefly introduce exosomes and the current main detection methods. We also describe the basic principles of SERS and the progress of the application of unlabeled and labeled SERS in exosome detection. This paper also summarizes the value of SERS-based exosome assays for early tumor diagnosis.

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“…Remarkable biosensing performance can be obtained by using 2D highly packed lattices of polyhedral nanoparticles although their EF SERS values are lower than that achieved with 3D architectures. Kang et al [132] reported a novel and highperformance SERS-based sensing platform for a quantitative measurement of let-7a miRNAs in MCF-7 exosomes. The substrate consisted of an array of close-packed and ordered Au octahedra (Figure 10a-1), whose sharp edges are ideal for SERS enhancement.…”

Section: Sers-based Biosensingmentioning

confidence: 99%

“…Adapted with permission. [132] Copyright 2021, American Chemical Society. b-1) Working scheme of the Au-Ag nanorod SERS platform (top panel) and SEM images before (bottom-left panel) and after (bottom-right panel) the modification with Au, b-2) Raman spectra of human IgGs on different SERS substates, and b-3) calibration curve for the detection of human IgGs obtained by evaluating the Raman intensity at 1080 cm −1 .…”

Section: Seira-based Biosensingmentioning

confidence: 99%

“…a-1) TEM image of the close-packed array of Au octahedra, a-2) sketch (top-left panel) and SEM image (bottom-left panel) of the array and electric field enhancement at the Au/water interface under excitation at 633 nm (right panel), a-3) SERS spectrum and no-enhanced Raman spectrum of a 4-mercaptobenzoic acid solution, and a-4) calibration curve for the detection of let-7a miRNAs in MCF-7 exosomes. Adapted with permission [132]. Copyright 2021, American Chemical Society.…”

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Nanostructured Surfaces as Plasmonic Biosensors: A Review

Minopoli

Acunzo

Ventura

et al. 2021

Adv Materials Inter

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are the main features exhibited by metal nanostructures thereby opening up the possibility for manipulating light at nanometric scale, well below the diffraction limit. [1] So far, the tremendous potentialities of the plasmon-related effects have been already represented a breakthrough in many application fields such as cancer treatment, [2] ultrasensitive molecule detection, [3] integrated circuitry, [4] quantum optics, [5] optoelectronics, [6] photovoltaics. [7] Several types of plasmonic nanostructures are being conceived these days aiming at improving the performance of plasmon-based devices. [8,9] At the basis of the nonpropagating plasmon phenomena there is the localized surface plasmon resonance (LSPR), namely, the collective oscillation of the conduction electron cloud against the metal core. [10] The plasmonic properties of metal nanomaterials strongly depend on the nanostructure geometry, arrangement, and environment. For instance, exotic nanostructures such as nanocages, nanoscaffolds, and bow-tie nanoantennas exhibit higher field enhancement than conventional nanoparticles with smooth surfaces thereby representing a considerable advantage in applications relying on signal amplification such as surface-enhanced Raman spectroscopy (SERS), [11,12] surface-enhanced infrared absorption (SEIRA), [13,14] and plasmon-enhanced fluorescence (PEF). [15,16] In addition, when nanostructures are ordered in periodic arrays, new modes can arise as a result of the near-or far-field coupling among the localized plasmons so as to activate hybrid effects such as coupled LSPR (c-LSPR) [17,18] and surface lattice resonance (SLR), [19][20][21] respectively. Besides, plasmonic properties offered by metamaterials were recently investigated and sparked considerable interest since they demonstrated to offer significantly better performance as compared to metal-based nanostructures in many fields of applications such as biosensing, [22] photonics, [23] photovoltaics, [24] and optoelectronics. [25] Nevertheless, the actual implications are still far-reaching for many scientific and engineering fields due to their complexity and low awareness. [25] Therefore, the possibility to tune the optical response of a nanostructure by tailoring the material, shape, and size, as well as the pattern architecture, is spurring the researchers to explore new approaches, in terms of both nanofabrication and nanoapplications, in order to go beyond the current limits of many techniques.The aim of the present work is to provide a comprehension of this growing field of research and to convey the main features of the nanostructured surfaces to biosensing applications.Conventional laboratory techniques exhibit impressive sensing performance and still constitute an irreplaceable tool in bioanalytics. Nevertheless, high costs, time consumption, and need for well-equipped laboratories and skilled personnel make highly desirable to explore novel strategies to carry out biochemical analyses. In this regard, biosensor-based methods represent a promising appr...

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Controlled Self-Assembly of a Close-Packed Gold Octahedra Array for SERS Sensing Exosomal MicroRNAs

Cited by 54 publications

References 51 publications

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection

Advances in the Application of Exosomes Identification Using Surface-Enhanced Raman Spectroscopy for the Early Detection of Cancers

Nanostructured Surfaces as Plasmonic Biosensors: A Review

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