Controlled release of vitamin D 3 using a nanocellulose-based membrane

Abstract

Background Epidemiological studies show that a significant fraction of the global population presents low levels of vitamin D3. In order to address this problem, one way to administer the vitamin is to incorporate it in novel drug delivery systems, such as transdermal devices. A possible substance for this purpose is cellulose, which has a long history of use in the health area. However, the application of nanostructured cellulose membranes, as local drug delivery systems, remains a challenge. Objective To develop a crystalline nanocellulose membrane as a new tool for the release of vitamin D3. Methods A new nanostructured membrane containing nanocellulose extracted from cotton linter and vitamin D3 was produced using the “casting” technique. The membrane was characterized using high-resolution scanning electron microscopy (FEG-SEM) and Fourier transform infrared spectroscopy (FT-IR). The kinetics of vitamin release was quantified using molecular spectroscopy (UV-Vis). Results The FT-IR spectra showed the presence of all the active components in the membrane sample, without structural alterations or the formation of new bonds. The FEG-SEM images showed the presence of vitamin crystals on the surface and in the interior of the membrane. The release of vitamin D3 occurred in a sustained manner, obtaining 3,029 IU mL-1 of vitamin D3 in 60 min. Conclusions The findings demonstrated that the membrane could be used for the sustained release of vitamin D3. This new biomaterial has potential as a new model for vitamin supplementation in individuals with vitamin D3 deficiency.