Controlled release of resveratrol from lipid nanoparticles improves antioxidant effect

Soldati, P.; Polonini, Hudson; Paes, Camila Quinetti; Restrepob, Jelver A.S.; Creczynksi-Pasa, Tânia B.; Chaves, Maria G.A.M.; Brandão, Marcos Antônio Fernandes; Pittella, Frederico; Raposo, Nádia Rezende Barbosa

doi:10.1016/j.ifacol.2018.11.600

Cited by 28 publications

(14 citation statements)

References 21 publications

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“…Nevertheless, NLC formulation had a great outcome concerning topical delivery of resveratrol. In accordance with these results, Soldati and collaborators (2018) found that the release profile of resveratrol from the NLC was biphasic, with a burst release within the first 4 h followed by a prolonged release over 24 h. Additionally, NLC improved the permeation and retention of the resveratrol in the upper layers of skin and enhanced by 20% the antioxidant activity of resveratrol, compared to the free active [ 113 ].…”

Section: Nlc Containing Natural Substances Against Skin Inflammationmentioning

confidence: 70%

“…Among the advantages of NLC, the lipids used in the composition of these systems (i) are usually non-irritating and non-toxic, (ii) allow the encapsulation of lipophilic compounds, (iii) increase drug stability, (iv) protect the active against degradation, (v) improve the drug load, (vi) possess eco-friendly production methods, and (vii) present ease of sterilization [ 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 ]. Together, these characteristics make NLC excellent vehicles for actives used in the treatment of inflammatory skin diseases.…”

Section: Nanostructured Lipid Carriers (Nlc)mentioning

confidence: 99%

“…The natural polyphenolic compound resveratrol has a potent antioxidant with strong anti-inflammatory properties. Two studies analyzed resveratrol incorporated into NLC [ 113 ]. Sun and colleagues compared nanoemulsion, SLN, and NLC formulations encapsulating resveratrol for topical delivery [ 148 ].…”

Section: Nlc Containing Natural Substances Against Skin Inflammationmentioning

confidence: 99%

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Nanostructured Lipid Carriers for the Formulation of Topical Anti-Inflammatory Nanomedicines Based on Natural Substances

et al. 2021

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The main function of the skin is to protect the body from the external environment. However, the skin can undergo inflammatory processes, due to genetic, hormonal, or environmental factors. When the defense system is overloaded, there is an increase in pro-inflammatory mediators and reactive oxygen species (ROS), which results in skin disorders. Among the substances used to treat these inflammatory processes, many natural substances with anti-inflammatory and antioxidant properties are being studied: nature is yet an abundant source to obtain diverse pharmacological actives. The treatment of skin diseases is usually focused on topical application, as it reduces the risk of systemic side effects and prevents drug degradation by first-pass metabolism. Thus, the properties of drug delivery vehicles can facilitate or inhibit its permeation. Due to the hydrophobic nature of the skin, a promising strategy to improve dermal drug penetration is the use of lipid-based nanoparticles, such as nanostructured lipid carriers (NLC). Therefore, in this review, we present NLC as a tool to improve dermal administration of natural substances with anti-inflammatory properties.

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Section: Nlc Containing Natural Substances Against Skin Inflammationmentioning

confidence: 70%

Section: Nanostructured Lipid Carriers (Nlc)mentioning

confidence: 99%

Section: Nlc Containing Natural Substances Against Skin Inflammationmentioning

confidence: 99%

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Nanostructured Lipid Carriers for the Formulation of Topical Anti-Inflammatory Nanomedicines Based on Natural Substances

et al. 2021

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“…Resveratrol has been also loaded in SLNs in a study against insulin resistance through improving the hypoglycemic effect and up-regulating the expression of diabetes-related proteins. The formulation was administered to rats and the results revealed promising hypoglycemic properties [ 144 ]. SLNs loaded with (+)-limonene 1,2-epoxide have also been produced using glycerol monostearate by means of hot high-pressure homogenization [ 145 ].…”

Section: Organic-based Delivery Systemsmentioning

confidence: 99%

Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications

Kyriakoudi

Spanidi²,

Mourtzinos

et al. 2021

Plants

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Plants constitute a rich source of diverse classes of valuable phytochemicals (e.g., phenolic acids, flavonoids, carotenoids, alkaloids) with proven biological activity (e.g., antioxidant, anti-inflammatory, antimicrobial, etc.). However, factors such as low stability, poor solubility and bioavailability limit their food, cosmetics and pharmaceutical applications. In this regard, a wide range of delivery systems have been developed to increase the stability of plant-derived bioactive compounds upon processing, storage or under gastrointestinal digestion conditions, to enhance their solubility, to mask undesirable flavors as well as to efficiently deliver them to the target tissues where they can exert their biological activity and promote human health. In the present review, the latest advances regarding the design of innovative delivery systems for pure plant bioactive compounds, extracts or essential oils, in order to overcome the above-mentioned challenges, are presented. Moreover, a broad spectrum of applications along with future trends are critically discussed.

