Controlled release studies through chitosan-based hydrogel synthesized at different polymerization stages

Rasib, Siti Zalifah Md; Hazizan, Akil; Khan, Abbas; Hamid, Zuratul Ain Abdul

doi:10.1016/j.ijbiomac.2019.01.190

Cited by 25 publications

(9 citation statements)

References 30 publications

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“…As per literature, chitosan built hydrogel have been synthesized from several methods [14][15][16][17][18]. In this study, C1CS-co-SR nanohydrogels were prepared by free radical copolymerization method as reported earlier [19].…”

Section: Synthesis and Surface Modification/ Functionalization Of Chimentioning

confidence: 99%

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Synthesis and surface modification of chitosan built nanohydrogel with antiviral and antimicrobial agent for controlled drug delivery

2019

Biointerface Res Appl Chem

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As hydrophobic drug carriers, chitosan (CS) and Starch (SR) were copolymerized as biodegradable nanohydrogel and were functionalized with pthalic-anhydride and hexamethylenetetramine via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide catalyzed coupling, respectively. The structure, morphology, physicochemical and drug loading performance of native and functioned hydrogel were investigated by using several characterization techniques. With the successive functionalization the significant properties like porosity increases and crosslinking density decreases due to the formation of hydrophilic contacts with aqueous solutions. The FESEM analysis revealed the hydrogel matrices with uniform particle size, porosity and deep pores with high internal surface area for extreme swelling and interacting with the drug and biomolecules for efficient drug administration. The effect of induced functionalities on the physicochemical performance and release of hydrophobic- anionic model drug (Bromocresol green) were studied at physiological conditions. The drug release capability of the synthesized nanohydrogel was increased from 65% to 80% and 85% by successive functionalization. The drug administration in selective hydrogel was not significant, presumably due to stronger H-bonding and entanglement within the system which was finely tuned by the induced hydrophilic, flexible and biocompatible functionalities in term of extended interfaces for the drug solutions. The physicochemical and electrokinetic performances suggested the selective hydrogel as promising carriers for the hydrophobic- anionic drugs at physiological conditions.

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Section: Synthesis and Surface Modification/ Functionalization Of Chimentioning

confidence: 99%

“…Thus the concentration of the released drug was investigated in term of Absorbance followed by concentration differences. The in vitro release tests of all samples were conducted in triplicate at specified time intervals [28].…”

Section: Photoluminescence Analysis Of Drug Loading and Releasementioning

confidence: 99%

Synthesis and surface modification of chitosan built nanohydrogel with antiviral and antimicrobial agent for controlled drug delivery

2019

Biointerface Res Appl Chem

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“…Polysaccharides such as chitosan, alginate, carrageenan, and cellulose are the most commonly used in pharmaceutical formulations. However, they suffer from several drawbacks, such as poor elasticity [ 2 ] and low water retention [ 3 ]. Sacran is a polysaccharide polymer that has a high water retention, high potential to develop, and a better elasticity than other polymers.…”

Section: Introductionmentioning

confidence: 99%

The Use of Megamolecular Polysaccharide Sacran in Food and Biomedical Applications

et al. 2021

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Natural polymer is a frequently used polymer in various food applications and pharmaceutical formulations due to its benefits and its biocompatibility compared to synthetic polymers. One of the natural polymer groups (i.e., polysaccharide) does not only function as an additive in pharmaceutical preparations, but also as an active ingredient with pharmacological effects. In addition, several natural polymers offer potential distinct applications in gene delivery and genetic engineering. However, some of these polymers have drawbacks, such as their lack of water retention and elasticity. Sacran, one of the high-molecular-weight natural polysaccharides (megamolecular polysaccharides) derived from Aphanothece sacrum (A. sacrum), has good water retention and elasticity. Historically, sacran has been used as a dietary food. Moreover, sacran can be applied in biomedical fields as an active material, excipient, and genetic engineering material. This article discusses the characteristics, extraction, isolation procedures, and the use of sacran in food and biomedical applications.

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“…Copolymers of chitosan/Nipam or Nipmam combine the properties of both polymers. They are capable to swell and retain water and strongly interact with hydrophobic drug 41 such as sorafenib.…”

Section: Introductionmentioning

confidence: 99%

Stimuli‐responsive hybrid microgels for controlled drug delivery: Sorafenib as a model drug

Caputo

Aliberti

Cusano³

et al. 2020

J of Applied Polymer Sci

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Microgels (MGs) are synthetic colloidal hydrogel particles made of three dimensional polymer networks. Their chemical composition is crucial for their use as intelligent drug release systems operated by temperature control. Herein, several MGs using N-isopropylacrylamide (Nipam)/Nisopropylmethacrylamide (Nipmam), chitosan and acrylic/methacrylic acid have been synthesized by free radical polymerization reactions (NC MGs) and the effects of surfactants and different reaction times on size and swelling properties have been investigated. MGs have been identified and characterized by dynamic light scattering and atomic force microscopy, and finally used to optimize the encapsulation protocol of the hydrophobic drug sorafenib. The drug delivery system here described has encapsulation efficiency of 40% and releases 10% of the entrapped drug over about 16 h after the temperature is raised above the volume phase transition temperature. Data suggest that MGs with optimized composition may act as properly instructed entities able to trap and release biomolecules following external stimuli.

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Controlled release studies through chitosan-based hydrogel synthesized at different polymerization stages

Cited by 25 publications

References 30 publications

Synthesis and surface modification of chitosan built nanohydrogel with antiviral and antimicrobial agent for controlled drug delivery

Synthesis and surface modification of chitosan built nanohydrogel with antiviral and antimicrobial agent for controlled drug delivery

The Use of Megamolecular Polysaccharide Sacran in Food and Biomedical Applications

Stimuli‐responsive hybrid microgels for controlled drug delivery: Sorafenib as a model drug

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