Controlled Reperfusion Protects Lung Grafts During a Transient Early Increase in Permeability

Bhabra, Moninder; Hopkinson, David; Shaw, Trudi E.; Onwu, Natasha; Hooper, Timothy L.

doi:10.1016/s0003-4975(97)01002-3

Cited by 51 publications

(37 citation statements)

References 18 publications

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“…Primary PH is the most significant risk factor for PGD 11,14,34 . As we pointed out above, the results of a recent meta-analysis showed strong associations between primary PH and mPAP with PGD 8 .…”

Section: Resultsmentioning

confidence: 99%

“…First, they provide further evidence of the pathophysiology of PGD. Second, they might allow an assessment of the effectiveness of new potential treatment strategies, such as the progressive intraoperative reintroduction of pulmonary flow, in patients with a high risk of PGD development in whom these strategies could provide more benefits in terms of pulmonary edema reduction 16,33,34 .…”

Section: Resultsmentioning

confidence: 99%

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Influence of right ventricular function on the development of primary graft dysfunction after lung transplantation

Roca

Rodríguez-Palomares

Sacanell

et al. 2015

The Journal of Heart and Lung Transplantation

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Influence of right ventricular function on the development of primary graft dysfunction after lung transplantation

Roca

Rodríguez-Palomares

Sacanell

et al. 2015

The Journal of Heart and Lung Transplantation

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“…We reported our experience with the perioperative use of ECMO in PPH patients and found it extremely beneficial for initial organ function [3]. Since a significant amount of volume is bypassed by the lung optimal controlled reperfusion [13,14] can be achieved with the additional benefits of non-aggressive ventilation [15]. Additional potential benefits of ECMO over cardiopulmonary bypass are the avoidance of full heparinisation due to the heparin coated cannulas and the potential to prolong the support beyond the operation itself.…”

Section: Discussionmentioning

confidence: 99%

Institutional experience with extracorporeal membrane oxygenation in lung transplantation☆

Aigner

Wisser

Taghavi

et al. 2007

European Journal of Cardio-Thoracic Surgery

212

130

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ECMO is a valuable tool in lung transplantation providing the potential to bridge patients to transplantation, to replace CPB with at least equal results and to overcome severe postoperative complications. Favourable survival rates can be achieved despite the fact that ECMO is used in the more complex patient population undergoing lung transplantation as well as to overcome already established severe complications.

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“…Recently, the use of controlled reperfusion in combination with leukocyte depletion has shown promise as a preventative strategy [49][50][51][52][53][54][55]. LICK et al [56] reported a nonrandomised small series in humans utilising this technique with no reperfusion injury.…”

Section: Reperfusion Injurymentioning

confidence: 99%

Current status of lung transplantation

Lau¹,

Patterson²

2003

European Respiratory Journal

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Two decades have passed since the first successful clinical lung transplant was performed in 1983, and, in the interim, lung transplantation has become the preferred treatment option for a variety of end-stage pulmonary diseases. Remarkable progress has been made in the field through refinement of technique and improved understanding of transplant immunology and microbiology.Unfortunately, donor shortages continue to limit the more widespread application of lung transplantation. In order to address this issue, marginal donors, living lobar and split lung donor techniques, and nonheartbeating donors have been used clinically to increase the number of donor lungs available.Chronic rejection of the lung allograft is currently the major hurdle limiting longterm survival. To date, prevention of known risk factors and treatment strategies have not lessened the devastating toll this process has on lung transplant survival. Better understanding of the cause of chronic rejection is needed in order to develop novel strategies for its treatment. Promotion of immune tolerance is a promising area that could potentially eliminate chronic rejection.The present article discusses recent advances in lung transplantation. It also details the major issues facing the field today. Only through continued clinical and experimental investigation will lung transplantation eventually reach its full potential. Eur Respir J 2003; 22: Suppl. 47, 57s-64s.

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Controlled Reperfusion Protects Lung Grafts During a Transient Early Increase in Permeability

Cited by 51 publications

References 18 publications

Influence of right ventricular function on the development of primary graft dysfunction after lung transplantation

Influence of right ventricular function on the development of primary graft dysfunction after lung transplantation

Institutional experience with extracorporeal membrane oxygenation in lung transplantation☆

Current status of lung transplantation

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