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“…O valor de EE encontrado nas OM-NLS foi de 92,74% ± 0,012%, o que pode ser explicado pela composição variada da manteiga de cupuaçu, que devido às imperfeições na estrutura lipídica, permite uma maior incorporação de ativos no interior do nanocarreador. De fato, alguns autores (ANDONOVA e PENEVA, 2017; BATTAGLIA e GALLARATE, 2012;SOLDATI et al, 2018) relataram que a incorporação de óleos essenciais na matriz lipídica sólida faz com que aumente o número de imperfeições na mesma, facilitando a incorporação de uma quantidade maior de fármaco, enquanto mantém a estabilidade física da nanopartícula. Outra inferência que poderia justificar o valor elevado de EE, é solubilidade satisfatória do OM nos lipídios da manteiga de cupuaçu.…”

Section: Determinação Da Eficiência De Encapsulação Das Om-nlsunclassified

Nanopartículas lipídicas sólidas contendo óleo essencial de Melaleuca alternifolia Cheel como plataforma inovadora no tratamento da candidíase orofaríngea

Gonçalves¹

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Espécies do gênero Candida spp. são frequentemente encontradas na microbiota bucal vivendo de forma comensal; mas podem mudar para o estado patogênico e gerar candidíase orofaríngea, que pode evoluir para candidemia. Apesar da importância clínica e epidemiológica dessas infecções, as opções terapêuticas são limitadas, o que tem estimulado a busca por novos medicamentos, dentre eles os de origem vegetal e o emprego da nanotecnologia como estratégia tecnológica. Nesse contexto, o presente estudo teve como objetivo desenvolver uma plataforma inovadora para o tratamento da candidíase orofaríngea, constituída por um hidrogel contendo o óleo de Melaleuca alternifolia Cheel (OM) encapsulado em nanopartículas lipídicas sólidas (NLS). A composição química do óleo foi avaliada por cromatografia gasosa acoplada à espectrometria de massas. As NLS foram caracterizadas em relação ao tamanho hidrodinâmico médio das partículas (TP), índice de polidispersividade (PdI), potencial Zeta (PZ), eficiência de encapsulação (EE), morfologia, estabilidade, potencial antioxidante e citotoxicidade in vitro em linhagem celular de fibroblastos murinos (L929). As NLS contendo OM (OM-NLS) foram incorporadas em hidrogel e, em seguida, verificou-se a atividade antifúngica frente a leveduras padrão de C. albicans, C. glabrata, C. krusei e C. guilliermondii. Por fim, a permeação ex vivo do OM a partir do hidrogel, utilizando mucosa jugal suína foi analisada. Foram identificados treze constituintes no OM, cuja composição percentual atendeu aos padrões descritos pela ISO 4730: 2017. Quanto à caracterização das OM-NLS, os valores para TP, PdI e PZ foram 135,9 ± 6,65; 0,19 ± 0,04 e -31,07 ± 1,05, respectivamente. As OM-NLS mostraram uma EE de 92,74% ± 0,012% e revelaram uma forma esférica. Além disso, a atividade antioxidante variou de 14,1% a 17,2% e foi encontrado efeito citotóxico contra a linhagem celular L929 (IC50 = 77,4 µg/mL). Por pelo menos 120 dias, não foram observadas mudanças significativas nos valores da média de TP e PdI para OM-NLS, e o hidrogel contendo OM-NLS permaneceu estável por minimamente 30 dias, ambos sob refrigeração. OM-NLS e hidrogel contendo OM-NLS exibiram efeito fungicida (concentração fungicida mínima variou entre 5,60 e 11,20 mg/mL; e 5,53 e 11,06 mg/mL, respectivamente); e permeação transmucosa (70,52% ± 3,85%). Concluiu-se que o hidrogel contendo OM-NLS apresentou efeito fungicida superando o OM, estabilidade durante o período de avaliação e foi permeável pela mucosa jugal suína, podendo ser, portanto um sistema de entrega promissor na candidíase orofaríngea.

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Controlled release of resveratrol from lipid nanoparticles improves antioxidant effect

Cited by 28 publications

References 21 publications

Nanostructured Lipid Carriers for the Formulation of Topical Anti-Inflammatory Nanomedicines Based on Natural Substances

Nanostructured Lipid Carriers for the Formulation of Topical Anti-Inflammatory Nanomedicines Based on Natural Substances

Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications

Nanopartículas lipídicas sólidas contendo óleo essencial de Melaleuca alternifolia Cheel como plataforma inovadora no tratamento da candidíase orofaríngea

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