Controlled release of terbinafine hydrochloride from pH sensitive poly(acrylamide/maleic acid) hydrogels

Şen, Murat; Uzun, Cengiz; Güven, Olgun

doi:10.1016/s0378-5173(00)00449-x

Cited by 84 publications

(17 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[23][24][25] We chose acrylic acid (AAc) as the weakly acidic segment in acrylamide (AAm)-based hydrogel to prepare a random copolymer network, poly(AAc-co-AAm). The presence of AAc (pK a,AAc = 4.25) lends the hydrogel its pH responsiveness, as the swelling volume correlates with the degree of ionization of the hydrogel network.…”

mentioning

confidence: 99%

Bio‐inspired Design of Submerged Hydrogel‐Actuated Polymer Microstructures Operating in Response to pH

2011

View full text Add to dashboard Cite

Responsive and reversibly actuating surfaces have attracted significant attention recently due to their promising applications as dynamic materials [1] that may enable microfluidic mixing, [2] particle propulsion and fluid transport, [3] capture and release systems, [4] and antifouling. [5] Analogs in nature serve as inspiration for the design of such advanced adaptive materials systems⎯microorganisms use flagella for propulsion, [6] cilia line the human respiratory tract to sweep mucus from the lungs and prevent bacterial accumulation, [7] and echinoderms use pedicellariae for body cleaning and food capture. [8] Significant characteristics of these biological systems include functionality in a fluidic environment, controllable actuation direction or pattern, and the ability to translate chemical signals or stimulus into mechanical motion. Researchers have taken various approaches to fabricating biomimetic actuators, among which are biomorph actuators made using Micro Electromechanical Systems (MEMS) technology, [9] magnetically actuated poly(dimethylsiloxane) (PDMS) structures, [10] and artificial cilia or actuators made from responsive gel. [11,12] However, most fabricated actuators, such as MEMS or magneticallyactuated PDMS posts, must be driven by an external force or field and are not responsive to chemical stimuli. Actuating structures that have been made from responsive hydrogel are Submitted to 2 either low aspect ratio and their motion is not patternable, [11] or the movement is irreversible. [12] Microscale actuation systems which exhibit reversible chemo-mechanical response and control of actuation direction or pattern have proven difficult to achieve.Inspired by biological actuators, which can be broadly interpreted as composites consisting of an active "muscle" component coupled with a passive "bone" structure, we recently developed a hybrid actuation system in which a crosslinked acrylamide-based hydrogel, acting as an analog to muscle, drives the movement of embedded silicon [13,14] or polymer [15] microposts, serving as analogs to skeletal elements. Actuation was achieved by the swelling and contraction of the humidity-responsive gel upon hydration/drying. Actuation direction was controlled by modulating the hydrogel thickness; since thicker hydrogel exhibits a greater absolute change in volume than thin hydrogel, the forces exerted on the structures⎯and thus their actuation direction⎯can be patterned.However, a humidity responsive system will not function in the fluidic environment required for many applications such as propulsion, cargo transport, or microfluidics, and it is difficult to pattern uni-directional actuation of posts over large areas due to their lack of preferred bending direction. To enable the actuators to function in various environments, it is possible to alter the chemistry of the hydrogel muscle to make it shrink or swell while submerged in response to a range of stimuli including light, [16] temperature, [17] biomolecules (e.g. glucose), [18] or pH. [19] To gain additional ...

show abstract

mentioning

confidence: 99%

Bio‐inspired Design of Submerged Hydrogel‐Actuated Polymer Microstructures Operating in Response to pH

2011

View full text Add to dashboard Cite

show abstract

“…65 The design of a pH-sensitive layer that can release the acid in a controlled dose is another strategy that could be used to reduce the toxicity during the degradation of hierarchical CaP-based composites. 66 …”

Section: Resultsmentioning

confidence: 99%

Assembly of Layered Monetite-Chitosan Nanocomposite and Its Transition to Organized Hydroxyapatite

Ruan

Liberman

Zhang

et al. 2016

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Bioinspired synthesis of hierarchically structured calcium phosphate (CaP) material is a highly promising strategy for developing improved bone substitute materials. However, synthesis of CaP materials with outstanding mechanical properties still remains an ongoing challenge. Inspired by the formation of lamellar structure in nacre, we designed an organic matrix composed of chitosan and cis-butenediolic acid (maleic acid, MAc) that could assemble into a layered complex and further guide the mineralization of monetite crystals, resulting in the formation of organized and parallel arrays of monetite platelets with a brick-and-mortar structure. Using the layered monetite-chitosan composite as a precursor, we were able to synthesize hydroxyapatite (HAp) with multiscale hierarchically ordered structure via a topotactic phase transformation process. On the nanoscale, needlelike HAp crystallites assembled into organized bundles that aligned to form highly oriented plates on the microscale. On the large-scale level, these plates with different crystal orientations were stacked together to form a layered structure. The organized structures and composite feature yielded CaP materials with improved mechanical properties close to those of bone. Our study introduces a biomimetic approach that may be practical for the design of advanced, mechanically robust materials for biomedical applications.

show abstract

“…Intelligent or smart hydrogels have been developed as stimuliresponsive materials, which can undergo volume changes in response to changes in temperature, pH and antigen concentration. These unique characteristics are of great interest in drug release, cell encapsulation and tissue engineering [5][6][7][8][9]. Poly(N-isopropylacrylamide) (P(NIPAAm)) is a well-known thermo-responsive polymer which exhibits a lower critical solution temperature (LCST) of around 32ºC in an aqueous medium.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of vitamin B12 in aqueous solutions by poly(N-isopropylacrylamide/itaconic acid) copolymeric hydrogels

Taşdelen¹,

Güven²

2014

HJBC

Self Cite

View full text Add to dashboard Cite

Ö Z E T F arklı miktarda itakonik asit içereb N-izopropilakrilamid/itakonik asit kopolimerik hidrojelleri (NIPAAm/IA) g-radyasyonu ile sentezlendi. Sentezlenen hidrojeller Vitamin B 12 tutulumu ve salımını incelemekte kullanıldı. Vitamin B 12 adsorpsiyon deneylerinde S tipi adsorpsiyon izotermi bulundu. Hidrojellerin ilaç tutulumu ve salımı davranışları üzerinde komonomer konsantrasyonu ve ışınlama dozunun etkileri araştırıldı. Anahtar KelimelerHidrojel, N-izopropilakrilamid,itakonik asit, Vitamin B 12 A B S T R A C TN -isopropylacrylamide/itaconic acid copolymeric hydrogels (NIPAAm/IA) containing different quantities of itaconic acid have been irradiated with g radiation. The hydrogels were used in an experiment concerning the uptake and release behavior of Vitamin B 12 . In the experiment of the adsorption of Vitamin B 12 , type S adsorption isotherm was found. The effect of comonomer concentration and irradiation dose on the uptake and release behavior of the hydrogels was studied.

show abstract

Controlled release of terbinafine hydrochloride from pH sensitive poly(acrylamide/maleic acid) hydrogels

Cited by 84 publications

References 19 publications

Bio‐inspired Design of Submerged Hydrogel‐Actuated Polymer Microstructures Operating in Response to pH

Bio‐inspired Design of Submerged Hydrogel‐Actuated Polymer Microstructures Operating in Response to pH

Assembly of Layered Monetite-Chitosan Nanocomposite and Its Transition to Organized Hydroxyapatite

Adsorption of vitamin B12 in aqueous solutions by poly(N-isopropylacrylamide/itaconic acid) copolymeric hydrogels

Contact Info

Product

Resources

About